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1
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0035321067
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The evolution and genetics of innate immunity
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Kimbrell D.A., Beutler B. The evolution and genetics of innate immunity. Nat Rev Genet. 2:2001;256-267.
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(2001)
Nat Rev Genet
, vol.2
, pp. 256-267
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Kimbrell, D.A.1
Beutler, B.2
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2
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0035496012
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Cationic peptides: Effectors in innate immunity and novel antimicrobials
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Hancock R.E. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect Dis. 1:2001;156-164.
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(2001)
Lancet Infect Dis
, vol.1
, pp. 156-164
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Hancock, R.E.1
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3
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0037165196
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Antimicrobial peptides of multicellular organisms
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An insightful overview of the large body of research on antimicrobial peptides, provided by a pioneer and leading shaker of the field.
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Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 415:2002;389-395. An insightful overview of the large body of research on antimicrobial peptides, provided by a pioneer and leading shaker of the field.
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(2002)
Nature
, vol.415
, pp. 389-395
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Zasloff, M.1
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4
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0035951782
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Tigerinins: Novel antimicrobial peptides from the Indian frog Rana tigerina
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Sai K.P., Jagannadham M.V., Vairamani M., Raju N.P., Devi A.S., Nagaraj R., Sitaram N. Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. J Biol Chem. 276:2001;2701-2707.
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J Biol Chem
, vol.276
, pp. 2701-2707
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Sai, K.P.1
Jagannadham, M.V.2
Vairamani, M.3
Raju, N.P.4
Devi, A.S.5
Nagaraj, R.6
Sitaram, N.7
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5
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0036170116
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Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica
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Isaacson T., Soto A., Iwamuro S., Knoop F.C., Conlon J.M. Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica. Peptides. 23:2002;419-425.
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(2002)
Peptides
, vol.23
, pp. 419-425
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Isaacson, T.1
Soto, A.2
Iwamuro, S.3
Knoop, F.C.4
Conlon, J.M.5
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6
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0035183366
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Antimicrobial peptides from the skin of the Japanese mountain frog, Rana ornativentris
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Kim J.B., Iwamuro S., Knoop F.C., Conlon J.M. Antimicrobial peptides from the skin of the Japanese mountain frog, Rana ornativentris. J Pept Res. 58:2001;349-356.
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(2001)
J Pept Res
, vol.58
, pp. 349-356
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Kim, J.B.1
Iwamuro, S.2
Knoop, F.C.3
Conlon, J.M.4
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7
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0035815466
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A novel heterodimeric antimicrobial peptide from the tree-frog Phyllomedusa distincta
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Batista C.V.F., Scaloni A., Rigden D.J., Silva L.R., Romero A.R., Dukor R., Sebben A., Talamo F., Bloch C. A novel heterodimeric antimicrobial peptide from the tree-frog Phyllomedusa distincta. FEBS Lett. 494:2001;85-89.
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FEBS Lett
, vol.494
, pp. 85-89
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Batista, C.V.F.1
Scaloni, A.2
Rigden, D.J.3
Silva, L.R.4
Romero, A.R.5
Dukor, R.6
Sebben, A.7
Talamo, F.8
Bloch, C.9
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8
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0034939013
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Embryotoxicity of magainin-2-amide and its enhancement by cyclodextrin, albumin, hydrogen peroxide and acidification
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Mystkowska E.T., Niemierko A., Komar A., Sawicki W. Embryotoxicity of magainin-2-amide and its enhancement by cyclodextrin, albumin, hydrogen peroxide and acidification. Hum Reprod. 16:2001;1457-1463.
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Hum Reprod
, vol.16
, pp. 1457-1463
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Mystkowska, E.T.1
Niemierko, A.2
Komar, A.3
Sawicki, W.4
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9
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0035834573
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Pseudin-2: An antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog
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Olson L. III, Soto A.M., Knoop F.C., Conlon J.M. Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog. Biochem Biophys Res Commun. 288:2001;1001-1005.
