Regulatory T cell activity in primary and persistent epstein-barr virus infection

Journal of Medical Virology

Volumn 81, Issue 5, 2009, Pages 870-877

  Wingate, P J ^a   McAulay, K A ^a   Anthony, I C ^a   Crawford, D H ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Immune response; Infectious mononucleosis; Regulatory cytokines

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; LATENT MEMBRANE PROTEIN 1; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; INFECTION CONTROL; INFECTIOUS MONONUCLEOSIS; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; PERSISTENT INFECTION; PRIMARY INFECTION; REGULATORY T LYMPHOCYTE; TONSIL; VIRUS INFECTION;

ANTIBODIES, VIRAL; CHRONIC DISEASE; CYTOKINES; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; INFECTIOUS MONONUCLEOSIS; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; VIRAL MATRIX PROTEINS;

HUMAN HERPESVIRUS 4;

EID: 65649113204     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21445     Document Type: Article

References (19)

1. Aandahl EM, Michaelsson J, Moretto WJ, Hecht FM, Nixon DF. 2004. Human CD4 + CD25 + regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol 78:2454-2459.
2. Attarbaschi T, Willheim M, Ramharter M, Hofmann A, Wahl K, Winkler H, Graninger W, Winkler S. 2003. T cell cytokine profile during primary Epstein-Barr virus infection (infectious mononucleosis). Eur Cytokine Netw 14:34-39.
3. high regulatory cells in human peripheral blood. J Immunol 167:1245-1253.
4. Biglino A, Sinicco A, Forno B, Pollono AM, Sciandra M, Martini C, Pich P, Gioannini P. 1996. Serum cytokine profiles in acute primary HIV-1 infection and in infectious mononucleosis. Clin Immunol Immunopathol 78:61-69.
5. Boettler T, Spangenberg HC, Neumann-Haefelin C, Panther E, Urbani S, Ferrari C, Blum HE, von Weizsacker F, Thimme R. 2005. T cells with a CD4 + CD25 + regulatory phenotype suppress in vitro proliferation of virus-specific CD8 + T cells during chronic hepatitis virus infection. J Virol 79:7860-7867.
6. Callan M, Steven N, Krausa P. 1996. Large clonal expansion of CD8 + T cells in acute infectious mononucleosis. Nat Med 2:906-911.
7. Corsi MM, Ruscica M, Passoni D, Scarmozzino MG, Gulletta E. 2004. High TH1-type cytokine serum levels in patients with infectious mononucleosis. Acta Virol 48:263-266.
8. Crawford DH. 2001. Biology and disease associations of Epstein-Barr virus. Phil Trans Roy Soc B Biol Sci 356:461-473.
9. Foss H-D, Herbst H, Hummel M, Araujo I, Latza U, Rancso C, Dallenbach F, Stein H. 1994. Patterns of cytokine gene expression in infectious mononucleosis. Blood 83:707-712.
10. Marshall NA, Vickers MA, Barker RN. 2003. Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 1. J Immunol 170:6183-6189.
11. Marshall NA, Christie LE, Munro LR, Culligan DJ, Johnston PW, Barker RN, Vickers MA. 2004. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 103:1755-1762.
12. Marshall NA, Culligan DJ, Johnston PW, Millar C, Barker RN, Vickers MA. 2007. CD4 + T-cell responses to Epstein-Barr virus (EBV) latent membrane protein 1 in infectious mononucleosis and EBV-associated non-Hodgkin lymphoma: Th1 in active disease but Tr1 in remission. Brit J Haematol 139:81-89.
13. McAulay KA, Higgins CD, Macsween KF, Lake A, Jarrett RF, Robertson FL, Williams H, Crawford DH. 2007. HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection. J Clin Invest 117:3042-3048.
14. McGeoch DJ, Rixon FJ, Davison AJ. 2006. Topics in herpesvirus genomics and evolution. Virus Res 117:90-104.
15. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR. 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 248:1230-1234.
16. O'Garra A, Vieira P. 2004. Regulatory T cells and mechanisms of immune system control. Nat Med 10:801-805.
17. Rouse BT, Suvas S. 2004. Regulatory cells and infectious agents: Détentes cordiale and contraire. J Immunol 173:2211-2215.
18. Voo KS, Peng G, Guo Z, Fu T, Li Y, Frappier L, Wang R-F. 2005. Functional characterisation of EBV-encoded nuclear antigen 1-specific CD4 helper and regulatory Tcells elicited by in vitro peptide stimulation. Cancer Res 65:1577-1586.
19. Williams H, Macsween KF, McAulay K, Higgins C, Harrison N, Swerdlow A, Britton K, Crawford D. 2004. Analysis of immune activation and clinical events in acute infectious mononucleosis. J Infect Dis 190:63-71.