Molecular Genetic Changes Associated With Colorectal Carcinogenesis Are Not Prognostic for Tumor Regression Following Preoperative Chemoradiation of Rectal Carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 74, Issue 2, 2009, Pages 472-476

  Zauber, N Peter ^a   Marotta, Steven P ^a   Berman, Errol ^a   Grann, Alison ^a   Rao, Maithili ^a   Komati, Naga ^a   Ribiero, Kezia ^a   Bishop, D Timothy ^b  

^a SAINT BARNABAS MEDICAL CENTER   (United States)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

APC gene; DCC gene; K ras gene; Microsatellite instability; Preoperative chemoradiation; Rectal cancer

Indexed keywords

APC GENE; DCC GENE; K-RAS GENE; MICROSATELLITE INSTABILITY; PREOPERATIVE CHEMORADIATION; RECTAL CANCER;

CHEMICAL PLANTS; CHEMOTHERAPY; GENES; MICROWAVE ANTENNAS; NUCLEIC ACIDS; PATHOLOGY; STABILITY; TUMORS;

REGRESSION ANALYSIS;

FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; APC GENE; ARTICLE; CANCER REGRESSION; COLONOSCOPY; COLORECTAL CARCINOMA; DCC GENE; DISEASE ASSOCIATION; DNA SEQUENCE; FEMALE; GENE; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MOLECULAR GENETICS; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROGNOSIS; RECTUM CARCINOMA; SINGLE STRAND CONFORMATION POLYMORPHISM;

AGED; BIOPSY; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; GENES, APC; GENES, DCC; GENES, RAS; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE INSTABILITY; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PREOPERATIVE CARE; PROGNOSIS; PROSPECTIVE STUDIES; RECTAL NEOPLASMS; RECTUM; REMISSION INDUCTION;

EID: 65449165179     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.08.020     Document Type: Article

References (32)