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(2001)
Biochem Biophys Res Commun
, vol.288
, pp. 1001-1005
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Olson L. III1
Soto, A.M.2
Knoop, F.C.3
Conlon, J.M.4
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10
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0033962266
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Innate immunity and the normal microflora
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Boman H.G. Innate immunity and the normal microflora. Immunol Rev. 173:2000;5-16.
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Immunol Rev
, vol.173
, pp. 5-16
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Boman, H.G.1
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11
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0035975639
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Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin
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This work and those below from the same group are the first reports linking amphibian AMPs with host-protection from pathogens implicated in amphibian declines.
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Chinchar V.G., Wang J., Murti G., Carey C., Rollins-Smith L.A. Inactivation of frog virus 3 and channel catfish virus by esculentin-2P and ranatuerin-2P, two antimicrobial peptides isolated from frog skin. Virology. 288:2001;351-357. This work and those below from the same group are the first reports linking amphibian AMPs with host-protection from pathogens implicated in amphibian declines.
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(2001)
Virology
, vol.288
, pp. 351-357
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Chinchar, V.G.1
Wang, J.2
Murti, G.3
Carey, C.4
Rollins-Smith, L.A.5
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12
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0036027855
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Antimicrobial peptides defenses against pathogens associated with global amphibian declines
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Rollins-Smith L.A., Doersam J.K., Longcore J.E., Taylor S.K., Shamblin J.C., Carey C., Zasloff M.A. Antimicrobial peptides defenses against pathogens associated with global amphibian declines. Dev Comp Immunol. 26:2002;63-72.
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(2002)
Dev Comp Immunol
, vol.26
, pp. 63-72
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Rollins-Smith, L.A.1
Doersam, J.K.2
Longcore, J.E.3
Taylor, S.K.4
Shamblin, J.C.5
Carey, C.6
Zasloff, M.A.7
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13
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0036193198
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Activity of antimicrobial skin peptides from ranid frogs against Batrachochytrium dendrobatidis, the chytrid fungus associated with global amphibian declines
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Rollins-Smith L.A., Carey C., Longcore J., Doersam J.K., Boutte A., Bruzgal J.E., Conlon J.M. Activity of antimicrobial skin peptides from ranid frogs against Batrachochytrium dendrobatidis, the chytrid fungus associated with global amphibian declines. Dev Comp Immunol. 26:2002;471-479.
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(2002)
Dev Comp Immunol
, vol.26
, pp. 471-479
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Rollins-Smith, L.A.1
Carey, C.2
Longcore, J.3
Doersam, J.K.4
Boutte, A.5
Bruzgal, J.E.6
Conlon, J.M.7
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14
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0035810170
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Complex causes of amphibian population declines
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Kiesecker J.M., Blaustein A.R., Belden L.K. Complex causes of amphibian population declines. Nature. 410:2001;681-684.
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(2001)
Nature
, vol.410
, pp. 681-684
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Kiesecker, J.M.1
Blaustein, A.R.2
Belden, L.K.3
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15
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0034693283
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Induction of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli
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Matutte B., Storey K.B., Knoop F.C., Conlon J.M. Induction of synthesis of an antimicrobial peptide in the skin of the freeze-tolerant frog, Rana sylvatica, in response to environmental stimuli. FEBS Lett. 483:2000;135-138.
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(2000)
FEBS Lett
, vol.483
, pp. 135-138
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Matutte, B.1
Storey, K.B.2
Knoop, F.C.3
Conlon, J.M.4
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16
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0035380623
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The synthesis of antimicrobial peptides in the skin of Rana esculenta is stimulated by microorganisms
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The demonstration, provided by this paper, of the inducible expression of AMPs by exposition to components of the natural microflora is of particular interest.
