Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2693-2698

  Jiang, Sheng ^a   Liao, Chenzhong ^b   Bindu, Lakshman ^c   Yin, Biaolin ^a   Worthy, Karen W ^c   Fisher, Robert J ^c   Burke Jr , Terrence R ^b   Nicklaus, Marc C ^b   Roller, Peter P ^b  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

Cyclic peptides; G1TE analogs; Grb2 SH2 antagonist; Grb2 SH2 domain; Phosphotyrosine

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; BRIDGED COMPOUND; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; PENTAPEPTIDE; PEPTIDOMIMETIC AGENT; PHOSPHOTYROSINE; PROTEIN SH2; RAS PROTEIN; SULFIDE;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR LIBRARY; MOLECULAR MODEL;

AMINO ACID SEQUENCE; COMPUTER SIMULATION; DRUG DISCOVERY; GRB2 ADAPTOR PROTEIN; PEPTIDE LIBRARY; PEPTIDES, CYCLIC; PROTEIN BINDING; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65349174618     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.134     Document Type: Article

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