Cyclic RGD-Containing functionalized azabicycloalkane peptides as potent integrin antagonists for tumor targeting

ChemMedChem

Volumn 4, Issue 4, 2009, Pages 615-632

  Manzoni, Leonardo ^a   Belvisi, Laura ^b   Arosio, Daniela ^a   Civera, Monica ^b   Pilkington Miksa, Michael ^b   Potenza, Donatella ^b   Caprini, Andrea ^b   Araldi, Elena M V ^b   Monferini, Eugenia ^b   Mancino, Monica ^c   Podesta, Francesca ^c   Scolastico, Carlo ^b  

^a CNR   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c IRCCS MULTIMEDICA   (Italy)

Author keywords

Azabicycloalkanes; Inhibitors; Integrins; Peptidomimetics; RGD motif

Indexed keywords

ALPHAVBETA5 INTEGRIN; ANGIOGENESIS INHIBITOR; ARGINYLGLYCYLASPARTIC ACID DERIVATIVE; AZABICYCLO DERIVATIVE; DRUG CARRIER; FIBRONECTIN; INTEGRIN RECEPTOR; RECEPTOR BLOCKING AGENT; ST 1646; UNCLASSIFIED DRUG; VITRONECTIN; VITRONECTIN RECEPTOR;

ANTIANGIOGENIC ACTIVITY; ARTICLE; BINDING AFFINITY; BLADDER CARCINOMA; CELL ADHESION; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TARGETING; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM;

AMIDES; AZA COMPOUNDS; CELL ADHESION; CELLS, CULTURED; COMPUTER SIMULATION; CYCLIZATION; CYCLOPARAFFINS; HUMANS; INTEGRINS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; PEPTIDES, CYCLIC; SENSITIVITY AND SPECIFICITY;

EID: 65549132157     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800422     Document Type: Article

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