Clinical validation of a link between TNF-α and the glycosylation enzyme core 2 GlcNAc-T and the relationship of this link to diabetic retinopathy

Diabetologia

Volumn 49, Issue 9, 2006, Pages 2185-2191

  Ben Mahmud, B M ^a   Chan, W H ^a   Abdulahad, R M ^a   Datti, A ^b   Orlacchio, A ^b   Kohner, E M ^a   Chibber, R ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

1,6 N acetylglucosaminyltransferase; C reactive protein; Hyperglycaemia; Leucocyte; Non proliferative diabetic retinopathy; Proliferative diabetic retinopathy; Subclinical inflammation; TNF ; Type 1 diabetes; Type 2 diabetes

Indexed keywords

CORE 2 BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; ENZYME; GLUCOSE; PROTEIN KINASE BETA 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

BLOTTING, WESTERN; C-REACTIVE PROTEIN; CELL ADHESION; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; GLYCOSYLATION; HUMANS; IMMUNOPRECIPITATION; MALE; MIDDLE AGED; N-ACETYLGLUCOSAMINYLTRANSFERASES; NEUTROPHILS; PHOSPHORYLATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33746760142     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0332-2     Document Type: Article

References (37)

1. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL (1989) The Wisconsin Epidemiologic Study of Diabetic Retinopathy. X. Four-year incidence and progression of diabetic retinopathy when age at diagnosis is 30 years or more. Arch Ophthalmol 107:244-249
2. Davis MD (1992) Diabetic retinopathy. A clinical overview. Diabetes Care 15:1844-1874
3. Kohner EM, Chibber R (1999) Diabetic retinopathy. In Tooke JE (ed) Diabetic angiopathy. Oxford University Press, pp 233-247
4. Miyamoto K, Khosrof S, Bursell SE et al (1999) Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci U S A 96:10836-10841
5. Lutty GA, Cao J, McLeod DS (1997) Relationship of polymorphonuclear leukocytes to capillary dropout in the human diabetic choroid. Am J Pathol 151:707-714
6. Joussen AM, Murata T, Tsujikawa A, Kirchhof B, Bursell SE, Adamis AP (2001) Leukocyte-mediated endothelial cell injury and death in the diabetic retina. Am J Pathol 158:147-152
7. Ishida S, Yamashiro K, Usui T et al (2003) Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease. Nat Med 9:781-788
8. Williams D, Schachter H (1980) Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates. J Biol Chem 255:11247-11252
9. Mukasa R, Homma T, Hosono O et al (1999) Human T lymphocyte populations which bind to P- or E-selectin are enriched with cells expressing core 2 O-glycans. Immunol Lett 67:117-124
10. Ben-Mahmud BM, Mann GE, Datti A, Orlacchio A, Kohner EM, Chibber R (2004) Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy. Diabetes 53:2968-2976
11. Chibber R, Ben-Mahmud BM, Coppini D, Christ E, Kohner EM (2000) Activity of the glycosylating enzyme, core 2 GlcNAc (beta1,6) transferase, is higher in polymorphonuclear leukocytes from diabetic patients compared with age-matched control subjects: relevance to capillary occlusion in diabetic retinopathy. Diabetes 49:1724-1730
12. Chibber R, Ben-Mahmud BM, Mann GE, Zhang JJ, Kohner EM (2003) Protein kinase C beta2-dependent phosphorylation of core 2 GlcNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy. Diabetes 52:1519-1527
13. Yang X, Lehotay M, Anastassiades T, Harrison M, Brockhausen I (2004) The effect of TNF-alpha on glycosylation pathways in bovine synoviocytes. Biochem Cell Biol 82:559-568
14. Ellies LG, Tsuboi S, Petryniak B, Lowe JB, Fukuda M, Marth JD (1998) Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity 9:881-890
15. Tsuboi S, Fukuda M (2001) Roles of O-linked oligosaccharides in immune responses. Bioessays 23:46-53
16. Shimodaira K, Nakayama J, Nakamura N, Hasebe O, Katsuyama T, Fukuda M (1997) Carcinoma-associated expression of core 2 beta-1,6-N- acetylglucosaminyltransferase gene in human colorectal cancer: role of O-glycans in tumor progression. Cancer Res 57:5201-5206