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Mangoni M.L., Miele R., Renda T.G., Barra D., Simmaco M. The synthesis of antimicrobial peptides in the skin of Rana esculenta is stimulated by microorganisms. FASEB J. 15:2001;1431-1432. The demonstration, provided by this paper, of the inducible expression of AMPs by exposition to components of the natural microflora is of particular interest.
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(2001)
FASEB J
, vol.15
, pp. 1431-1432
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Mangoni, M.L.1
Miele, R.2
Renda, T.G.3
Barra, D.4
Simmaco, M.5
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17
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0034830455
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Involvement of Rel factors in the expression of antimicrobial peptide genes in amphibia
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Miele R., Björklund G., Barra D., Simmaco M., Engström Y. Involvement of Rel factors in the expression of antimicrobial peptide genes in amphibia. Eur J Biochem. 268:2001;443-449.
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(2001)
Eur J Biochem
, vol.268
, pp. 443-449
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Miele, R.1
Björklund, G.2
Barra, D.3
Simmaco, M.4
Engström, Y.5
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18
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0034840550
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Effects of temporins on molecular dynamics and membrane permeabilization in lipid vesicles
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Rinaldi A.C., Di Giulio A., Liberi M., Gualtieri G., Simmaco M., Barra D., Bozzi A. Effects of temporins on molecular dynamics and membrane permeabilization in lipid vesicles. J Pept Res. 58:2001;213-220.
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(2001)
J Pept Res
, vol.58
, pp. 213-220
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Rinaldi, A.C.1
Di Giulio, A.2
Liberi, M.3
Gualtieri, G.4
Simmaco, M.5
Barra, D.6
Bozzi, A.7
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19
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0037007001
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Interactions of the antimicrobial peptides temporins with model membranes. Comparison of Temporin B and Temporin L
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This is a detailed investigation of the modes of interaction of the short (13 amino acids) peptide temporins with model membranes. The authors measured the peptides' insertion into lipid monolayers, their influence on the structural dynamics of liposomal bilayers, and the impact on membrane topology of giant liposomes.
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Zhao H.X., Rinaldi A.C., Di Giulio A., Simmaco M., Kinnunen P.K.J. Interactions of the antimicrobial peptides temporins with model membranes. Comparison of Temporin B and Temporin L. Biochemistry. 41:2002;4425-4436. This is a detailed investigation of the modes of interaction of the short (13 amino acids) peptide temporins with model membranes. The authors measured the peptides' insertion into lipid monolayers, their influence on the structural dynamics of liposomal bilayers, and the impact on membrane topology of giant liposomes.
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(2002)
Biochemistry
, vol.41
, pp. 4425-4436
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Zhao, H.X.1
Rinaldi, A.C.2
Di Giulio, A.3
Simmaco, M.4
Kinnunen, P.K.J.5
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20
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0035941062
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The antimicrobial peptides lactoferricin B and magainin 2 cross over the bacterial cytoplasmic membrane and reside in the cytoplasm
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In this study, the authors detected magainin 2 and lactoferricin B, a peptide generated by gastric pepsin cleavage of bovine lactoferrin, in the cytoplasm of target bacterial species E. coli and S. aureus. The methodology used (localization of immunolabelled peptides by transmission electron microscopy) might be useful to examine if other AMPs have a cytoplasmic phase during their action.
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Haukland H.H., Ulvatne H., Sandvik K., Vorland L.H. The antimicrobial peptides lactoferricin B and magainin 2 cross over the bacterial cytoplasmic membrane and reside in the cytoplasm. FEBS Lett. 508:2001;389-393. In this study, the authors detected magainin 2 and lactoferricin B, a peptide generated by gastric pepsin cleavage of bovine lactoferrin, in the cytoplasm of target bacterial species E. coli and S. aureus. The methodology used (localization of immunolabelled peptides by transmission electron microscopy) might be useful to examine if other AMPs have a cytoplasmic phase during their action.
