A cattle heart protein hydrolysate ameliorates hypercholesterolemia accompanied by suppression of the cholesterol absorption in Rats and Caco-2 cells

Bioscience, Biotechnology and Biochemistry

Volumn 73, Issue 3, 2009, Pages 607-612

  Nakade, Koji ^a   Kaneko, Hideki ^b   Oka, Takao ^b   Ahhmed, Abdulatef M ^c   Muguruma, Michio ^c   Numata, Masahiro ^a   Nagaoka, Satoshi ^b  

^a Itoham Foods Inc   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

Caco 2 cells; Cattle heart; Cholesterol; Livestock by product; Peptide

Indexed keywords

CACO-2 CELLS; CATTLE HEART; CHOLESTEROL ABSORPTIONS; HYPERCHOLESTEROLEMIA; HYPOCHOLESTEROLEMIC ACTIVITIES; IN-VITRO; IN-VIVO; LIVESTOCK BY-PRODUCT; PROTEIN HYDROLYSATES; SERUM CHOLESTEROLS;

ABSORPTION; AGRICULTURE; AMINES; CASEIN; FEEDING; HYDROLYSIS; MICELLES; POLARIZATION; RATS;

CHOLESTEROL;

CASEIN; CHOLESTEROL; MUSCLE PROTEIN; PEPTIDE FRAGMENT; PROTEIN HYDROLYSATE;

ABSORPTION; ANIMAL; ARTICLE; CATTLE; CELL STRAIN CACO 2; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; HEART MUSCLE; HUMAN; HYPERCHOLESTEROLEMIA; MALE; METABOLISM; MICELLE; PROTEIN INTAKE; RAT; SOLUBILITY; ULTRAFILTRATION;

ABSORPTION; ANIMALS; CACO-2 CELLS; CASEINS; CATTLE; CHOLESTEROL; DIETARY PROTEINS; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MICELLES; MUSCLE PROTEINS; MYOCARDIUM; PEPTIDE FRAGMENTS; PROTEIN HYDROLYSATES; RATS; SOLUBILITY; ULTRAFILTRATION;

BOS; RATTUS;

EID: 65349095559     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80687     Document Type: Article

References (31)

