Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides

FASEB Journal

Volumn 23, Issue 4, 2009, Pages 1230-1245

  Gao, Bin ^a   Sherman, Patrick ^b   Luo, Lan ^a   Bowie, John ^b   Zhu, Shunyi ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Gene cloning; Innate immunity; NMR structure; Venomous arthropod; Virus fusion domain

Indexed keywords

AMINO ACID; CATION; COMPLEMENTARY DNA; ISOLEUCYLPHENYLALANYLGLYCYLALANYLISOLEUCYLALANYLGLYCYLLEUCYLL EUCYLLYSYLASPARAGINYLISOLEUCYLPHENYLALANYL AMIDE; PHENYLALANYLPHENYLALANYLGLYCYLHISTIDYLLEUCYLPHENYLALANYLLY SYLLEUCYLALANYLTHREONYLLYSYLISOLEUCYLISOLEUCYLPROLYLSERYLLEUCYLPHENYL ALANYLGLUTAMINE; POLYPEPTIDE ANTIBIOTIC AGENT; TRIFLUOROETHANOL; UNCLASSIFIED DRUG; VENOM; VIRUS FUSION PROTEIN; ANTIMICROBIAL CATIONIC PEPTIDE; MEUCIN 13; MEUCIN 18; MEUCIN-13; MEUCIN-18; PEPTIDE; SCORPION VENOM; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTHROPOD; ARTICLE; BACTERIUM; CELL MEMBRANE; CIRCULAR DICHROISM; CLONE; CYTOLYSIS; CYTOSOL; DNA LIBRARY; DRUG POTENCY; ERYTHROCYTE; EUKARYOTE; EVOLUTION; FROG; FUNGUS; GENE DUPLICATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HYDROPHILICITY; HYDROPHOBICITY; INVERTEBRATE; MAST CELL; MESOBUTHUS EUPEUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PRECURSOR; PRIORITY JOURNAL; PROKARYOTE; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN STRUCTURE; RABBIT; RAT; SCORPION; SKIN; SPINAL GANGLION; VERTEBRATE; YEAST; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONSENSUS SEQUENCE; DRUG EFFECT; FACTUAL DATABASE; GENE LIBRARY; GENETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; MOLECULAR CLONING; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

ANURA; ARTHROPODA; EUKARYOTA; FUNGI; INVERTEBRATA; MESOBUTHUS EUPEUS; ORYCTOLAGUS CUNICULUS; PROKARYOTA; RATTUS; SCORPIONES; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BASE SEQUENCE; CIRCULAR DICHROISM; CLONING, MOLECULAR; CONSENSUS SEQUENCE; DATABASES, FACTUAL; DNA, COMPLEMENTARY; EVOLUTION, MOLECULAR; GENE LIBRARY; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HYDROPHOBICITY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SCORPION VENOMS; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 65349154518     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-122317     Document Type: Article

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