Germline polymorphisms may act as predictors of response to preoperative chemoradiation in locally advanced T3 rectal tumors

Diseases of the Colon and Rectum

Volumn 50, Issue 9, 2007, Pages 1363-1369

  Spindler, Karen Lise G ^a   Nielsen, Jens N ^a   Lindebjerg, Jan ^a   Jakobsen, Anders ^a  

^a LILLEBAELT HOSPITAL   (Denmark)

Author keywords

Epidermal growth factor A61G; Epidermal growth factor receptor Sp1 216; Polymorphisms; Preoperative chemoradiation; Rectal cancer; Thymidylate synthase

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR A61G; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR SP1 216; FOLINIC ACID; THYMIDYLATE SYNTHASE; UFT; UNCLASSIFIED DRUG;

ADULT; ADVANCED CANCER; ARTICLE; BLOOD SAMPLING; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; GERM LINE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOLOGY; POLYMERASE CHAIN REACTION; PREDICTION; PREDICTOR VARIABLE; PREOPERATIVE CARE; RADIATION DOSE; RECTUM RESECTION; RECTUM TUMOR; TREATMENT RESPONSE; TUMOR REGRESSION;

ANTINEOPLASTIC AGENTS; COLECTOMY; COMBINED MODALITY THERAPY; DNA, NEOPLASM; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROGNOSIS; RADIOTHERAPY, ADJUVANT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECTAL NEOPLASMS; THYMIDYLATE SYNTHASE;

EID: 34748922950     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/s10350-007-0264-z     Document Type: Article

References (33)

1. RJ Heald BJ Moran RD Ryall R Sexton JK MacFarlane 1998 Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997 Arch Surg 133 894 899
2. E Kapiteijn CA Marijnen ID Nagtegaal 2001 Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer N Engl J Med 345 638 646
3. CA Marijnen ID Nagtegaal E Kapiteijn 2003 Radiotherapy does not compensate for positive resection margins in rectal cancer patients: report of a multicenter randomized trial Int J Radiat Oncol Biol Phys 55 1311 1320
4. JP Gerard O Chapet C Nemoz 2004 Improved sphincter preservation in low rectal cancer with high-dose preoperative radiotherapy: the Lyon R96-02 randomized trial J Clin Oncol 22 2404 2409
5. A Jakobsen JP Mortensen C Bisgaard J Lindebjerg JW Hansen SR Rafaelsen 2006 Preoperative chemoradiation of locally advanced T3 rectal cancer combined with an endorectal boost Int J Radiat Oncol Biol Phys 64 461 465
6. CH Crane JM Skibber BW Feig 2003 Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma Cancer 97 517 524
7. JF Bosset G Calais L Mineur 2005 Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results-EORTC 22921 J Clin Oncol 23 5620 5627
8. K Bujko MP Nowacki A Nasierowska-Guttmejer 2004 Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy Radiother Oncol 72 15 24
9. G Theodoropoulos WE Wise A Padmanabhan 2002 T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival Dis Colon Rectum 45 895 903
10. FM Vecchio V Valentini BD Minsky 2005 The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer Int J Radiat Oncol Biol Phys 62 752 760
11. F Bozzetti S Andreola D Baratti 2002 Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response Ann Surg Oncol 9 444 449
12. H Bouzourene FT Bosman W Seelentag M Matter P Coucke 2002 Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy Cancer 94 1121 1130
13. P Luna-Perez S Rodriguez-Ramirez J Vega E Sandoval S Labastida 2001 Morbidity and mortality following abdominoperineal resection for low rectal adenocarcinoma Rev Invest Clin 53 388 395
14. A Habr-Gama RO Perez W Nadalin 2004 Operative vs. nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results Ann Surg 240 711 717
15. S Popat A Matakidou RS Houlston 2004 Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis J Clin Oncol 22 529 536
16. K Kawakami D Salonga JM Park 2001 Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression Clin Cancer Res 7 4096 4101
17. ST Pullarkat J Stoehlmacher V Ghaderi 2001 Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy Pharmacogenomics J 1 65 70
18. A Jakobsen JN Nielsen N Gyldenkerne J Lindeberg 2005 Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity J Clin Oncol 23 1365 1369
19. E Villafranca Y Okruzhnov MA Dominguez 2001 Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer J Clin Oncol 19 1779 1786
20. M Shahbazi V Pravica N Nasreen 2002 Association between functional polymorphism in EGF gene and malignant melanoma Lancet 359 397 401
21. L Milas Z Fan NH Andratschke KK Ang 2004 Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies Int J Radiat Oncol Biol Phys 58 966 971
22. J Giralt HM de las L Cerezo 2005 The expression of epidermal growth factor receptor results in a worse prognosis for patients with rectal cancer treated with preoperative radiotherapy: a multicenter, retrospective analysis Radiother Oncol 74 101 108
23. D Azria F Bibeau N Barbier 2005 Prognostic impact of epidermal growth factor receptor (EGFR) expression on loco-regional recurrence after preoperative radiotherapy in rectal cancer BMC Cancer 5 62
24. W Liu F Innocenti MH Wu 2005 A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter Cancer Res 65 46 53
25. KL Spindler JN Nielsen J Lindebjerg I Brandslund A Jakobsen 2006 Prediction of response to chemoradiation in rectal cancer by a gene polymorphism in the epidermal growth factor receptor promoter region Int J Radiat Oncol Biol Phys 66 500 504
26. W Zhang M Gordon OA Press 2006 Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab Pharmacogenet Genomics 16 475 483
27. JW Hansen A Jakobsen 2006 The importance of applicator design for intraluminal brachytherapy of rectal cancer Med Phys 33 3220 3224
28. B Iacopetta F Grieu D Joseph H Elsaleh 2001 A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil Br J Cancer 85 827 830
29. SP Hiotis SM Weber AM Cohen 2002 Assessing the predictive value of clinical complete response to neoadjuvant therapy for rectal cancer: an analysis of 488 patients J Am Coll Surg 194 131 135
30. C Chung-Kang M Ohno K Nishimura Y Kuroda 2006 Intratumoral heterogeneous expression of thymidylate synthase in gastric cancer Hepatogastroenterology 53 458 462
31. J Giralt A Eraso M Armengol 2002 Epidermal growth factor receptor is a predictor of tumor response in locally advanced rectal cancer patients treated with preoperative radiotherapy Int J Radiat Oncol Biol Phys 54 1460 1465
32. FM Smith JV Reynolds N Miller RB Stephens MJ Kennedy 2006 Pathologic and molecular predictors of the response of rectal cancer to neoadjuvant radiochemotherapy Eur J Surg Oncol 32 55 64
33. MA Gordon J Gil B Lu 2006 Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation Pharmacogenomics 7 67 88