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(2001)
FEBS Lett
, vol.508
, pp. 389-393
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Haukland, H.H.1
Ulvatne, H.2
Sandvik, K.3
Vorland, L.H.4
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21
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0035967534
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The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: Implication to their mode of action
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Unger T., Oren Z., Shai Y. The effect of cyclization of magainin 2 and melittin analogues on structure, function, and model membrane interactions: implication to their mode of action. Biochemistry. 40:2001;6388-6397.
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(2001)
Biochemistry
, vol.40
, pp. 6388-6397
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Unger, T.1
Oren, Z.2
Shai, Y.3
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22
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0035115807
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Effects of peptide dimerization on pore formation: Antiparallel disulfide-dimerized magainin 2 analogue
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Hara T., Kodama H., Kondo M., Wakamatsu K., Takeda A., Tachi T., Matsuzaki K. Effects of peptide dimerization on pore formation: antiparallel disulfide-dimerized magainin 2 analogue. Biopolymers. 58:2001;437-446.
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(2001)
Biopolymers
, vol.58
, pp. 437-446
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Hara, T.1
Kodama, H.2
Kondo, M.3
Wakamatsu, K.4
Takeda, A.5
Tachi, T.6
Matsuzaki, K.7
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23
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0037053317
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Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives
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Kustanovich I., Shalev D.E., Mikhlin M., Gaidukov L., Mor A. Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives. J Biol Chem. 277:2002;16941-16951.
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(2002)
J Biol Chem
, vol.277
, pp. 16941-16951
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Kustanovich, I.1
Shalev, D.E.2
Mikhlin, M.3
Gaidukov, L.4
Mor, A.5
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24
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0037062560
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Structural consequences of carboxyamidation of dermaseptin S3
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Shalev D.E., Mor A., Kustanovich I. Structural consequences of carboxyamidation of dermaseptin S3. Biochemistry. 41:2002;7312-7317.
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(2002)
Biochemistry
, vol.41
, pp. 7312-7317
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Shalev, D.E.1
Mor, A.2
Kustanovich, I.3
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25
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0036174437
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Antibacterial properties of dermaseptin S4 derivatives with in vivo activity
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Navon-Venezia S., Feder R., Gaidukov L., Carmeli Y., Mor A. Antibacterial properties of dermaseptin S4 derivatives with in vivo activity. Antimicrob Agents Chemother. 46:2002;689-694.
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(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 689-694
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Navon-Venezia, S.1
Feder, R.2
Gaidukov, L.3
Carmeli, Y.4
Mor, A.5
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26
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0036207480
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In vitro antiplasmodium effects of dermaseptin S4 derivatives
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Dagan A., Efron L., Gaidukov L., Mor A., Ginsburg H. In vitro antiplasmodium effects of dermaseptin S4 derivatives. Antimicrob Agents Chemother. 46:2002;1059-1066.
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(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 1059-1066
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Dagan, A.1
Efron, L.2
Gaidukov, L.3
Mor, A.4
Ginsburg, H.5
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27
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0037025297
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Direct interaction of dermaseptin S4 aminoheptanoyl derivative with intraerythrocytic malaria parasite leading to increased specific antiparasitic activity in culture
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4-S4(1-13)a was singled out for its improved antiparasitic efficiency and reduced hemolysis. The new peptide was also shown to interact directly and intracellularly with the malaria parasite, whereas other derivatives acted causing the lysis of host RBCs.
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4-S4(1-13)a was singled out for its improved antiparasitic efficiency and reduced hemolysis. The new peptide was also shown to interact directly and intracellularly with the malaria parasite, whereas other derivatives acted causing the lysis of host RBCs.
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(2002)
J Biol Chem
, vol.277
, pp. 24067-24072
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Efron, L.1
Dagan, A.2
Gaidukov, L.3
Ginsburg, H.4
Mor, A.5
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28
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0036137074
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In vitro antiviral activity of dermaseptins against herpes simplex virus type 1
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Belaid A., Aouni M., Khelifa R., Trabelsi A., Jemmali M., Hani K. In vitro antiviral activity of dermaseptins against herpes simplex virus type 1. J Med Virol. 66:2002;229-234.
