Analysis of genetic mutations associated with anti-malarial drug resistance in Plasmodium falciparum from the Democratic Republic of East Timor

Malaria Journal

Volumn 8, Issue 1, 2009, Pages

  De Almeida, Afonso ^a,b   Arez, Ana Paula ^b   Cravo, Pedro Vl ^b   Do Rosário, Virgílio E ^b  

^a Universidade Nacional de Timor Leste   (Portugal)

^b INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; FANSIDAR; PROTEIN PFCRT; PROTEIN PFDHFR; PROTEIN PFDHPS; PROTEIN PFMDR1; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT;

ADULT; ANTIBIOTIC RESISTANCE; ARTICLE; CODON; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; TIMOR-LESTE; ADOLESCENT; ALLELE; ANIMAL; CHILD; DRUG EFFECT; DRUG RESISTANCE; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; MUTATION; PARASITOLOGY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADOLESCENT; ADULT; ALLELES; ANIMALS; ANTIMALARIALS; CHILD; CHLOROQUINE; DRUG RESISTANCE; EAST TIMOR; FEMALE; GENOTYPE; HUMANS; MALARIA, FALCIPARUM; MALE; MUTATION; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTOZOAN PROTEINS; YOUNG ADULT;

EID: 65349097898     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-8-59     Document Type: Article

References (35)

