Expression of proteinase-activated receptor-2 in the intervertebral disc

Spine

Volumn 34, Issue 5, 2009, Pages 470-478

  Iida, Ryu ^a   Akeda, Koji ^a   Kasai, Yuichi ^a   Masuda, Koichi ^b   Morimoto, Ryo ^a   Sakakibara, Toshihiko ^c   Sato, Masayoshi ^c   Uchida, Atsumasa ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b University of California ^*  (United States)

^c Department of Orthopaedic Surgery   (Japan)

Author keywords

Disc degeneration; Human; Intervertebral disc; Matrix metalloproteinase; Proteinase activated receptor 2; Rat; Serine proteinase

Indexed keywords

COLLAGENASE 3; DISINTEGRIN; INTERLEUKIN 1BETA; METALLOPROTEINASE; PROTEINASE ACTIVATED RECEPTOR 2; STROMELYSIN; THROMBOSPONDIN; 2 FUROYL LIGRLO AMIDE; 2-FUROYL-LIGRLO-AMIDE; ADAM PROTEIN; AGGRECANASE 1; AGGRECANASE-1; MESSENGER RNA; OLIGOPEPTIDE; PROCOLLAGEN N PROTEINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTERVERTEBRAL DISK; MALE; NONHUMAN; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ADULT; AGED; ANIMAL; CELL CULTURE; CELL DIVISION; CYTOLOGY; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; INTERVERTEBRAL DISK HERNIA; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ADAM PROTEINS; ADULT; AGED; ANIMALS; CELL DIVISION; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; MALE; METABOLISM; MIDDLE AGED; OLIGOPEPTIDES; PROCOLLAGEN N-ENDOPEPTIDASE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PAR-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 65549155318     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318195a67d     Document Type: Article

References (42)

