Bone morphogenetic protein-7: An anti-fibrotic morphogenetic protein with therapeutic importance in renal disease

Current Opinion in Nephrology and Hypertension

Volumn 11, Issue 1, 2002, Pages 31-36

  Lund, Richard J ^a   Davies, Matthew R ^a   Hruska, Keith A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; OSTEOGENIC PROTEIN 1; STREPTOZOCIN;

BLOOD VESSEL CALCIFICATION; DIABETIC NEPHROPATHY; FIBROGENESIS; GLOMERULONEPHRITIS; HUMAN; KIDNEY DEVELOPMENT; KIDNEY DISEASE; KIDNEY FIBROSIS; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RENAL OSTEODYSTROPHY; REVIEW; SIGNAL TRANSDUCTION; UREMIA; URETER OBSTRUCTION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; FIBROSIS; KIDNEY; KIDNEY DISEASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036143995     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200201000-00005     Document Type: Review

References (27)

1. Bone morphogenetic proteins: From basic science to clinical applications
2. Role of morphogenetic proteins in skeletal tissue engineering and regeneration
3. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
4. Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart
5. Early embryonic lethality in Bmp5:Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
6. Expression pattern of osteogenic protein-1 (bone morphogenetic protein-7) in human and mouse development
7. BMP7 null mutation in mice: Developmental defects in skeleton, kidney, and eye
8. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
9. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
10. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos
11. Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney
12. Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys
13. Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat
14. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction
15. Loss of renal tubular BMP7 during the evolution of experimental diabetic nephropathy
16. Bone morphogenetic protein-7 (BMP-7): An effective therapy in diabetic nephropathy
17. Osteogenic protein-1 reduces glomerulonephritis and tubulointerstitial fibrosis associated with a mouse model for lupus nephritis
18. Pathophysiological mechanisms of vascular calcification in end-stage renal disease
19. Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro
20. A role for Smad6 in development and homeostasis of the cardiovascular system
21. Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice
22. BMP-7 is an effective treatment for vascular calcification in chronic kidney disease (CKD)
23. Interaction and functional cooperation of PEBP2/CBF with Smads
24. identification of an osteogenic protein-1 (bone morphogenetic protein-7)-responsive element in the promoter of the rat insulin-like growth factor-binding protein-5 gene
25. BMP-7 treatment maintains bone formation rates and eliminates marrow fibrosis in a murine model of high turnover renal osteodystrophy (ROD)
26. The 5′ flanking region of the human bone morphogenetic protein-7 gene
27. BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways