Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage

European Journal of Pharmacology

Volumn 497, Issue 1, 2004, Pages 25-27

  Storto, Marianna ^a   Battaglia, Giuseppe ^a   Gradini, Roberto ^a,b   Bruno, Valeria ^a,b   Nicoletti, Ferdinando ^a,b   Vairetti, Mariapia ^c  

^a IRCCS NEUROMED   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

Hypoxia; mGlu5 knockout; mouse; Reactive oxygen species

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; LACTATE DEHYDROGENASE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL HYPOXIA; CELL ISOLATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME RELEASE; HYPOTHESIS; KNOCKOUT MOUSE; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; WILD TYPE;

ANIMALS; CELL HYPOXIA; CELL SURVIVAL; HEPATOCYTES; L-LACTATE DEHYDROGENASE; MICE; MICE, KNOCKOUT; REACTIVE OXYGEN SPECIES; RECEPTORS, METABOTROPIC GLUTAMATE; TIME FACTORS;

EID: 4143056101     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.06.023     Document Type: Article

References (8)

1. H.U. Bergmeyer Methods of Enzymatic Analysis 1965 New York Academic Press 736 743
2. Y.M. Lu, Z. Jia, C. Janus, J.T. Hendersen, R. Gerlai, J.M. Wojtowicz, and J.C. Roder Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP J. Neurosci. 17 1997 5196 5205
3. P. Moldeus, J. Hogberg, and S. Orrenius Isolation and use of liver cells Methods Enzymol. 51 1978 60 70
4. S. Nakanishi Molecular diversity of glutamate receptors and implications for brain function Science 258 1992 597 602
5. D.D. Schoepp, D.E. Jane, and A.J. Monn Pharmacological agents acting at subtypes of metabotropic glutamate receptors Neuropharmacology 38 1999 1431 1476
6. M. Storto, U. de Grazia, T. Knöpfel, P.L. Canonico, A. Copani, P. Richelmi, F. Nicoletti, and M. Vairetti Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage Hepatology 31 2000 649 655
7. M. Storto, G. Battaglia, R.T. Ngomba, I. Freitas, P. Griffini, P. Richelmi, F. Nicoletti, and M. Vairetti Selective blockade of mGlu5 metabotropic glutamate receptors is highly protective against acetaminophen hepatotoxicity in mice J. Hepatol. 38 2003 179 187
8. F. Sureda, A. Copani, V. Bruno, T. Knopfel, G. Meltzger, and F. Nicoletti Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes Eur. J. Pharmacol. 338 1997 R1 R2