Irradiated cultured apoptotic peripheral blood mononuclear cells regenerate infarcted myocardium

European Journal of Clinical Investigation

Volumn 39, Issue 6, 2009, Pages 445-456

  Ankersmit, H J ^a,b   Hoetzenecker, K ^b   Dietl, W ^d   Soleiman, A ^b   Horvat, R ^b   Wolfsberger, M ^b   Gerner, C ^b   Hacker, S ^b   Mildner, M ^c   Moser, B ^b   Lichtenauer, M ^b   Podesser, B K ^d  

^a Department of Cardiac and Thoracic Surgery ^*  (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Universitatsklinik fur Dermatologie   (Austria)

^d Ludwig Boltzmann Cluster for Cardiovascular Research   (Austria)

Author keywords

Acute myocardial infarction; C kit; Endothelial progenitor cells; Immunosuppression; PBMC

Indexed keywords

GELATINASE B; INTERLEUKIN 8; MESSENGER RNA; VASCULOTROPIN;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL HOMING; CELL REGENERATION; CONTROLLED STUDY; FIBROBLAST; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; IMMUNOREACTIVITY; IN VITRO STUDY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; MYOCARDIAL INFARCTION; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 65549156624     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2009.02111.x     Document Type: Article

References (48)

1. Cohn JN, Bristow MR, Chien KR, Colucci WS, Frazier OH, Leinwand LA et al. Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel of Heart Failure Research. Circulation 1997 95 : 766 70. (Pubitemid 27091506)
2. Nian M, Lee P, Neelam K, Liu P. Inflammatory cytokines and postmyocardial infarction remodeling. Circ Res 2004 94 : 1543 53. (Pubitemid 38856961)
3. Anversa P, Nadal-Ginard B. Myocyte renewal and ventricular remodelling. Nature 2002 415 : 240 3. (Pubitemid 34059531)
4. Saraste A, Pulkki K, Kallojoki M, Henrikson K, Parvinen M, Voipio-Pulkki LM. Apoptosis in human acute myocardial infarction. Circulation 1997 95 : 320 3. (Pubitemid 27056193)
5. Sun M, Opavsky A, Steward DJ, Babinovitich M, Dawood F, Wen WH et al. Temporal response and localization of integrins beta-1 and beta-2 in the heart following myocardial infarction: regulation by cytokines. Circulation 2003 107 : 1046 52. (Pubitemid 36258730)
6. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995 1 : 27 31.
7. Zhang J, Yu ZX, Fujita S, Yamaguchi ML, Ferrans VJ. Interstitial dendritic cells of the rat heart. Quantitative and ultrastructural changes in experimental myocardial infarction. Circulation 1993 87 : 909 20. (Pubitemid 23070823)
8. Kloner RA, Fishbein MC, Lew H, Maroko PR, Braunwald E. Mummification of the infarcted myocardium by high dose corticosteroids. Circulation 1978 57 : 56 63. (Pubitemid 8254675)
9. Ferrari G, Cusella-De Angelis G, Coletta M, Paolucci E, Stornaiuolo A, Cossu G et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998 279 : 1528 30. (Pubitemid 28217075)
10. Jackson KA, Mi T, Goodell MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci USA 1999 96 : 14482 6. (Pubitemid 30000676)
11. Eglitis MA, Mezey E. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc Natl Acad Sci U S A 1997 94 : 4080 5. (Pubitemid 27180502)
12. Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L et al. Liver from bone marrow in humans. Hepatology 2000 32 : 11 6. (Pubitemid 30432360)
13. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001 410 : 701 5. (Pubitemid 32290358)
14. von Harsdorf R, Poole-Wilson PA, Dietz R. Regenerative capacity of the myocardium: implications for treatment of heart failure. Lancet 2004 363 : 1306 13. (Pubitemid 38496496)
15. Ren Y, Silverstein RL, Allen J, Savill J. CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. J Exp Med 1995 181 : 1857 62.
16. Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest 1998 101 : 890 8. (Pubitemid 28096086)
17. Bittencourt MC, Perruche S, Contassot E, Fresnay S, Baron MH, Angonin R et al. Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers. Blood 2001 98 : 224 30.
18. Perruche S, Kleinclauss F, Bittencourt Mde C, Paris D, Tiberghien P, Saas P. Intravenous infusion of apoptotic cells simultaneously with allogenic hematopoietic grafts alters anti-donor humoral immune responses. Am J Transplant 2004 4 : 1361 5. (Pubitemid 39013586)
19. Sun E, Gao Y, Chen J, Roberts AI, Wang X, Chen Z et al. Allograft tolerance induced by donor apoptotic lymphocytes requires phagocytosis in the recipient. Cell Death Differ 2004 11 : 1258 64. (Pubitemid 39591771)
20. Wang Z, Larregina AT, Shufesky WJ, Perone MJ, Montecalvo A, Zahorchak AF et al. Use of the inhibitory effect of apoptotic cells on dendritic cells for graft survival via T-cell deletion and regulatory T cells. Am J Transplant 2006 6 : 1297 311. (Pubitemid 44030313)
21. Kurosaka K, Watanabe N, Kobayashi Y. Potentiation by human serum of anti-inflammatory cytokine production by human macrophages in response to apoptotic cells. J Leukoc Biol 2002 71 : 950 6.
22. Golpon HA, Fadok VA, Taraseviciene-Stewart L, Scerbavicius R, Sauer C, Welte T et al. Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J 2004 18 : 1716 8. (Pubitemid 39561661)
23. Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett N et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 2002 109 : 625 37. (Pubitemid 34628725)
24. Boerma M, Schutte-Bart CI, Wedekind LE, Beekhuizen H, Wondergem J. Effects of multiple doses of ionizing radiation on cytokine expression in rat and human cells. Int J Radiat Biol 2003 79 (11 889 96. (Pubitemid 38067856)
25. Kadl A, Huber J, Gruber F, Bochkov VN, Binder BR, Leitinger N. Analysis of inflammatory gene induction by oxidized phospholipids in vivo by quantitative real-time RT-PCR in comparison with effects of LPS. Vascul Pharmacol 2002 38 : 219 27. (Pubitemid 36398267)
26. Wellmann S, Taube T, Paal K, Einsiedel H, Geilen W, Seifert G et al. Specific reverse transcription-PCR quantification of vascular endothelial growth factor (VEGF) splice variants by LightCycler Technology. Clin Chem 2001 47 : 654 60. (Pubitemid 32275807)
27. Trescher K, Bernecker O, Fellner B, Gyöngyösi M, Schäfer R, Aharinejad S et al. Inflammation and postinfarct remodeling: overexpression of IkappaB prevents ventricular dilation via increasing TIMP levels. Cardiovasc Res 2006 69 : 746 54. (Pubitemid 43139737)
28. Petersen MS, Petersen CC, Agger R, Hokland M, Gundersen HJ. A simple method for unbiased quantitation of adoptively transferred cells in solid tissue. J Immunol Methods 2006 309 : 173 81. (Pubitemid 43190813)
29. Kerjaschki D, Regele HM, Moosberger I, Nagy-Bojarski K, Watschinger B, Soleiman A et al. Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. J Am Soc Nephrol 2004 15 : 603 12. (Pubitemid 38294790)
30. Strieter RM, Kunkel SL, Elner VM, Martonyi CL, Koch AE, Polverini PJ et al. Interleukin-8: a corneal factor that induces neovascularization. Am J Pathol 1992 141 : 1279 84. (Pubitemid 23002612)
31. Murdoch C, Monk PN, Finn A. Cxc chemokine receptor expression on human endothelial cells. Cytokine 1999 11 : 704 12. (Pubitemid 29428004)
32. Koch AE, Plverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM et al. Interleukin-8 (IL-8) as a macrophage-derived mediator of angiogenesis. Science 1992 258 : 1798 801. (Pubitemid 23087348)
33. Strieter RM, Polverini PJ, Kunkel SL, Arenberg DA, Burdick MD, Kasper J et al. The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem 1995 270 : 27348 57.
34. Kennedy M, Firpo M, Choi K, Wall C, Robertson S, Kabrun N et al. A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature 1997 386 : 488 93. (Pubitemid 27164073)
35. Pruijt J, Willemze R, Fibbe W. Mechanisms underlying haematopoietic stem cell mobilization induced by the CXC chemokine interleukin-8. Curr Opin Hematol 1999 6 : 152 8. (Pubitemid 29467538)
36. Schömig K, Busch G, Steppich B, Sepp D, Kaufmann J, Stein A et al. Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarction. Eur Heart J 2006 27 : 1032 7.
37. Fazel SS, Chen L, Angoulvant D, Li SH, Weisel RD, Keating A et al. Activation of c-kit is necessary for mobilization of the reparative bone marrow progenitor cells in response to cardiac injury. FASEB J 2008 22 : 930 40.
38. Kurpisz M, Czepczyński R, Grygielska B, Majewski M, Fiszer D, Jerzykowska O et al. Bone marrow stem cell imaging after intracoronary administration. Int J Cardiol 2007 121 : 194 5. (Pubitemid 47381321)
39. Aicher A, Brenner W, Zuhayra M, Badorff C, Massoudi S, Assmus B et al. Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 2003 107 : 2134 9. (Pubitemid 36532196)
40. Hwang MW, Matsumori A, Furukawa Y, Ono K, Okada M, Iwasaki A et al. Neutralization of interleukin-1beta in the acute phase of myocardial infarction promotes progression in left ventricular remodeling. J Am Coll Cardiol 2001 38 : 1546 53. (Pubitemid 33034617)
41. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 2001 98 : 10344 9. (Pubitemid 32803022)
42. Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P et al. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 2006 116 : 1865 77. (Pubitemid 44033311)
43. Ayach BB, Yoshimitsu M, Dawood F, Sun M, Arab S, Chen M et al. Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction. Proc Natl Acad Sci USA 2006 103 : 2304 9. (Pubitemid 43271665)
44. Massa M, Rosti V, Ferrario M, Campanelli R, Ramajoli I, Rosso R et al. Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood 2005 105 : 199 206. (Pubitemid 40053083)
45. Leri A, Kajstura J, Anversa P. Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev 2005 85 : 1373 416. (Pubitemid 41362274)
46. Tillmanns J, Rota M, Hosoda T, Misao Y, Esposito G, Gonzalez A et al. Formation of large coronary arteries by cardiac progenitor cells. Proc Natl Acad Sci U S A 2008 105 : 1668 73.
47. Bearzi C, Rota M, Hosoda T, Tillmanns J, Nascimbene A, De Angelis A et al. Human cardiac stem cells. Proc Natl Acad Sci USA 2007 104 : 14068 73. (Pubitemid 350003336)
48. Fransioli J, Bailey B, Gude NA, Cottage CT, Muraski JA, Emmanuel G et al. Evolution of the c-kit positive cell response to pathological challenge in the myocardium. Stem Cells 2008 26 : 1315 24.