Novel immunoconjugates comprised of streptonigrin and 17-amino-geldanamycin attached via a dipeptide-p-aminobenzyl-amine linker system

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2650-2653

  Burke, Patrick J ^a   Toki, Brian E ^a   Meyer, David W ^a   Miyamoto, Jamie B ^a   Kissler, Kim M ^a   Anderson, Martha ^a   Senter, Peter D ^a   Jeffrey, Scott C ^a  

^a SEATTLE GENETICS INC   (United States)

Author keywords

Anti CD30; Anti CD70; Antibody drug conjugate; Antitumor; cAC10; Cancer; Cathepsin B; Conjugate; Cytotoxic; Geldanamycin; h1F6; Immunoconjugate; Self immolative spacer; Streptonigrin; Targeted delivery

Indexed keywords

17 VALYLALANINE 4 AMINOBENZYLGELDANAMYCIN; 17 VALYLALANINE 4 AMINOBENZYLGELDANAMYCIN MONOCLONAL ANTIBODY 1F6 CONJUGATE; 17 VALYLALANINE 4 AMINOBENZYLGELDANAMYCIN MONOCLONAL ANTIBODY CAC10 CONJUGATE; 4 AMINOBENZYLAMINE; ANTIBODY CONJUGATE; BENZYLAMINE DERIVATIVE; CYTOTOXIC AGENT; DIPEPTIDE; DISULFIDE; GELDANAMYCIN; MONOCLONAL ANTIBODY; RUFOCROMOMYCIN; STREPTONIGRIN MONOCLONAL ANTIBODY 1F6 CONJUGATE; STREPTONIGRIN MONOCLONAL ANTIBODY CAC10 CONJUGATE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CONTROLLED STUDY; CULTURE MEDIUM; DRUG SPECIFICITY; DRUG SYNTHESIS; DRUG TARGETING; HODGKIN DISEASE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; REACTION ANALYSIS; SINGLE DRUG DOSE; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD30; ANTIGENS, CD70; BENZOQUINONES; BENZYLAMINES; CELL LINE, TUMOR; DIPEPTIDES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMMUNOCONJUGATES; LACTAMS, MACROCYCLIC; MICE; STREPTONIGRIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 65349154663     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.145     Document Type: Article

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