Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3471-3478

  Popowycz, Florence ^a   Schneider, Cédric ^a   DeBonis, Salvatore ^b   Skoufias, Dimitrios A ^b   Kozielski, Frank ^c   Galmarini, Carlos M ^d   Joseph, Benoît ^a  

^a UNIVERSITÉ LYON 1   (France)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d Univ Claude Bernard   (France)

Author keywords

Cancer; Myoseverin; Pyrazolo 1,5 a 1,3,5 triazine; Tubulin

Indexed keywords

4 (N METHYL N PHENYLAMINO) 2 METHYLSULFANYLPYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE; 4 (N METHYL N PHENYLAMINO) 2 METHYLSULFONYL)PYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE; 8 (1 METHYLETHYL) 4 (N METHYL N PHENYLAMINO) 2 (METHMETHYLSULFONYL)PYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE; 8 (1 METHYLETHYL) 4 (N METHYL N PHENYLAMINO) 2 (METHYLSULFANYL)PYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE; 8 BROMO 4 (N METHYL N PHENYLAMINO) 2 (METHYLSULFANYL)PYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE; 8 BROMO 4 (N METHYL N PHENYLAMINO) 2 (METHYLSULFONYL)PYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE; N2,N4 BIS (4 METHOXYBENZYL)PYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE 2,4 DIAMINE; N2,N4 BIS (4 METHOXYBENZYLAMINE) 8 (1 METHYLETHYL)-PYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE; PYRAZOLO[1,5 ALPHA] 1,3,5 TRIAZINE MYOSEVERIN DERIVATIVE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL CYCLE; CELL GROWTH; COLORECTAL CANCER; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY;

ANTINEOPLASTIC AGENTS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; MICROTUBULES; PURINES; PYRAZOLES; TRIAZINES; TUBULIN MODULATORS;

EID: 65349181832     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.007     Document Type: Article

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