1. American Cancer Society. Cancer Facts & Figures 2008 (2008), American Cancer Society, Atlanta
2. Grann A., Feng C., Wong D., et al. Preoperative combined modality therapy for clinically respectable UT3 rectal adenocarcinoma. Int J Radiation Biol Phys 49 (2001) 987-995
3. Goldberg P.A., Nicholls R.J., Porter N.H., et al. Long-term results of a randomised trial of short-course low-dose adjuvant preoperative radiotherapy for rectal cancer: Reduction in local treatment failure. Eur J Cancer 30A (1994) 1602-1606
4. Cedermark B., Johansson H., Rutqvist L.E., and Wilking N. The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma: A prospective randomized trial. Cancer 75 (1995) 2269-2275
5. Medical Research Council Rectal Cancer Working Party. Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer. Lancet 348 (1996) 1610-1614
6. Janjan N.A., Crane C., Feig B.W., et al. Improved overall survival among responders to pre-operative chemoradiation for locally advanced rectal cancer. Am J Clin Oncol 24 (2001) 107-112
7. Crane C.H., Skibber J.M., Feig B.W., et al. Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma. Cancer 97 (2003) 517-524
8. Liersch T., Langer C., Ghadimi B.M., et al. Lymph node status and TS gene expression are prognostic markers in Stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy. J Clin Oncol 24 (2006) 4062-4068
9. Tjandra J.J., Reading D.M., McLachlan S.A., et al. Phase II clinical trial of preoperative combined chemoradiation for T3 and T4 resectable rectal cancer. Dis Colon Rectum 44 (2001) 1113-1122
10. Grann A., and Zauber P. Is there a predictive value for molecular markers in predicting response to radiation and chemotherapy in rectal cancer?. Int J Radiation Oncology Biol Phys 54 (2002) 1286-1287
11. Wheeler J.M.D., Dodds E., Warren B.F., et al. Preoperative chemoradiotherapy and total mesorectal excision surgery for locally advanced rectal cancer: Correlation with rectal cancer regression grade. Dis Colon Rectum 47 (2004) 2025-2031
12. Zauber N.P., Solitare M., Marotta S.P., et al. Comparison of allelic ratios from paired blood and paraffin-embedded normal tissue for use in a PCR to assess loss of heterozygosity. Mol Diagn 4 (1999) 29-34
13. Smith F.M., Reynolds J.V., Miller N., et al. Pathological and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy. European J Surg Oncol 32 (2006) 55-64
14. Janjan N.A., Khoo V.S., Abbruzzese J., et al. Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer: the M.D. Anderson cancer center experience. Int J Radiation Biol Phys 44 (1999) 1027-1038
15. Das P., Skibber J.M., Bigas M.A., et al. Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer. Cancer 109 (2007) 1750-1755
16. Willett C.G., Warland G., Coen J., et al. Rectal cancer: The influence of tumor proliferation on response to preoperative irradiation. Int J Radiation Oncology Biol Phys 32 (1995) 57-61
17. Zlobec I., Steele R., and Compton C.C. VEGF as a predictive marker of rectal tumor response to preoperative radiotherapy. Cancer 104 (2005) 2517-2521
18. Spindler K.L.G., Nielsen J.N., Lindebjerg J., and Jakobsen A. Germline polymorphisms may act as predictors of response to preoperative chemoradiation in locally advanced T3 rectal tumors. Dis Colon Rectum 50 (2007) 1363-1369
19. Francois Y., Nemoz C.J., Baulieux J., et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: The Lyon R90-01 randomized trial. J Clin Oncol 17 (1999) 2396-2402
20. Crapez E.L., Bibeau F., Thezenas S., et al. p53 status and response to radiotherapy in rectal cancer: a prospective multilevel analysis. Br J Cancer 92 (2005) 2114-2121
21. Chang H.J., Jung K.H., Kim D.Y., et al. Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. Human Pathology 36 (2005) 364-371
22. Saw R.P.M., Morgan M., Koorey D., et al. P53, Deleted in colorectal cancer gene, and thymidylate synthase as predictors of histopathologic response and survival in low, locally advanced rectal cancer treated with preoperative adjuvant therapy. Dis Colon Rectum 46 (2003) 192-202
23. Charara M., Edmonston T.B., Burkholder S., et al. Microsatellite status and cell cycle associated markers in rectal cancer patients undergoing a combined regimen of 5-FU and CPT-11 chemotherapy and radiotherapy. Anticancer Res 24 (2004) 3161-3167
24. Rau B., Sturm I., Lage H., et al. Dynamic expression profile of p21WAF1/C1P1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. J Clin Oncol 21 (2003) 3391-33401
25. Qiu H., Sirivongs P., Rothenberger M., et al. Molecular prognostic factors in rectal cancer treated by radiation and surgery. Dis Colon Rectum 43 (2000) 451-459
26. Calvert P.M., and Frucht H. The genetics of colorectal cancer. Ann Intern Med 137 (2002) 603-612
27. Sklar M.D. The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation. Science 239 (1988) 645-647
28. Grant M.L., Bruton R.K., Byrd P.J., et al. Sensitivity to ionizing radiation of transformed human cells containing mutant ras genes. Oncogene 5 (1990) 1159-1164
29. Ware J.H. The limitations of risk factors as prognostic tools. N Engl J Med 355 (2006) 2615-2617
30. Rodel C., Grabenbauser G.G., Papodopoulos T., et al. Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. Int J Radiation Oncology Biol Phys 52 (2002) 294-303
31. Kim I.J., Lim S.B., Kang H.C., et al. Microarray gene expression profiling for predicting complete response to preoperative chemoradiotherapy in patients with advanced rectal cancer. Dis Colon Rectum 50 (2007) 1342-1353
32. Watanabe T., Komuro Y., Kiyomatsu T., et al. Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles. Cancer Res 66 (2006) 3370-3374