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Volumn 24, Issue 4, 2009, Pages 1121-1129

Expression of gremlin, a bone morphogenetic protein antagonist,is associated with vascular calcification in uraemia

Author keywords

BMP 2; BMP 7 antagonist; CKD; Gremlin; Vascular calcification

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CALCITRIOL; CYTOKINE RECEPTOR ANTAGONIST; GREMLIN; MESSENGER RNA; OSTEOGENIC PROTEIN 1; UNCLASSIFIED DRUG;

EID: 65349196385     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn611     Document Type: Article
Times cited : (16)

References (35)
  • 1
    • 0023019674 scopus 로고
    • Aortic calcification as a predictor of cardiovascular mortality
    • Witteman JC, Kok FJ, van Saase JL et al. Aortic calcification as a predictor of cardiovascular mortality. Lancet 1986; 2: 1120-1122
    • (1986) Lancet , vol.2 , pp. 1120-1122
    • Witteman, J.C.1    Kok, F.J.2    van Saase, J.L.3
  • 2
    • 0035916881 scopus 로고    scopus 로고
    • Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality
    • Wilson PWF, Kauppila LI, O'Donnell CJ et al. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation 2001; 103: 1529-1534
    • (2001) Circulation , vol.103 , pp. 1529-1534
    • Wilson, P.W.F.1    Kauppila, L.I.2    O'Donnell, C.J.3
  • 3
    • 0042885985 scopus 로고    scopus 로고
    • Arterial media calcification in end-stage renal disease: Impact on all-cause and cardiovascular mortality
    • London GM, Guerin AP, Marchais SJ et al. Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transplant 2003; 18: 1731-1740
    • (2003) Nephrol Dial Transplant , vol.18 , pp. 1731-1740
    • London, G.M.1    Guerin, A.P.2    Marchais, S.J.3
  • 4
    • 27444432773 scopus 로고    scopus 로고
    • Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    • London GM, Marchais SJ, Guerin AP et al. Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia. Curr Opin Nephrol Hypertens. 2005; 14: 525-531
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 525-531
    • London, G.M.1    Marchais, S.J.2    Guerin, A.P.3
  • 5
    • 33847223412 scopus 로고    scopus 로고
    • Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients
    • Block GA, Raggi P, Bellasi A et al. Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients. Kidney Int 2007; 71: 438-441
    • (2007) Kidney Int , vol.71 , pp. 438-441
    • Block, G.A.1    Raggi, P.2    Bellasi, A.3
  • 6
    • 0034682247 scopus 로고    scopus 로고
    • Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis
    • Goodman WG, Goldin J, Kuizon BD et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000; 342: 1478-1483
    • (2000) N Engl J Med , vol.342 , pp. 1478-1483
    • Goodman, W.G.1    Goldin, J.2    Kuizon, B.D.3
  • 7
    • 0034922853 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of vascular calcification in end-stage renal disease
    • Davies MR, Hruska KA. Pathophysiological mechanisms of vascular calcification in end-stage renal disease. Kidney Int 2001; 60: 472- 479
    • (2001) Kidney Int , vol.60 , pp. 472-479
    • Davies, M.R.1    Hruska, K.A.2
  • 8
    • 0033598796 scopus 로고    scopus 로고
    • Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis
    • Shananhan CM, Cary N, Salisbury JR et al. Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis. Circulation 1999; 100: 2168-2176
    • (1999) Circulation , vol.100 , pp. 2168-2176
    • Shananhan, C.M.1    Cary, N.2    Salisbury, J.R.3
  • 9
    • 0018748311 scopus 로고
    • Arterial calcification and pathology in uremic patients undergoing dialysis
    • Ibels LS, Alfrey AC, Huffer WE et al. Arterial calcification and pathology in uremic patients undergoing dialysis. Am J Med 1979; 66: 790-796
    • (1979) Am J Med , vol.66 , pp. 790-796
    • Ibels, L.S.1    Alfrey, A.C.2    Huffer, W.E.3
  • 10
    • 0034730291 scopus 로고    scopus 로고
    • Phosphate regulation of vascular smooth muscle cell calcification
    • Jono S, McKeeMD, Murry CE et al. Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 2000; 87: E10-E17
    • (2000) Circ Res , vol.87
    • Jono, S.1    McKee, M.D.2    Murry, C.E.3
  • 11
    • 4644231530 scopus 로고    scopus 로고
    • Pathophysiology of vascular calcification in chronic kidney disease
    • Moe SM, Chen NX. Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 2004; 95: 560-567
