Meniscus-assisted high-efficiency magnetic collection and separation for EWOD droplet microfluidics

Journal of Microelectromechanical Systems

Volumn 18, Issue 2, 2009, Pages 363-375

  Shah, Gaurav J ^a   Kim, Chang Jin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Collection; Droplet microfluidics; Electrowetting on dielectric (EWOD); Magnetic beads; Meniscus; Separation

Indexed keywords

COLLECTION; DROPLET MICROFLUIDICS; ELECTROWETTING-ON-DIELECTRIC (EWOD); MAGNETIC BEADS; MENISCUS;

DIELECTRIC DEVICES; DROP FORMATION; MAGNETISM; MICROFLUIDICS; SEPARATION;

MAGNETIC MATERIALS;

EID: 65449168849     PISSN: 10577157     EISSN: None     Source Type: Journal    
DOI: 10.1109/JMEMS.2009.2013394     Document Type: Article

References (45)

1. P. Gravesen, J. Branebjerg, and O. S. Jensen, "Microfluidics - A review," J. Micromech. Microeng., vol. 3, no. 4, pp. 168-182, Dec. 1993.
2. S. Pennathur, C. D. Meinhart, and H. T. Soh, "How to exploit the features of microfluidics technology," Lab Chip, vol. 8, no. 1, pp. 20-22, Jan. 2008.
3. K. M. Horsman, J. M. Bienvenue, K. R. Blasier, and J. P. Landers, "Forensic DNA analysis on microfluidic devices: A review," J. Forensic Sci., vol. 52, no. 4, pp. 784-799, Jul. 2007.
4. S. Mouradian, "Lab-on-a-chip: Applications in proteomics," Curr. Opin. Chem. Biol., vol. 6, no. 1, pp. 51-56, Feb. 2002.
5. H. Andersson and A. van den Berg, "Microfluidic devices for cellomics: A review," Sens. Actuators B, Chem., vol. 92, no. 3, pp. 315-325, Jul. 2003.
6. P. S. Dittrich, K. Tachikawa, and A. Manz, "Micro total analysis systems. Latest advancements and trends," Anal. Chem., vol. 78, no. 12, pp. 3887-3907, 2006.
7. A. G. Crevillen, M. Hervas, M. A. Lopez, M. C. Gonzalez, and A. Escarpa, "Real sample analysis on microfluidic devices," Talanta, vol. 74, no. 3, pp. 342-357, Dec. 2007.
8. C. Q. Yi, C. W. Li, S. L. Ji, and M. S. Yang, "Microfluidics technology for manipulation and analysis of biological cells," Anal. Chim. Acta vol. 560, no. 1/2, pp. 1-23, Feb. 2006.
9. N. Pamme, "Magnetism and microfluidics," Lab Chip, vol. 6, no. 1, pp. 24-38, 2006.
10. K. H. Han and A. B. Frazier, "Paramagnetic capture mode magnetophoretic microseparator for high efficiency blood cell separations," Lab Chip vol. 6, no. 2, pp. 265-273, Feb. 2006.
11. M. A. M. Gijs, "Magnetic bead handling on-chip: New opportunities for analytical applications," Microfluidics Nanofluidics, vol. 1, no. 1, pp. 22-40, Nov. 2004.
12. J. W. Choi, K. W. Oh, J. H. Thomas, W. R. Heineman, H. B. Halsall, J. H. Nevin, A. J. Helmicki, H. T. Henderson, and C. H. Ahn, "An integrated microfluidic biochemical detection system for protein analysis with magnetic bead-based sampling capabilities," Lab Chip, vol. 2, no. 1, pp. 27-30, Feb. 2002.
13. K. S. Kim and J. K. Park, "Magnetic force-based multiplexed immunoassay using superparamagnetic nanoparticles in microfluidic channel," Lab Chip, vol. 5, no. 6, pp. 657-664, Jun. 2005.
14. V. I. Furdui and D. J. Harrison, "Immunomagnetic T cell capture from blood for PCR analysis using microfluidic systems," Lab Chip, vol. 4, no. 6, pp. 614-618, Dec. 2004.
