The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist

Acta Crystallographica Section D: Biological Crystallography

Volumn 65, Issue 5, 2009, Pages 449-461

  Madauss, Kevin P ^a   Burkhart, William A ^a   Consler, Thomas G ^a   Cowan, David J ^a   Gottschalk, William K ^b   Miller, Aaron B ^a   Short, Steven A ^a   Tran, Thuy B ^c   Williams, Shawn P ^a  

^a GLAXOSMITHKLINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

ACC; ACC2; Acetyl CoA carboxylase; Fatty acid metabolism; Metabolic disorders

Indexed keywords

ACETYL COA CARBOXYLASE 2, HUMAN; ACETYL COENZYME A CARBOXYLASE; ACETYL-COA CARBOXYLASE 2, HUMAN; ACYLTRANSFERASE; AMINOGLYCOSIDE N1 ACETYLTRANSFERASE; AMINOGLYCOSIDE N1-ACETYLTRANSFERASE; FATTY ACID; HYBRID PROTEIN; LIGAND; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; COMPARATIVE STUDY; DRUG ANTAGONISM; FLUORESCENCE POLARIZATION; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ACETYL-COA CARBOXYLASE; ACETYLTRANSFERASES; AMINO ACID SEQUENCE; BINDING SITES; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; FATTY ACIDS; FLUORESCENCE POLARIZATION; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 65349164657     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444909008014     Document Type: Article

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