    • (2004) Circ Res , vol.95 , pp. 560-567
    • Moe, S.M.1    Chen, N.X.2
  • 13
    • 0037337818 scopus 로고    scopus 로고
    • Uremia induces the osteoblast differentiation factor Cbfa-1 in human blood vessels
    • Moe S, Duan D, Doehle BP et al. Uremia induces the osteoblast differentiation factor Cbfa-1 in human blood vessels. Kidney Int 2003; 63: 1003-1011
    • (2003) Kidney Int , vol.63 , pp. 1003-1011
    • Moe, S.1    Duan, D.2    Doehle, B.P.3
  • 14
    • 0036151662 scopus 로고    scopus 로고
    • Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins
    • Moe S, O-Neill K, Duan D et al. Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins. Kidney Int 2002; 61: 638-647
    • (2002) Kidney Int , vol.61 , pp. 638-647
    • Moe, S.1    O-Neill, K.2    Duan, D.3
  • 15
    • 0037835949 scopus 로고    scopus 로고
    • BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure
    • Davies MR, Lund RJ, Hruska KA. BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Neprol 2003; 14: 1559-1567
    • (2003) J Am Soc Neprol , vol.14 , pp. 1559-1567
    • Davies, M.R.1    Lund, R.J.2    Hruska, K.A.3
  • 16
    • 0942287106 scopus 로고    scopus 로고
    • Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model
    • Lund RJ, Davies MR, Brown AJ et al. Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model. J Am Soc Nephrol 2004; 15: 359-369
    • (2004) J Am Soc Nephrol , vol.15 , pp. 359-369
    • Lund, R.J.1    Davies, M.R.2    Brown, A.J.3
  • 17
    • 20844462829 scopus 로고    scopus 로고
    • Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome
    • Davies MR, Lund RJ, Mathew S et al. Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome. J Am Soc Nephrol 2005; 16: 917-928
    • (2005) J Am Soc Nephrol , vol.16 , pp. 917-928
    • Davies, M.R.1    Lund, R.J.2    Mathew, S.3
  • 18
    • 18244390222 scopus 로고    scopus 로고
    • Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals
    • Shao JS, Cheng SL, Pingsterhaus JM et al.Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest2005; 115: 1210-1220
    • (2005) J Clin Invest , vol.115 , pp. 1210-1220
    • Shao, J.S.1    Cheng, S.L.2    Pingsterhaus, J.M.3
  • 19
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
    • Rawadi G, Vayssiere B, Dunn F et al. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 2003; 18: 1842-1853
    • (2003) J Bone Miner Res , vol.18 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3
  • 20
    • 0037040197 scopus 로고    scopus 로고
    • Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2
    • Zebboudj AF, Imura M, Bostrom K.Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biol Chem 2002; 277: 4388-4394
    • (2002) J Biol Chem , vol.277 , pp. 4388-4394
    • Zebboudj, A.F.1    Imura, M.2    Bostrom, K.3
  • 21
    • 0036143995 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7: An anti-fibrotic morphogenetic protein with therapeutic importance in renal disease
    • Lund RJ, Davies MR, Hruska KA. Bone morphogenetic protein-7: an anti-fibrotic morphogenetic protein with therapeutic importance in renal disease. Curr Opin Nephrol Hypertens 2002; 11: 31-36
    • (2002) Curr Opin Nephrol Hypertens , vol.11 , pp. 31-36
    • Lund, R.J.1    Davies, M.R.2    Hruska, K.A.3
  • 22
    • 34547851691 scopus 로고    scopus 로고
    • Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis
    • Mezzano S, Droguett A, Burgos ME et al. Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis. Nephrol Dial Transplant 2007; 22: 1882-1890
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 1882-1890
    • Mezzano, S.1    Droguett, A.2    Burgos, M.E.3
  • 23
    • 39149086711 scopus 로고    scopus 로고
    • Co-regulation ofGremlin and Notch signalling in diabetic nephropathy
    • WalshDW, Roxburgh SA, McGettigan P et al. Co-regulation ofGremlin and Notch signalling in diabetic nephropathy. Biochim Biophys Acta 2008; 1782: 10-21
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 10-21
    • Walsh, D.W.1    Roxburgh, S.A.2    McGettigan, P.3
  • 24
    • 42949143822 scopus 로고    scopus 로고
    • Gremlin: A novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy
    • Carvajal G, Droguett A, Burgos ME et al. Gremlin: a novel mediator of epithelial mesenchymal transition and fibrosis in chronic allograft nephropathy. Transplant Proc 2008; 40: 734-739
