3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents

Archiv der Pharmazie

Volumn 339, Issue 7, 2006, Pages 388-400

  De Luca, Laura ^a   Gitto, Rosaria ^a   Barreca, Maria Letizia ^a   Caruso, Roberta ^a   Quartarone, Silvana ^a   Citraro, Rita ^b   De Sarro, Giovambattista ^b   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

AMPA receptor; Anticonvulsant agents; HypoGen; Isoquinolines; Pharmacophore model

Indexed keywords

1 (3' NITROPHENYL) 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (4 FLUOROPHENYL) 6,7 DIMETHOXY 1,2 DIHYDROISOQUINOLINE 3(4H) ONE; 1 (4' FLUOROPHENYL) 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 (4' NITROPHENYL) 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 1 [1 (4' CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINYL]PROP 2 EN 1 ONE; 2 ACETYL 1 (3' NITROPHENYL) 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 1 (3' NITROPHENYL) 6,7 DIMETHOXY 1,2 DIHYDROISOQUINOLINE 3(4H) ONE; 2 ACETYL 1 (4 BROMOPHENYL) 6,7 DIMETHOXY 1,2 DIHYDROISOQUINOLINE 3(4H) ONE; 2 ACETYL 1 (4 CHLOROPHENYL) 6,7 DIMETHOXY 1,2 DIHYDROISOQUINOLINE 3(4H) ONE; 2 ACETYL 1 (4 FLUOROPHENYL) 6,7 DIMETHOXY 1,2 DIHYDROISOQUINOLINE 3(4H) ONE; 2 ACETYL 1 (4 NITROPHENYL) 6,7 DIMETHOXY 1,2 DIHYDROISOQUINOLINE 3(4H) ONE; 2 ACETYL 1 (4' BROMOPHENYL) 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 1 (4' CHLOROPHENYL) 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 1 (4' FLUOROPHENYL) 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 1 (4' NITROPHENYL) 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 6 METHOXY 1 PHENYL 1,2,3,4 TETRAHYDROISOQUINOLINE; AMPA RECEPTOR ANTAGONIST; ANTICONVULSIVE AGENT; ETHYL 1 (3' NITROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBOXYLATE; METHYL 1 (3' NITROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBOXYLATE; METHYL 1 (4' BROMOPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBOXYLATE; METHYL 1 (4' CHLOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBOXYLATE; METHYL 1 (4' FLUOROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBOXYLATE; METHYL 1 (4' NITROPHENYL) 6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 2 CARBOXYLATE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; CATALYST; CHEMICAL MODEL; CONTROLLED STUDY; CORRELATION COEFFICIENT; DOSE RESPONSE; DRUG EFFECT; FEMALE; HYDROGEN BOND; HYDROPHOBICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; BENZODIAZEPINES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; EPILEPSY, REFLEX; FEMALE; ISOQUINOLINES; MALE; MICE; MICE, INBRED DBA; MODELS, ANIMAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 33747031427     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200600022     Document Type: Article

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