Selective blockade of mGlu5 metabotropic glutamate receptors is hepatoprotective against fulminant hepatic failure induced by lipopolysaccharide and D-galactosamine in mice

Journal of Applied Toxicology

Volumn 29, Issue 4, 2009, Pages 323-329

  Jesse, Cristiano R ^a   Wilhelm, Ethel A ^a   Bortolatto, Cristiani F ^a   Savegnago, Lucielli ^b   Nogueira, Cristina W ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b UNIVERSIDADE FEDERAL DO PAMPA   (Brazil)

Author keywords

D galactosamine; Hepatotoxicity; Lipopolysaccharide; Liver; mGlu5 receptor antagonist; Mice; MPEP; Oxidative stress

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; ALANINE AMINOTRANSFERASE; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; GALACTOSAMINE; GLUTATHIONE TRANSFERASE; LIPOPOLYSACCHARIDE; METABOTROPIC RECEPTOR 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOLOGY; LIPID PEROXIDATION; LIVER; LIVER FAILURE; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TOXICOLOGICAL PARAMETERS;

ALANINE TRANSAMINASE; ANIMALS; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASES; CATALASE; EXCITATORY AMINO ACID ANTAGONISTS; GALACTOSAMINE; GLUTATHIONE TRANSFERASE; HEPATITIS, TOXIC; INJECTIONS, INTRAPERITONEAL; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; LIVER FAILURE, ACUTE; MICE; PROTECTIVE AGENTS; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; SURVIVAL ANALYSIS;

MUS;

EID: 65649111752     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1413     Document Type: Article

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