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(2002)
J Med Virol
, vol.66
, pp. 229-234
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Belaid, A.1
Aouni, M.2
Khelifa, R.3
Trabelsi, A.4
Jemmali, M.5
Hani, K.6
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29
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0035795730
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Analysis of antimicrobial peptide interactions with hybrid bilayer membrane systems using surface plasmon resonance
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Mozsolits H., Wirth H.-J., Werkmeister J., Aguilar M.-I. Analysis of antimicrobial peptide interactions with hybrid bilayer membrane systems using surface plasmon resonance. Biochim Biophys Acta. 1512:2001;64-76.
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(2001)
Biochim Biophys Acta
, vol.1512
, pp. 64-76
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Mozsolits, H.1
Wirth, H.-J.2
Werkmeister, J.3
Aguilar, M.-I.4
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30
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0034767060
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Comparison of the membrane association of two antimicrobial peptides, magainin 2 and indolicidin
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Zhao H.X., Mattila J.-P., Holopainen J.M., Kinnunen P.K.J. Comparison of the membrane association of two antimicrobial peptides, magainin 2 and indolicidin. Biophys J. 81:2001;2979-2991.
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(2001)
Biophys J
, vol.81
, pp. 2979-2991
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Zhao, H.X.1
Mattila, J.-P.2
Holopainen, J.M.3
Kinnunen, P.K.J.4
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31
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0037012964
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Magainin 2 in phospholipid bilayers: Peptide orientation and lipid chain ordering studied by X-ray diffraction
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Münster C., Spaar A., Bechinger B., Salditt T. Magainin 2 in phospholipid bilayers: peptide orientation and lipid chain ordering studied by X-ray diffraction. Biochim Biophys Acta. 1562:2002;37-44.
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(2002)
Biochim Biophys Acta
, vol.1562
, pp. 37-44
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Münster, C.1
Spaar, A.2
Bechinger, B.3
Salditt, T.4
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32
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0037092017
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Analysis of peptide rotational diffusion by homonuclear NMR
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Malliavin T.E., Giudice E. Analysis of peptide rotational diffusion by homonuclear NMR. Biopolymers. 63:2002;335-342.
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(2002)
Biopolymers
, vol.63
, pp. 335-342
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Malliavin, T.E.1
Giudice, E.2
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33
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0033814969
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Peptide-based antibiotics: A potential answer to raging antimicrobial resistance
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Mor A. Peptide-based antibiotics: a potential answer to raging antimicrobial resistance. Drug Dev Res. 50:2000;440-447.
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(2000)
Drug Dev Res
, vol.50
, pp. 440-447
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Mor, A.1
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34
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0034818366
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Affinity driven molecular transfer from erythrocyte membrane to target cells
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This paper describes a promising strategy for using RBCs as transport vesicles to deliver drugs to distant targets. The systems is based on the loading of RBCs with a nontoxic dermaseptin and the peptide's transfer to target bacteria, thanks to the greater affinity of the peptide for microbial membranes.
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Feder R., Nehushtai R., Mor A. Affinity driven molecular transfer from erythrocyte membrane to target cells. Peptides. 22:2001;1683-1690. This paper describes a promising strategy for using RBCs as transport vesicles to deliver drugs to distant targets. The systems is based on the loading of RBCs with a nontoxic dermaseptin and the peptide's transfer to target bacteria, thanks to the greater affinity of the peptide for microbial membranes.
