Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes

Journal of the American Chemical Society

Volumn 131, Issue 6, 2009, Pages 2313-2327

  Berry, Robert E ^a   Shokhirev, Maxim N ^a   Ho, Arthur Y W ^a   Yang, Fei ^a   Shokhireva, Tatiana K ^a   Zhang, Hongjun ^a   Weichsel, Andrzej ^a   Montfort, William R ^a   Ann Walker, F ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXIAL LIGAND; CARBOXYL GROUPS; HEME PROTEINS; LIGAND BINDING; MIDPOINT POTENTIALS; NANOMOLAR RANGE; NITROPHORIN; RELEASE FUNCTION; REVERSIBLE BINDING; SIDE-CHAIN; SOUTH AMERICA;

AMINES; AMINO ACIDS; BINDING SITES; HEMOGLOBIN; IRON COMPOUNDS; LIGANDS; ORGANIC ACIDS; PLANTS (BOTANY);

PORPHYRINS;

ALANINE; ASPARTIC ACID; FERRIC ION; FERROUS ION; GLUTAMIC ACID; HEMATIN; HEMOPROTEIN; HISTAMINE; IMIDAZOLE; NITROPHORIN 1; NITROPHORIN 2; NITROPHORIN 4; UNCLASSIFIED DRUG; HEME; IMIDAZOLE DERIVATIVE; LIGAND; NITRIC OXIDE; NITROPHORIN; SALIVA PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BLOOD; CARBOXY TERMINAL SEQUENCE; DILUTION; HUMAN; HUMAN TISSUE; LIGAND BINDING; MUTATION; NONHUMAN; PH; PRESERVATION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TRANSPORT; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; VASODILATATION; WOUND; CHEMICAL STRUCTURE; CHEMISTRY; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE; GENETICS; KINETICS; METABOLISM; THERMODYNAMICS;

ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; FERRIC COMPOUNDS; FERROUS COMPOUNDS; HEME; HEMEPROTEINS; HISTAMINE; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NITRIC OXIDE; SALIVARY PROTEINS AND PEPTIDES; THERMODYNAMICS;

EID: 65349191154     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja808105d     Document Type: Article

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