Synthesis and modifications of a small library of 1,4-benzodiazepin-3-ones toward potential inhibitors of the collagen-von Willebrand Factor interaction

Tetrahedron

Volumn 65, Issue 23, 2009, Pages 4521-4529

  Deschrijver, Tiny ^a   Verwilst, Peter ^a   Broos, Katleen ^a   Deckmyn, Hans ^a   Dehaen, Wim ^a   De Borggraeve, Wim M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

(2 FLUORO 5 NITROPHENYL)N(4 METHOXYLBENZYL)METHANAMINE; 1 ALLYL 2 (4 TERT BUTOXYBENZYL) 7 NITRO 1,2,4,5 TETRAHYDRO 4H 1,4 BENZODIAZEPIN 3 ONE; 1 BENZYL 2 (4 TERT BUTOXYBENZYL) 4 (4 METHOXYBENZYL) 7 NITRO 1,2,4,5 TETRAHYDRO 3H 1,4 BENZODIAZEPIN 3 ONE; 1 PHENYL 2 (4 TERT BUTOXYBENZYL) 4 (4 METHOXYBENZYL) 7 NITRO 1,2,4,5 TETRAHYDRO 3H 1,4 BENZODIAZEPIN 3 ONE; 2 (4 HYDROXYBENZYL) 4 [2 (4 HYDROXYPHENYL)ETHYL] 7 NITRO 1,2,4,5 TETRA HYDRO 3H 1,4 BENZODIAZEPINE 3 ONE; 2 (4 TERT BUTOXYBENZYL) 4 (4 METHOXYBENZYL) 7 NITRO 1,2,4,5 TETRAHYDRO 3H 1,4 BENZODIAZEPIN 3 ONE; 2 (4 TERT BUTOXYLBENZYL) 1 ETHYL 4 (4 METHOXYBENZYL) 7 NITRO 1,2,4,5 TETRAHYDRO 3H 1,4 BENZODIAZEPIN 3 ONE; 2 [4 (4 HYDROXYBENZYL) 7 NITRO 3 OXO 2,3,4,5 TETRAHYDRO 1 H 1,4 BENZO DIAZEPIN 2 YL]ACETAMIDE; 2 [4 (4 HYDROXYBENZYL) 7 NITRO 3 OXO 2,3,4,5 TETRAHYDRO 1H 1,4 BENZO DIAZEPIN 2 YL]ACETAMIDE; 2 [4 (4 METHOXYBENZYL) 1 METHYL 7 NITRO 3 OXO TETRAHYDRO 1H 1,4 BENZODIAZEPIN 2 YL]N TRITYLACETAMIDE; 2 [4 (4 METHOXYBENZYL) 7 NITRO 3 OXO 1,3,4,5 TETRAHYDRO 2H 1,4 BENZODIAZEPIN 2 YLIDENE]N TRITYLETHANAMIDE; 2 [7 (ACETYLAMINO) 4 (4 METHOXYBENZYL) 3 OXO 2,3,4,5 TETRAHYDRO 1H 1,4 BENZODIAZEPIN 2 YL]N TRITYLACETAMIDE; 2 AMINO 3 (4 TERT BUTOXYPHENYL) N (2 FLUORO 5 NITROBENZYL)N[2 (4 METHOXYPHENYL)ETHYL]PROPANAMIDE; 2 AMINO 3 (4 TERT BUTOXYPHENYL)N(2 FLUORO 5 NITROBENZYL)N(4 METHOXYBENZYL)PROPANAMIDE; 2 AMINO N1 (2 FLUORO 5 NITROBENZYL)N1(4 METHOXYBENZYL)N4 TRITYL SUCCINAMIDE; 7 AMINO 2 (4 TERT BUTOXYBENZYL) 4 [2 (4 METHOXYPHENYL)ETHYL] 1,2,4,5 TETRAHYDRO 3H 1,4 BENZODIAZEPIN 3 ONE; 82D6A3; 9H FLUOREN 9 YLMETHYL 1 (4 TERT BUTOXYBENZYL) 2 [(2 FLUORO 5 NITROBENZYL)(4 METHOXYBENZYL)AMINO] 2 OXOETHYLCARBAMATE; 9H FLUOREN 9 YLMETHYL 2 [(2 FLUORO 5 NITROBENZYL)(4 METHOXYBENZYL)AMINO] 2 OXO 1 [(TRITYLAMINO)CARBONYL]ETHYLCARBAMATE; ANTICOAGULANT AGENT; BENZODIAZEPINE DERIVATIVE; COLLAGEN TYPE 3; N(2 FLUORO 5 NITROBENZYL) 2 (4 METHOXYPHENYL)ETHANAMINE; N1 [2 (4 TERT BUTOXYBENZYL) 4 [2 (4 METHOXYPHENYL)ETHYL] 3 OXO 2,3,4,5 TETRAHYDRO 1H 1,4 BENZODIAZEPIN 7 YL] N4 TRITYLASPARTAMIDE; N1 [2 (4 TERT BUTOXYBENZYL) 4 [2 (4 METHOXYPHENYL)ETHYL] 3 OXO 2,3,4,5 TETRAHYDRO 1H 1,4 BENZODIAZEPIN 7 YL]O(TERT BUTYL)ASPARAGINATE; N[2 (4 TERT BUTOXYBENZYL) 4 (4 METHOXYBENZYL) 3 OXO 2,3,4,5 TETRA HYDRO 1H 1,4 BENZODIAZEPINE 6 YL]ACETAMIDE; N[2 (4 TERT BUTOXYBENZYL) 4 [2 (4 METHOXYPHENYL)ETHYL] 3 OXO 2,3,4,5 TETRAHYDRO 1H 1,4 BENZODIAZEPIN 7 YL]ACETAMIDE; N[2 [4 TERT BUTOXYBENZYL) 4 [2 (4 METHOXYPHENYL)ETHYL] 3 OXO 2,3,4,5 TETRAHYDRO 1H 1,4 BENZODIAZEPIN 7 YL]O(TERT BUTYL)TYROSINAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VON WILLEBRAND FACTOR;

ACYLATION; ALKYLATION; ANTICOAGULATION; ARTICLE; CHEMICAL MODIFICATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG SYNTHESIS; MOLECULAR LIBRARY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REDUCTION;

EID: 65449145212     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.03.095     Document Type: Article

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