Duplication of the caspase-12 prodomain and inactivation of NLRC4/IPAF in the dog

Biochemical and Biophysical Research Communications

Volumn 384, Issue 2, 2009, Pages 226-230

  Eckhart, Leopold ^a   Ballaun, Claudia ^a   Uthman, Aumaid ^a   Gawlas, Sonja ^a   Buchberger, Maria ^a   Fischer, Heinz ^a   Tschachler, Erwin ^a  

^a Universitatsklinik fur Dermatologie   (Austria)

Author keywords

Apoptosis; Caspase recruitment domain; Caspase 12; Cat; Dog; Evolution; Flagellin; Inflammasome; IPAF; NOD like receptors

Indexed keywords

CASPASE 12; ENZYME VARIANT; FLAGELLIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR;

ANIMAL CELL; ARTICLE; CAT; CONTROLLED STUDY; DOG; EMBRYO; GENE; GENE DUPLICATION; GENE INACTIVATION; GENOMICS; HUMAN; HUMAN CELL; INFLAMMATION; IPAF GENE; MUTATION; NLRC4 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM-BINDING PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; CASPASE 12; CATS; DOGS; GENE DUPLICATION; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; SEQUENCE DELETION;

CANIS FAMILIARIS; CARNIVORA;

EID: 65549146918     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.04.092     Document Type: Article

References (17)

1. Hofmann K., Bucher P., and Tschopp J. The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22 (1997) 155-156
2. Meylan E., Tschopp J., and Karin M. Intracellular pattern recognition receptors in the host response. Nature 442 (2006) 39-44
3. Hruz P., and Eckmann L. Caspase recruitment domain-containing sensors and adaptors in intestinal innate immunity. Curr. Opin. Gastroenterol. 24 (2008) 108-114
4. Franchi L., Eigenbrod T., Muñoz-Planillo R., and Nuñez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat. Immunol. 10 (2009) 241-247
5. Martinon F., and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117 (2004) 561-574
6. Fischer H., Koenig U., Eckhart L., and Tschachler E. Human caspase 12 has acquired deleterious mutations. Biochem. Biophys. Res. Commun. 293 (2002) 722-726
7. Saleh M., Vaillancourt J.P., Graham R.K., Huyck M., Srinivasula S.M., Alnemri E.S., Steinberg M.H., Nolan V., Baldwin C.T., Hotchkiss R.S., Buchman T.G., Zehnbauer B.A., Hayden M.R., Farrer L.A., Roy S., and Nicholson D.W. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429 (2004) 75-79
8. Eckhart L., Ballaun C., Hermann M., VandeBerg J.L., Sipos W., Uthman A., Fischer H., and Tschachler E. Identification of novel mammalian caspases reveals an important role of gene loss in shaping the human caspase repertoire. Mol. Biol. Evol. 25 (2008) 831-841
9. Tibbitts J. Issues related to the use of canines in toxicologic pathology--issues with pharmacokinetics and metabolism. Toxicol. Pathol. 31 (2003) S17-S24
10. Eckhart L., Ban J., Ballaun C., Weninger W., and Tschachler E. Reverse transcription-polymerase chain reaction products of alternatively spliced mRNAs form DNA heteroduplexes and heteroduplex complexes. J. Biol. Chem. 274 (1999) 2613-2615
11. Eckhart L., Ballaun C., Uthman A., Kittel C., Stichenwirth M., Buchberger M., Fischer H., Sipos W., and Tschachler E. Identification and characterization of a novel mammalian caspase with proapoptotic activity. J. Biol. Chem. 280 (2005) 35077-35080
12. Breathnach R., and Chambon P. Organization and expression of eucaryotic split genes coding for proteins. Annu. Rev. Biochem. 50 (1981) 349-383
13. Roy S., Sharom J.R., Houde C., Loisel T.P., Vaillancourt J.P., Shao W., Saleh M., and Nicholson D.W. Confinement of caspase-12 proteolytic activity to autoprocessing. Proc. Natl. Acad. Sci. USA 105 (2008) 4133-4138
14. Zamboni D.S., Kobayashi K.S., Kohlsdorf T., Ogura Y., Long E.M., Vance R.E., Kuida K., Mariathasan S., Dixit V.M., Flavell R.A., Dietrich W.F., and Roy C.R. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat. Immunol. 7 (2006) 318-325
15. Franchi L., Amer A., Body-Malapel M., Kanneganti T.D., Ozören N., Jagirdar R., Inohara N., Vandenabeele P., Bertin J., Coyle A., Grant E.P., and Núñez G. Cytosolic flagellin requires IPAF for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 7 (2006) 576-582
16. Miao E.A., Alpuche-Aranda C.M., Dors M., Clark A.E., Bader M.W., Miller S.I., and Aderem A. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via IPAF. Nat. Immunol. 7 (2006) 569-575
17. Fassy F., Krebs O., Rey H., Komara B., Gillard C., Capdevila C., Yea C., Faucheu C., Blanchet A.M., Miossec C., and Diu-Hercend A. Enzymatic activity of two caspases related to interleukin-1beta-converting enzyme. Eur. J. Biochem. 253 (1998) 76-83