15. N. Xia, T. P. Hunt, B. T. Mayers, E. Alsberg, G. M. Whitesides, R. M. Westervelt, and D. E. Ingber, "Combined microfluidic-micromagnetic separation of living cells in continuous flow," Biomed. Microdevices vol. 8, no. 4, pp. 299-308, Dec. 2006.
16. S. K. Cho, H. J. Moon, and C.-J. Kim, "Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits," J. Microelectromech. Syst., vol. 12, no. 1, pp. 70-80, Feb. 2003.
17. V. Srinivasan, V. K. Pamula, and R. B. Fair, "An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids," Lab Chip, vol. 4, no. 4, pp. 310-315, Aug. 2004.
18. H. J. Moon, A. R. Wheeler, R. L. Garrell, J. A. Loo, and C.-J. Kim, "An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS," Lab Chip, vol. 6, no. 9, pp. 1213-1219, Sep. 2006.
19. R. B. Fair, A. Khlystov, T. D. Tailor, V. Ivanov, R. D. Evans, P. B. Griffin, V. Srinivasan, V. K. Pamula, M. G. Pollack, and J. Zhou, "Chemical and biological applications of digital-microfluidic devices," IEEE Des. Test Comput., vol. 24, no. 1, pp. 10-24, Jan./Feb. 2007.
20. S. K. Cho, Y. J. Zhao, and C.-J. Kim, "Concentration and binary separation of microparticles for droplet-based digital microfluidics," Lab Chip, vol. 7, no. 4, pp. 490-498, Apr. 2007.
21. G. J. Shah, P. Y. Chiou, J. Gong, A. T. Ohta, J. B. Chou, M. C. Wu, and C.-J. Kim, "Integrating optoelectronic tweezers for individual particle manipulation with digital microfluidics using electrowetting-on-dielectric," in Proc. IEEE Int. Conf. MEMS, Istanbul, Turkey, Jan. 2006, pp. 129-132.
22. Y. J. Zhao, U. C. Yi, and S. K. Cho, "Microparticle concentration and separation by traveling-wave dielectrophoresis (twDEP) for digital microfluidics," J. Microelectromech. Syst., vol. 16, no. 6, pp. 1472-1481, Dec. 2007.
23. G. J. Shah, E. Pierstorff, D. Ho, and C.-J. Kim, "Meniscus-assisted magnetic bead trapping on EWOD-based digital microfluidics for specific protein localization," in Proc. Int. Conf. Solid-State Sens., Actuators Microsyst., Lyon, France, Jun. 2007, pp. 707-710.
24. Y. Z. Wang, Y. Zhao, and S. K. Cho, "Efficient in-droplet separation of magnetic particles for digital microfluidics," J. Micromech. Microeng., vol. 17, no. 10, pp. 2148-2156, Oct. 2007.
25. T. Ohashi, H. Kuyama, K. Suzuki, and S. Nakamura, "Control of aqueous droplets using magnetic and electrostatic forces," Anal. Chim. Acta vol. 612, no. 2, pp. 218-225, Apr. 2008.
26. Y. Fouillet, D. Jary, C. Chabrol, P. Claustre, and C. Peponnet, "Digital microfluidic design and optimization of classic and new fluidic functions for lab on a chip systems," Microfluidics Nanofluidics, vol. 4, no. 3, pp. 159-165, Mar. 2008.
27. R. S. Sista, A. E. Eckhardt, V. Srinivasan, M. G. Pollack, S. Palanki, and V. K. Pamula, "Heterogeneous immunoassays using magnetic beads on a digital microfluidic platform," Lab Chip, vol. 8, no. 12, pp. 2188-2196, Dec. 2008.
28. M. G. Pollack, R. B. Fair, and A. D. Shenderov, "Electrowetting-based actuation of liquid droplets for microfluidic applications," Appl. Phys. Lett., vol. 77, no. 11, pp. 1725-1726, Sep. 2000.
29. Y. Fouillet and J. L. Achard, "Digital microfluidic and biotechnology," C. R. Phys., vol. 5, pp. 577-588, 2004.