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(2001)
Peptides
, vol.22
, pp. 1683-1690
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Feder, R.1
Nehushtai, R.2
Mor, A.3
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35
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0035077760
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Enhanced disease resistance conferred by expression of an antimicrobial magainin analog in transgenic tobacco
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This is the best example to date of successful expression of an amphibian AMP in a plant species, with resultant increased plant resistance to pathogens. For this study, the magainin analogue peptide Myp30 was chosen which was engineered to eliminate protease-sensitive sites, thus increasing the peptide's stability to extracellular plant proteases in vitro.
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Li Q., Lawrence C.B., Xing H.-Y., Babbitt R.A., Bass W.T., Maiti I.B., Everett N.P. Enhanced disease resistance conferred by expression of an antimicrobial magainin analog in transgenic tobacco. Planta. 212:2001;635-639. This is the best example to date of successful expression of an amphibian AMP in a plant species, with resultant increased plant resistance to pathogens. For this study, the magainin analogue peptide Myp30 was chosen which was engineered to eliminate protease-sensitive sites, thus increasing the peptide's stability to extracellular plant proteases in vitro.
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(2001)
Planta
, vol.212
, pp. 635-639
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Li, Q.1
Lawrence, C.B.2
Xing, H.-Y.3
Babbitt, R.A.4
Bass, W.T.5
Maiti, I.B.6
Everett, N.P.7
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36
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0036203523
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Enhanced resistance to the poplar fungal pathogen, Septoria musiva, in hybrid poplar clones transformed with genes encoding antimicrobial peptides
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Liang H.Y., Catranis C.M., Maynard C.A., Powell W.A. Enhanced resistance to the poplar fungal pathogen, Septoria musiva, in hybrid poplar clones transformed with genes encoding antimicrobial peptides. Biotechnol Lett. 24:2002;383-389.
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(2002)
Biotechnol Lett
, vol.24
, pp. 383-389
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Liang, H.Y.1
Catranis, C.M.2
Maynard, C.A.3
Powell, W.A.4
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37
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0035913957
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Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata
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Park S., Park S.H., Ahn H.C., Kim S., Kim S.S., Lee B.J. Structural study of novel antimicrobial peptides, nigrocins, isolated from Rana nigromaculata. FEBS Lett. 507:2001;95-100.
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(2001)
FEBS Lett
, vol.507
, pp. 95-100
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Park, S.1
Park, S.H.2
Ahn, H.C.3
Kim, S.4
Kim, S.S.5
Lee, B.J.6
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38
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0036166552
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Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
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Lai R., Zheng Y.T., Shen J.H., Liu G.J., Liu H., Lee W.H., Tang S.Z., Zhang Y. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. Peptides. 23:2002;427-435.
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(2002)
Peptides
, vol.23
, pp. 427-435
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Lai, R.1
Zheng, Y.T.2
Shen, J.H.3
Liu, G.J.4
Liu, H.5
Lee, W.H.6
Tang, S.Z.7
Zhang, Y.8
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39
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0035956269
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Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae)
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Ali M.F., Soto A., Knoop F.C., Conlon J.M. Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae). Biochim Biophys Acta. 1550:2001;81-89.
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(2001)
Biochim Biophys Acta
, vol.1550
, pp. 81-89
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Ali, M.F.1
Soto, A.2
Knoop, F.C.3
Conlon, J.M.4
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40
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0035984825
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Structure-function relationship studies on the frog skin antimicrobial peptide tigerinin 1: Design of analogs with improved activity and their action on clinical bacterial isolates
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Sitaram N., Sai K.P., Singh S., Sankaran K., Nagaraj R. Structure-function relationship studies on the frog skin antimicrobial peptide tigerinin 1: design of analogs with improved activity and their action on clinical bacterial isolates. Antimicrob Agents Chemother. 46:2002;2279-2283.
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(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 2279-2283
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Sitaram, N.1
Sai, K.P.2
Singh, S.3
Sankaran, K.4
Nagaraj, R.5
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42
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0037113168
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Temporin L: Antimicrobial, hemolytic, cytotoxic activities and effects on membrane permeabilization in lipid vesicles
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in press
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