Confocal Raman microspectroscopy on excised human skin: Uncertainties in depth profiling and mathematical correction applied to dermatological drug permeation

Journal of Biophotonics

Volumn 1, Issue 2, 2008, Pages 140-153

  Tfayli, A ^a   Piot, O ^a   Manfait, M ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Confocal Raman microspectroscopy; Drug tracking; Human skin; Mathematical modeling; Septh correction

Indexed keywords

CONFOCAL RAMAN MICROSPECTROSCOPY; DEPTH RESOLUTION; HUMAN SKIN; IN-DEPTH PROFILE; IN-DEPTH PROFILING; MATERIAL BOUNDARIES; MATHEMATICAL CORRECTIONS; THEORETICAL APPROACH;

MATHEMATICAL MODELS; REFRACTIVE INDEX;

DRUG PRODUCTS;

ANTIINFECTIVE AGENT; DERMATOLOGICAL AGENT; METRONIDAZOLE;

ARTICLE; BIOLOGICAL MODEL; DIFFUSION; HUMAN; IN VITRO STUDY; METABOLISM; METHODOLOGY; PERMEABILITY; RAMAN SPECTROMETRY; SKIN; SKIN ABSORPTION;

ANTI-INFECTIVE AGENTS; DERMATOLOGIC AGENTS; DIFFUSION; HUMANS; METRONIDAZOLE; MODELS, BIOLOGICAL; PERMEABILITY; SKIN; SKIN ABSORPTION; SPECTRUM ANALYSIS, RAMAN;

EID: 65349149361     PISSN: 1864063X     EISSN: 18640648     Source Type: Journal    
DOI: 10.1002/jbio.200710004     Document Type: Article

References (24)

1. P. J. Caspers, G. W. Lucassen, E. A. Carter, H. A. Bruining, and G. J. Puppels, In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles, J. Invest. Dermatol. 116, 434-442 (2001).
2. P. J. Caspers, G. W. Lucassen, and G. J. Puppels, Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin, Biophys. J. 85, 572- 580 (2003).
3. L. Chrit, C. Hadjur, S. Morel, G. Sockalingum, G. Lebourdon, F. Leroy, and M. Manfait, In vivo chemical investigation of human skin using a confocal Raman fiber optic microprobe, J. Biomed. Opt. 10, 44007 (2005).
4. A. Sieg, J. Crowther, P. Blenkiron, C. Marcott, and P. J. Matts, Confocal Raman microspectroscopy - Measuring the effects of topical moisturisers on stratum corneum water gradients in vivo. In: A. Mahadevan- Jansen and W. H. Petrich, editors; 2006. 6093, Bellingham, Washington, USA.
5. P. J. Caspers, A. C. Williams, E. A. Carter, H. G. Edwards, B. W. Barry, H. A. Bruining, and G. J. Puppels, Monitoring the penetration enhancer dimethyl sulfoxide in human stratum corneum in vivo by confocal Raman spectroscopy, Pharm. Res. 19, 1577-1580 (2002).
6. C. Xiao, C. R. Flach, C. Marcott, and R. Mendelsohn, Uncertainties in depth determination and comparison of multivariate with univariate analysis in confocal Raman studies of a laminated polymer and skin, Appl. Spectrosc. 58, 382-389 (2004).
7. C. Xiao, D. J. Moore, C. R Flach, and R. Mendelsohn, Permeation of dimyristoylphosphatidylcholine into skin - structural and spatial information from IR and Raman microscopic imaging, Vib. Spectrosc. 38, 151- 158 (2005).
8. C. Xiao, D. J. Moore, M. E. Rerek, C. R. Flach, and R. Mendelsohn, Feasibility of tracking phospholipid permeation into skin using infrared and Raman microscopic imaging, J. Invest. Dermatol. 124, 622-632 (2005).
9. A. Tfayli O. Piot F. Pitre, and M. Manfait, Follow-up of drug permeation through excised human skin with confocal Raman microspectroscopy, Eur. Biophys. J. (published online June 2007)
10. V. Wascotte, P. Caspers, J. de Sterke, M. Jadoul, R. H. Guy, and V. Preat, Assessment of the "skin reservoir" of urea by confocal Raman microspectroscopy and reverse iontophoresis in vivo, Pharm. Res. 24, 1897- 1901 (2007).
11. N. J. Everall, Confocal Raman microscopy: why the depth resolution and spatial accuracy can be much worse than you think, Appl. Spectrosc. 54, 1515-1520 (2000).
12. N. J. Everall, Modeling and measuring the effect of refraction on the depth resolution of confocal Raman microscopy, Appl. Spectrosc. 54, 773-782 (2000).
13. N. J. Everall, www.spectroscopyonline.com. Depth profiling with confocal Raman microscopy, Part II, Spectroscopy DOI, www.spectroscopyonline.com.
14. N. J. Everall, www.spectroscopyonline.com. Depth profiling with confocal Raman microscopy, Part I, Spectroscopy DOI, www.spectroscopyonline.com.
15. J. Vyorykka, J. Paaso, M. Tenhunen, J. Tenhunen, H. Iitti, T. Vuorinen, and P. Stenius, Analysis of depth profiling data obtained by confocal Raman microspectroscopy, Appl. Spectrosc. 57, 1123-1128 (2003).
16. K. J. Baldwin and D. N. Batchelder, Confocal Raman microspectroscopy through a planar interface, Appl. Spectrosc. 55, 517-524(518) (2001).
17. J. L. Bruneel, J. C. Lassegues, and C. Sourisseau, Indepth analyses by confocal Raman microspectrometry: experimental features and modeling of the refraction effects, J. Raman. Spectrosc. 33, 815-828 (2002).
18. J. L. Bruneel, J. C. Lassegues, and C. Sourisseau, Aspects expérimentaux concernant les analyses en profondeur en microspectromé trie. Abstract book Journées Raman 2001, December 6-7, 2001, Montpellier (France); 9-11.
19. P. Torok, P. Varga, and G. R. Booker, Electromagnetic diffraction of light focused through a planar interface between materials of mismatched refractive indices: structure of the electromagnetic field, I J. Opt. Soc. Am. A 12, 2136-2144 (1995).
20. P. Torok, P. Varga, A. Konkol, and G. R. Booker, Electromagnetic diffraction of light focused through a planar interface between materials of mismatched refractive indices: structure of the electromagnetic field, II J. Opt. Soc. Am. A 13, 2332-2338 (1996).
21. P. Torok, P. Varga, Z. Laczik, and G. R. Booker, Electromagnetic diffraction of light focused through a planar interface between materials of mismatched refractive indices: an integral representation, J. Opt. Soc. Am. A 12, 325-332 (1995).
22. Parker-TexLoc, http://www.texloc.com/closet/cl_refractiveindex.html, in, Parker-TexLoc.
23. A. Knuttel and M. Boehlau-Godau, Spatially confined and temporally resolved refractive index and scattering evaluation in human skin performed with optical coherence tomography, J. Biomed. Opt. 5, 83- 92 (2000).
24. Galderma, http://www.galderma.com/, in Galderma Laboratories.