A consensus tetrapeptide selected by phage display adopts the conformation of a dominant discontinuous epitope of a monoclonal anti-VWF antibody that inhibits the von Willebrand factor-collagen interaction

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37815-37821

  Vanhoorelbeke, Karen ^a   Depraetere, Hilde ^a   Romijn, Roland A P ^b   Huizinga, Eric G ^b,c   De Maeyer, Marc ^a   Deckmyn, Hans ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; COLLAGEN; MOLECULAR STRUCTURE; MUTAGENESIS;

FIBRILLAR COLLAGENS;

POLYPEPTIDES;

ALANINE; AMINO ACID; ARGININE; ASPARTIC ACID; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; EPITOPE; FIBRILLAR COLLAGEN; HISTIDINE; METHIONINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 82D6A3; PROLINE; SERINE; TETRAPEPTIDE; TRYPTOPHAN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN STRUCTURE; ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MIMICRY; MOLECULAR MODEL; MUTATIONAL ANALYSIS; NONHUMAN; NORMAL HUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; COLLAGEN; EPITOPE MAPPING; EPITOPES; HUMANS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN CONFORMATION; VON WILLEBRAND FACTOR;

ANIMALIA;

EID: 0141733103     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304289200     Document Type: Article

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