17. Nishio Y, Warren CE, Buczek-Thomas JA et al (1995) Identification and characterization of a gene regulating enzymatic glycosylation which is induced by diabetes and hyperglycemia specifically in rat cardiac tissue. J Clin Invest 96:1759-1767
18. Higgins EA, Siminovitch KA, Zhuang DL, Brockhausen I, Dennis JW (1991) Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome. J Biol Chem 266:6280-6290
19. Hussain MJ, Peakman M, Gallati H et al (1996) Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM. Diabetologia 39:60-69
20. Lechleitner M, Koch T, Herold M, Dzien A, Hoppichler F (2000) Tumour necrosis factor-alpha plasma level in patients with type 1 diabetes mellitus and its association with glycaemic control and cardiovascular risk factors. J Intern Med 248:67-76
21. Foss MC, Foss NT, Paccola GM, Silva CL (1992) Serum levels of tumor necrosis factor in insulin-dependent diabetic patients. Braz J Med Biol Res 25:239-242
22. Bertin E, Nguyen P, Guenounou M, Durlach V, Potron G, Leutenegger M (2000) Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are essentially dependent on visceral fat amount in type 2 diabetic patients. Diabetes Metab 26: 178-180
23. Guha M, Bai W, Nadler JL, Natarajan R (2000) Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and -independent pathways. J Biol Chem 275:17728-17739
24. Lin SJ, Shyue SK, Hung YY et al (2005) Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways. Arterioscler Thromb Vasc Biol 25:334-340
25. Kumar S, Singh BK, Kalra N et al (2005) Novel thiocoumarins as inhibitors of TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) and microsomal lipid peroxidation. Bioorg Med Chem 13:1605-1613
26. Sasakawa T, Sasakawa Y, Masunaga T et al (2005) FK506 suppresses E-selectin, ICAM-1 and VCAM-1 expression on vascular endothelial cells by inhibiting tumor necrosis factor alpha secretion from peripheral blood mononuclear cells. Cytokine 29:67-71
27. Sakurai E, Taguchi H, Anand A et al (2003) Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci 44:2743-2749
28. Joussen AM, Poulaki V, Mitsiades N et al (2002) Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression. FASEB J 16:438-440
29. Doganay S, Evereklioglu C, Er H et al (2002) Comparison of serum NO, TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus. Eye 16:163-170
30. Armstrong D, Augustin AJ, Spengler R et al (1998) Detection of vascular endothelial growth factor and tumor necrosis factor alpha in epiretinal membranes of proliferative diabetic retinopathy, proliferative vitreoretinopathy and macular pucker. Ophthalmologica 212:410-414
31. Spranger J, Meyer-Schwickerath R, Klein M, Schatz H, Pfeiffer A (1995) TNF-alpha level in the vitreous body. Increase in neovascular eye diseases and proliferative diabetic retinopathy. Med Klin (Munich) 90:134-137
32. Limb GA, Chignell AH, Green W, LeRoy F, Dumonde DC (1993) Distribution of TNF alpha and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy. Br J Ophthalmol 80:168-173
33. Slepova OS, Gerasimenko VL, Zakharova GIU, Novikova-Bilak TI (2001) Comparative study of the role of cytokines in various eye diseases. 2. Diabetic retinopathy. Vestn Oftalmol (Russian) 117:35-37
34. Kumaramanickavel G, Sripriya S, Vellanki RN et al (2001) Tumor necrosis factor allelic polymorphism with diabetic retinopathy in India. Diabetes Res Clin Pract 54:89-94
35. Smith MJ, Smith BR, Lawrence MB, Snapp KR (2004) Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N- glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectin. J Biol Chem 279:21984-21991
36. Li F, Wilkins PP, Crawley S, Weinstein J, Cummings RD, McEver RP (1996) Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin. J Biol Chem 271:3255-13264
37. Liu ZG (2005) Molecular mechanism of TNF signalling and beyond. Cell Res 15:24-27