1. Urban JP, Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther 2003;5:120-30.
2. Battie MC, Videman T, Parent E. Lumbar disc degeneration: epidemiology and genetic influences. Spine2004;29:2679-90.
3. Adams P, Muir H. Qualitative changes with age of proteoglycans of human lumbar discs. Ann Rheum Dis 1976;35:289-96.
4. Cole TC, Ghosh P, Taylor TK. Variations of the proteoglycans of the canine intervertebral disc with ageing. Biochim Biophys Acta 1986;880:209-19.
5. Lyons G, Eisenstein SM, Sweet MB. Biochemical changes in intervertebral disc degeneration. Biochim Biophys Acta 1981;673:443-53.
6. Oegema TR Jr. Biochemistry of the intervertebral disc. Clin Sports Med 1993;12:419-39.
7. Hoyland JA, Maitre CL, Freemont AJ. Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology (Oxford) 2008.
8. Le Maitre CL, Freemont AJ, Hoyland JA. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005;7:R732-45.
9. Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFal-pha expression profile. Arthritis Res Ther 2007;9:R77.
10. Miyamoto K, Pichika R, An H, et al. Tumor necrosis factor-α exhibits potent effects on the metabolism of human intervertebral disc cells. Trans Orthop Res Soc 2005:188.
11. Le Maitre CL, Freemont AJ, Hoyland JA. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 2004;204:47-54.
12. Roberts S, Caterson B, Menage J, et al. Matrix metalloproteinases and ag-grecanase: their role in disorders of the human intervertebral disc. Spine2000;25:3005-13.
13. Weiler C, Nerlich AG, Zipperer J, et al. 2002 SSE Award Competition in Basic Science: expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur Spine J 2002;11: 308-20.
14. Patel KP, Sandy JD, Akeda K, et al. Aggrecanases and aggrecanase- generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration. Spine2007;32:2596-603.
15. Cole TC, Melrose J, Ghosh P. Isolation and characterisation of a neutral proteinase from the canine intervertebral disc. Biochim Biophys Acta 1989; 990:254-62.
16. Fujita K, Nakagawa T, Hirabayashi K, et al. Neutral proteinases in human intervertebral disc. Role in degeneration and probable origin. Spine1993; 18:1766-73.
17. Ossovskaya VS, Bunnett NW. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 2004;84:579-621.
18. Steinhoff M, BuddenkotteJ, Shpacovitch V, et al. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 2005;26:1-43.
19. Boileau C, Amiable N, Martel-Pelletier J, et al. Activation of proteinase-activated receptor 2 in human osteoarthritic cartilage upregulates catabolic and proinflammatory pathways capable of inducing cartilage degradation: a basic science study. Arthritis Res Ther 2007;9:R121.
20. Freund-Michel V, Frossard N. Inflammatory conditions increase expression of protease-activated receptor-2 by human airway smooth muscle cells in culture. Fundam Clin Pharmacol 2006;20:351-7.
21. Nystedt S, Ramakrishnan V, Sundelin J. The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. Comparison with the thrombin receptor. J Biol Chem 1996;271:14910-5.
22. Ritchie E, Saka M, Mackenzie C, et al. Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory κ-B kinase β in human endothelial cells. Br J Pharmacol 2007; 150:1044-54.
23. Xiang Y, Masuko-Hongo K, Sekine T, et al. Expression of proteinase-activated receptors (PAR)-2 in articular chondrocytes is modulated by IL-1β, TNF-α and TGF-β. Osteoarthr Cartil 2006;14:1163-73.
24. Busso N, Frasnelli M, Feifel R, et al. Evaluation of protease-activated receptor 2 in murine models of arthritis. Arthritis Rheum 2007;56:101-7.
25. Ferrell WR, Lockhart JC, Kelso EB, et al. Essential role for proteinase-activated receptor-2 in arthritis.J Clin Invest 2003;111:35-41.
26. Kelso EB, Ferrell WR, Lockhart JC, et al. Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis Rheum 2007;56:765-71.
27. Kelso EB, Lockhart JC, Hembrough T, et al. Therapeutic promise of proteinase-activated receptor-2 antagonism in joint inflammation. J Pharmacol Exp Ther 2006;316:1017-24.
28. Masuda K, Takegami K, An H, et al. Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads. J Orthop Res 2003;21: 922-30.
29. Thompson JP, Pearce RH, Schechter MT, et al. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine1990;15:411-5.
30. Gruber BL, Marchese MJ, Santiago-Schwarz F, et al. Protease-activated receptor-2 (PAR-2) expression in human fibroblasts is regulated by growth factors and extracellular matrix. J Invest Dermatol 2004;123:832-9.
31. D'Andrea MR, Derian CK, Leturcq D, et al. Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. J Histo-chem Cytochem 1998;46:157-64.
32. McGuire JJ, Saifeddine M, Triggle CR, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther 2004;309:1124-31.
33. al-Ani B, Saifeddine M, Hollenberg MD. Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH2, in rat vascular and gastric smooth muscle. Can J Physiol Pharmacol 1995;73:1203-7.
34. Niu QX, Chen HQ, Chen ZY, et al. Induction of inflammatory cytokine release from human umbilical vein endothelial cells by agonists of proteinase-activated receptor-2. Clin Exp Pharmacol Physiol 2008;35:89-96.
35. Johansson U, Lawson C, Dabare M, et al. Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1{β}. J Leukoc Biol 2005;78:967-75.
36. Fyfe M, Bergstrom M, Aspengren S, et al. PAR-2 activation in intestinal epithelial cells potentiates interleukin-1β-induced chemokine secretion via MAP kinase signaling pathways. Cytokine 2005;31:358-67.
37. Grau S, Richards PJ, Kerr B, et al. The role of human HtrA1 in arthritic disease. J Biol Chem 2006;281:6124-9.
38. Kikuchi H, Shimada W, Nonaka T, et al. Significance of serine proteinase and matrix metalloproteinase systems in the destruction of human articular cartilage. Clin Exp Pharmacol Physiol 1996;23:885-9.
39. Martel-Pelletier J, Faure MP, McCollum R, et al. Plasmin, plasminogen activators and inhibitor in human osteoarthritic cartilage. J Rheumatol 1991;18:1863-71.
40. Freemont AJ, Jeziorska M, Hoyland JA, et al. Mast cells in the pathogenesis of chronic back pain: a hypothesis. J Pathol 2002;197:281-5.
41. Habtemariam A, Virri J, Gronblad M, et al. The role of mast cells in disc herniation inflammation. Spine1999;24:1516-20.
42. Peng B, Hao J, Hou S, et al. Possible pathogenesis of painful intervertebral disc degeneration. Spine2006;31:560-6.