30. F. Mugele, A. Klingner, J. Buehrle, D. Steinhauser, and S. Herminghaus, "Electrowetting: A convenient way to switchable wettability patterns," J. Phys., Condens. Matter, vol. 17, no. 9, pp. S559-S576, Mar. 2005.
31. J. Lee, H. Moon, J. Fowler, T. Schoellhammer, and C.-J. Kim, "Electrowetting and electrowetting-on-dielectric for microscale liquid handling," Sens. Actuators B, Chem., vol. 95, no. 2, pp. 259-268, Jan. 2002.
32. H. J. Moon, S. K. Cho, R. L. Garrell, and C.-J. Kim, "Low voltage electrowetting-on-dielectric," J. Appl. Phys., vol. 92, no. 7, pp. 4080-4087, 2002.
33. R. B. Fair, "Digital microfluidics: Is a true lab-on-a-chip possible?" Microfluidics Nanofluidics, vol. 3, no. 3, pp. 245-281, Jun. 2007.
34. J. Y. Yoon and R. L. Garrell, "Preventing biomolecular adsorption in electrowetting-based biofluidic chips," Anal. Chem., vol. 75, no. 19, pp. 5097-5102, 2003.
35. H. Moon, "Electrowetting-on-dielectric microfluidics: Modeling, physics, and MALDI application," Ph.D. dissertation, Univ. California, Los Angeles, CA, 2005.
36. G. J. Shah, J. L. Veale, Y. Korin, E. F. Reed, H. A. Gritsch, and C.-J. Kim, "Concentration of CD8+ lymphocytes on EWOD Platform for monitoring organ transplant rejection," in Proc. Solid-State Sens., Actuators Microsyst. Workshop, Hilton Head Island, SC, Jun. 2008, pp. 28-31.
37. Y. J. Zhao and S. K. Cho, "Microparticle sampling by electrowetting-actuated droplet sweeping," Lab Chip, vol. 6, no. 1, pp. 137-144, Jan. 2006.
38. J. Visser, "Particle adhesion and removal: A review," Part. Sci. Technol., vol. 13, no. 3/4, pp. 169-196, 1995.
39. Y. Zhao and S. K. Cho, "A micro particle sampler using electrowetting-actuated droplet sweeping," in Proc. Int. Conf. Solid-State Sens., Actuators Microsyst., Jun. 2005, vol. 1, pp. 129-134.
40. I. Safarik and M. Safarikova, "Use of magnetic techniques for the isolation of cells," J. Chromatogr. B, vol. 722, no. 1/2, pp. 33-53, Feb. 1999.
41. K. Tanaka and H. Imagawa, "Rapid and reagent-saving immunoassay using innovative stirring actions of magnetic beads in microreactors in the sequential injection mode," Talanta, vol. 68, no. 2, pp. 437-441, Dec. 2005.
42. P. D. Becker, G. M. Bertot, D. Souss, T. Ebensen, C. A. Guzman, and S. Grinstein, "Intranasal vaccination with recombinant outer membrane protein CD and adamantylamide dipeptide as the mucosal adjuvant enhances pulmonary clearance of moraxella catarrhalis in an experimental murine model," Infect. Immun., vol. 75, no. 4, pp. 1778-1784, Apr. 2007.
43. H. W. Lu, F. Bottausci, J. D. Fowler, A. L. Bertozzi, C. Meinhart, and C.-J. Kim, "A study of EWOD-driven droplets by PIV investigation," Lab Chip, vol. 8, no. 3, pp. 456-461, Mar. 2008.
44. 140 11.Dynabeads M450 Epoxy(rev002).pdf (application/pdf Object). Last modified: Dec. 4, 2008. Last accessed Feb. 4, 2009. [Online]. Available: http://tools.invitrogen.com/content/sfs/manuals/ 140%2011.Dynabeads%20M450%20Epoxy(rev002).pdf
45. Streptavidin-coupled Dynabeads, Streptavidin Magnetic Beads. Last modified: Feb. 3, 2009. Last accessed Feb. 4, 2009. [Online]. Available: http://www.invitrogen.com/site/us/en/home/brands/Dyna1/ Streptavidin-Coupled-Dynabeads.html