    • (2008) Transplant Proc , vol.40 , pp. 734-739
    • Carvajal, G.1    Droguett, A.2    Burgos, M.E.3
  • 25
    • 39149099992 scopus 로고    scopus 로고
    • Gremlin promotes vascular smooth muscle cell proliferation and migration
    • Maciel TT, Melo RS, Schor N et al. Gremlin promotes vascular smooth muscle cell proliferation and migration. J Mol Cell Cardiol2008; 44: 370-379
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 370-379
    • Maciel, T.T.1    Melo, R.S.2    Schor, N.3
  • 26
    • 0036092160 scopus 로고    scopus 로고
    • How dietary phosphate, renal failure and calcitriol administration affect the serum calcium-phosphate relationship in the rat
    • Jara A, Chac'on C, Felsenfeld AJ. How dietary phosphate, renal failure and calcitriol administration affect the serum calcium-phosphate relationship in the rat. Nephrol Dial Transplant 2002; 17: 765-771
    • (2002) Nephrol Dial Transplant , vol.17 , pp. 765-771
    • Jara, A.1    Chac'on, C.2    Felsenfeld, A.J.3
  • 27
    • 33645458980 scopus 로고    scopus 로고
    • Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol
    • Lopez I, Aguilera-Tejero E, Mendoza FJ et al. Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol. J Am Soc Nephrol 2006; 17: 795-804
    • (2006) J Am Soc Nephrol , vol.17 , pp. 795-804
    • Lopez, I.1    Aguilera-Tejero, E.2    Mendoza, F.J.3
  • 28
    • 34347350171 scopus 로고    scopus 로고
    • Chronic kidney disease: Effects on the cardiovascular system
    • Schiffrin EL, Lipman ML, Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation 2007; 116: 85-97
    • (2007) Circulation , vol.116 , pp. 85-97
    • Schiffrin, E.L.1    Lipman, M.L.2    Mann, J.F.3
  • 29
    • 0032922119 scopus 로고    scopus 로고
    • Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney
    • Simon M, Maresh JG, Harris SE et al. Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney. Am J Physiol 1999; 276: F382-F389
    • (1999) Am J Physiol , vol.276
    • Simon, M.1    Maresh, J.G.2    Harris, S.E.3
  • 30
    • 33745911180 scopus 로고    scopus 로고
    • Function and effect of bone morphogenetic protein-7 in kidney bone and the bone and the bonevascular links in chronic kidney disease
    • Mathew S, Davies M, Lund G et al. Function and effect of bone morphogenetic protein-7 in kidney bone and the bone and the bonevascular links in chronic kidney disease. Eur J Clin Invest 2006; 36(Suppl 2): 43-50
    • (2006) Eur J Clin Invest , vol.36 , Issue.SUPPL. 2 , pp. 43-50
    • Mathew, S.1    Davies, M.2    Lund, G.3
  • 31
    • 4243180526 scopus 로고    scopus 로고
    • Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controllingmetanephric kidney and limb organogenesis
    • Michos O, Panman L, Vintersten K et al. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controllingmetanephric kidney and limb organogenesis. Development2004; 131: 3401-3410
    • (2004) Development , vol.131 , pp. 3401-3410
    • Michos, O.1    Panman, L.2    Vintersten, K.3
  • 32
    • 40949158527 scopus 로고    scopus 로고
    • BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells
    • Li X, Ying-Yang H, Giachelli CM. BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis 2008; 199: 271-277
    • (2008) Atherosclerosis , vol.199 , pp. 271-277
    • Li, X.1    Ying-Yang, H.2    Giachelli, C.M.3
  • 33
    • 0027285583 scopus 로고
    • Bone morphogenetic protein expression in human atherosclerotic lesions
    • Bostr̈om K, Watson KE, Horn S et al. Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest 1993; 91: 1800-1809
    • (1993) J Clin Invest , vol.91 , pp. 1800-1809
    • Bostr̈om, K.1    Watson, K.E.2    Horn, S.3
  • 34
    • 22744434737 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in vascular calcification
    • Hruska KA, Mathew S, Saab G. Bone morphogenetic proteins in vascular calcification. Circ Res 2005; 97: 105-114
    • (2005) Circ Res , vol.97 , pp. 105-114
    • Hruska, K.A.1    Mathew, S.2    Saab, G.3
  • 35
    • 0034074899 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro
    • Dorai H, Vukicevic S, Sampath TK. Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro. J Cell Physiol 2000; 184: 37-45
    • (2000) J Cell Physiol , vol.184 , pp. 37-45
    • Dorai, H.1    Vukicevic, S.2    Sampath, T.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.