1. WHO, Advances in malaria chemotherapy. WHO Technical Reports World Health Organ Geneva 1984 711
2. History and importance antimalarial drug resistance. U D'Alessandro H Buttiens, Trop Med Int Health 2001 6 845 848 10.1046/j.1365-3156.2001.00819.x 11703837 (Pubitemid 33010869)
3. Malaria Control in Complex Emergencies: the example of East Timor. J Kolaczinski J Webstar, Trop Med Int Health 2003 8 48 55 10.1046/j.1365-3156. 2003.00969.x 12535250 (Pubitemid 36151578)
4. Growing plains of East Timor: health of an infant nation. K Morris, The Lancet 2001 357 873 877 10.1016/S0140-6736(00)04203-3 (Pubitemid 32239394)
5. Malaria Epidemiological Profile- East and West Timor. PR Arbani G Petersen, World Health Organ Geneva 1999
6. East Timor Health Sector Situation report. A Andjaparidze SK Marwah C Debnath, World Health Organ East Timor 2000
7. Malaria Consortium, RBM Complex Emergency Malaria Data Base East Timor. J Webster, World Organ Health Geneva 2000
8. Efficacy of cloroquine in the treatment of uncomplicated Plasmodium falciparum infection in East Timor, 2000. N Ezard M Burns C Lynch Q Cheng MD Edstein, Acta Trop 2003 88 87 90 10.1016/S0001-706X(03)00161-X 12943982 (Pubitemid 37013341)
9. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. MB Reed KJ Saliba SR Caruana K Kirk AF Cowman, Nature 2000 403 906 909 10.1038/35002615 10706290 (Pubitemid 30130994)
10. A molecular marker for surveillance of chloroquine-resistant falciparum malaria. A Djimde OK Doumbo JF Cortese K Kayentao S Doumbo Y Diourte A Dicko XZ Su T Nomura DA Fidock, NEJM 2001 344 257 263 10.1056/NEJM200101253440403 11172152 (Pubitemid 32108530)
11. Mutations in dihydropteroate synthase are responsible for sulfone and sufonamide resistance in Plasmodium falciparum. T Triglia JGT Menting C Wilson AF Cowman, Proc Natl Acad Sci USA 1997 94 13944 13949 9391132 10.1073/pnas.94.25.13944 (Pubitemid 28009689)
12. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. AF Cowman MJ Morry BA Biggs GA Cross SJ Foote, Proc Natl Acad Sci USA 1988 85 9109 9113 3057499 10.1073/pnas.85.23.9109 (Pubitemid 19001849)
13. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. DS Peterson D Walliker TE Wellems, Proc Natl Acad Sci USA 1988 85 9114 9118 2904149 10.1073/pnas.85.23.9114 (Pubitemid 19001850)
14. Allelicexchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. T Triglia P Wang PF Sims JE Hyde AF Cowman, EMBO J 1998 17 3807 3815 9669998 10.1093/emboj/17.14.3807 (Pubitemid 28333967)
15. Efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated P. falciparum malaria in East Timor. M Burns Baker Joanne MA Alyson G Michellel DE Michael Q Cheng, Am J Trop Med Hyg 2006 74 361 366 16525092 (Pubitemid 46774355)
16. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections. G Snounou, Mol Biochem Parasitol 1993 58 283 292 10.1016/0166-6851(93)90050-8 8479452 (Pubitemid 23076417)
17. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. G Snounou S Viriyakosol XP Zhu W Jarra L Pinheiro VE Rosário S Thaithong KN Brown, Mol Biochem Parasitol 1993 1 315 320 10.1016/0166-6851(93)90077-B (Pubitemid 23313412)
18. Plasmodium falciparum: Detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. MT Duraisingh J Curtis DC Warhurst, Exp Parasitol 1998 89 1 8 10.1006/expr.1998.4274 9603482 (Pubitemid 28377366)
19. Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand. D Lopes K Rungsihirunrat F Noqueira A Seugorn JP Gil VE do Rosário P Cravo, Malar J 2002 1 1 11 12057021 10.1186/1475-2875-1-12 (Pubitemid 38957429)
20. Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. JG Kublin JF Cortese EM Njunju RA Mukadam JJ Wirima PN Kazembe AA Djimde B Kouriba TE Taylor CV Plowe, J Infect Dis 2003 187 1870 5 10.1086/375419 12792863 (Pubitemid 36724485)
21. Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of choroquine use against P. falciparum malaria in Hainan, people's Republic of China. X Wang J Um Q Li P Chen X Guo L Fu L Chen X Su TE Wellems, Am J Trop Med Hyg 2005 72 410 414 15827277 (Pubitemid 41278849)
22. Amodiaquine resistant Plasmodium falciparum malaria in vivo is associated with selection of Pfcrt 76T and Pfmdr1 86Y. G Holmgren GP Gil PM Ferreira MI Veiga CO Obonyo A Bjorkman, Infect Genet Evol 2006 6 309 314 10.1016/j.meegid.2005.09.001 16271310 (Pubitemid 43785813)
23. Association between mutation in Plsamodium falciparum chloroquine resistance transport and Plsamodium falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in Plsamodium falciparum malaria-infected children in Nigeria. CT Happi GO Gbotosho OA Folarin OM Bolaji A Sowunmi DE Kyle W Milhous DF Wirth AMJ Oduola, Am J Trop Med Hyg 2006 75 155 161 16837724
24. Monitoring antimalarial drug resistance: making the most of the tools at hand. CV Plowe, J Exp Biol 2003 206 3745 3752 10.1242/jeb.00658 14506209 (Pubitemid 37365456)
25. Pfmdr 1 alleles and response to ultralow-dose mefloquine treatment in Gabonese patients. DP Mawili-Mboumba JFJ Kun B Lell PG Kremsner F Ntoumi, Antimicrob Agents Chemother 2002 46 166 170 11751128 10.1128/AAC.46.1.166-170. 2002 (Pubitemid 34031619)
26. Frequency distribution on antimalarial drug-resistant alleles among isolates of P. falciparum in Purworejo District, Central Java Province, Indonesia. D Syarfruddin PBS Asih SL Aggarwal AH Shankar, Am J Trop Med Hyg 2003 69 614 620 14740877 (Pubitemid 38248232)
27. Point mutations in the dihydrofolate reductase thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum. LK Basco P Eldin de Pécoulas CM Wilson JL Bras A Mazabraud, Mol Biochem Parasitol 1995 69 135 138 10.1016/0166-6851(94)00207-4 7723784
28. Mutations in Plasmodium falciparum difydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. CV Plowe JF Cortese A Djimde OC Nwanyanwu WM Watkins PA Winstanley JGE Franco RE Mollinedo JC Avila JL Cespedes D Carter OK Doumbo, J Infect Dis 1997 176 1590 1596 9395372 (Pubitemid 27518161)
29. Point mutations in dihydrofolate reductase and dihydopteroate synthase genes of Plasmodium falciparum isolates from Venezuela. L Urdaneta C Plowe I Goldman AA Lal, Am J Trop Med Hyg 1999 61 457 462 10497990 (Pubitemid 29428720)
30. Resistance to antiolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. P Wang CS Lee R Bayoumi A Djimde O Doumbo G Swedberg LD Dao H Mshinda M Tanner WM Watkins PFG Sims JE Hyde, Mol Biochem Parasitol 1997 89 161 177 10.1016/S0166-6851(97)00114-X 9364963 (Pubitemid 27435090)
31. Analysis Pfcrt, Pfmdr1, dhfr, and dhps mutations and drugs sensitivities in P. falciparum isolates from patients in Vietnam before and after treatment with artemisinin. Thanh Ngo M Durasingh Michael Reed D Hipgrave B Biggs AF Cowman, Am Soc Trop Med Hyg 2003 68 350 356 (Pubitemid 38240527)
32. Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in P. falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites. AM Nzila EK Mberu J Sulo H Dayo PA Winstanley CH Sibley WM Watkins, Am Soc Microbiol 2000 44 991 996 (Pubitemid 30165281)
33. Plasmodium falciparum resistance to sulfadoxyne/pyrimethamine in Uganda: correlation with polymorphisms in the dehidrofolate reductase and dihydropterate synthetase genes. T Jelinek AHD Kilian G Kabagambe FV Sonnenberg, Am J Trop Med Hyg 1999 61 463 466 10497991 (Pubitemid 29428721)
34. Molecular epidemiology of Plasmodium falciparum resistance to antimalarial drugs in Indonesia. D Syarfruddin PBS Asih GJ Casey J Maguire JK Baird HS Nagesha AF Cowman JC Reeder, Am J Trop Med Hyg 2005 72 174 181 15741554 (Pubitemid 41278902)
35. Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-years olds in Brazzaville, Congo. M Ndounga R Tahar LK Basco PN Casimiro DA Malonga F Ntoumi, Trop Med Int Health 2007 12 1164 1171 17956498 (Pubitemid 47621998)