1. Carrol, K. K., and Hamilton, R. M. G., Effects of dietary protein and carbohydrate on plasma cholesterol levels in relation to atherosclerosis. J. Food Sci., 40, 18-23 (1975).
2. Potter, S. M., Overview of proposed mechanisms for the hypocholesterolemic effect of soy. J. Nutr., 125, 606S-611S (1995).
3. Sirtori, C. R., Even, R., and Lovati, M. S., Soybean protein diet and plasma cholesterol: from therapy to molecular mechanisms. Ann. NYAcad. Sci., 676, 188-201 (1993).
4. Zhang, X., and Beynen, A. C, Influence of dietary fish proteins on plasma and liver cholesterol concentrations in rats. Br. J. Nutr., 69, 767-777 (1993).
5. Nagaoka, S., Kanamaru, Y., and Kuzuya, Y., Effects of whey protein and casein on the plasma and liver lipids in rats. Biosci. Biotechnol. Biochem., 55, 813-818 (1991).
6. Nagaoka, S., Futamura, Y., Miwa, K., Awano, T., Yamauchi, K., Kanamaru, Y., Kojima, T., and Kuwata, T., Identification of novel hypocholesterolemic peptides derived from bovine milk ß-lactoglobulin. Biochem. Biophys. Res. Commun., 281, 11-17 (2001).
7. Nagaoka, S., Masaoka, M., Zhang, Q., Hasegawa, M., and Watanabe, K., Egg ovomucin attenuates hypercholesterolemia in rats and inhibits cholesterol absorption in Caco-2 cells. Lipids, 37, 267-272 (2002).
8. Asato, L., Wang, M., Chan, Y. C, Yeh, S. H., Chung, H. M., Chung, S. Y., Chida, S., Uezato, T., Suzuki, I., Yamagata, N., Kokubu, T., and Yamamoto, S., Effects of egg white on serum cholesterol concentration in young women. J. Nutr. Sci. Vitaminol., 42, 87-96 (1996).
9. Anderson, B. A., Composition and nutritional value of edible meat by-products. In "Edible Meat By-Products, Advances in Meat Research Vol. 5," eds. Pearson, A. M., and Dutson, T. R., Elsevier Applied Science, London, pp. 15-45 (1988).
10. Briggs, G. M., and Schweigert, B. S., An overview of meat in the diet. In "Meat and Health, Advances in Meat Research Vol. 6," eds. Pearson, A. M., and Dutson, T. R., Elsevier Applied Science, London, pp. 1-20 (1990).
11. Thomas, M., Leelamma, S., and Kurup, P. A., Effects of dietary protein on cholesterol lowering action of blackgram fiber. Indian J. Biochem. Biophys., 23, 179-181 (1986).
12. Critchfield, J. W., Schneeman, B., and Rucker, R., Protein quality: serum cholesterol and apolipoprotein concentrations in the rat. Nutr. Res., 10, 655-662 (1990).
13. Johnson, J. A., Beitz, D. C, and Jacobson, N. L., Effects of dietary beef and soy protein on tissue composition and low density lipoprotein uptake in young pigs. J. Nutr., 119, 696-705 (1989).
14. Morimatsu, F., Ito, M., Budijanto, S., Watanabe, I., Furukawa, Y., and Kimura, S., Plasma cholesterol-suppressing effect of papain-hydrolyzed pork meat in rats fed hypercholesterolemic diet. J. Nutr. Sci. Vitaminol, 42, 145-153 (1996).
15. quot;Official Methods of Analysis" 14th ed., Association of Official Analytical Chemists International, Arlington, pp. 152-169 (1984).
16. Folch, J., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226, 497-509 (1957).
17. Nagaoka, S., Miwa, K., Eto, M., Kuzuya, Y., Hori, G., and Yamamoto, K., Soyprotein peptic hydrolyzate with bound phospholipids decreases micellar solubility and cholesterol absorption in rats and Caco-2 cells. J. Nutr., 129, 1725-1730 (1999).
18. Nagaoka, S., Awano, T., Nagata, N., Masaoka, M., Hori, G., and Hashimoto, K., Serum cholesterol reduction and cholesterol absorption inhibition in Caco-2 cells by soyprotein peptic hydrolyzate. Biosci. Biotechnol. Biochem., 61, 354-356 (1997).
19. American Institute of Nutrition, Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J. Nutr, 107, 1340-1348 (1997).
20. Snedecor, G. W., and Cochran, W. G., "Statistical Methods" 6th ed., The Iowa State University Press, Ames (Japanese edition: Iwanami Pub. Inc., Tokyo) (1967).
21. Huff, M. W., and Carroll, K. K., Effects of dietary proteins and amino acid mixtures on plasma cholesterol levels in rabbits. J. Nutr., 110, 1676-1685 (1980).
22. Jacques, H., Deshaies, Y., and Savoie, L., Relationship between dietary proteins, their in vitro digestion products, and serum cholesterol in rats. Atherosclerosis, 61, 89-98 (1986).
23. Sugiyama, K., Ohkawa, S., and Muramatsu, K., Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet. J. Nutr. Sci. VitaminoL, 32, 413-423 (1986).
24. Nagata, Y., Ishiwaki, N., and Sugano, M., Studies on the mechanisms of antihypercholesterolemic action of soy protein and soy protein-type amino acid mixtures in relation to the casein counterparts in rats. J. Nutr., 112, 1614-1625 (1982).
25. Nagaoka, S., Shimizu, K., Kaneko, H., Shibayama, F., Morikawa, K., Kanamaru, Y., Otsuka, A., Hirahashi, T., and Kato, T., A novel protein c-phycocyanin plays a crucial role in the hypocholesterolemic action of spirulina platensis concentrate in rats. J. Nutr., 135, 2425-2430 (2005).
26. Wilson, M. D., and Rudel, L. L., Review of cholesterol absorption with emphasis on dietary and biliary cholesterol. J. Lipid Res., 35, 943-955 (1994).
27. Ikeda, I., Tanaka, K., Sugano, M., Vahouny, G. V., and Gallo, L. L., Inhibition of cholesterol absorption in rats by plant sterols. J. Lipid Res., 29, 1573-1582 (1988).
28. Hirose, N., Inoue, T., Nishihara, K., Sugano, M., Akimoto, K., Shimizu, S., and Yamada, H., Inhibition of cholesterol absorption and synthesis in rats by sesamin. J. Lipid Res., 32, 629-638 (1991).
29. Ikeda, I., Imasato, Y., Sasaki, E., Nakayama, M., Nagao, H., Takeo, T., Yayabe, F., and Sugano, M., Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats. Biochim. Biophys. Acta, 1127, 141-146 (1992).
30. Field, F. J., Albright, E., and Mathur, S. N., Regulation of cholesterol esterification by micellar cholesterol in Caco-2 cells. J. Lipid Res., 28, 1057-1066 (1987).
31. Hughes, T. E., Sasak, W. V., Ordovas, J. M., Forte, T. M. S., and Schaefer, E. J., A novel cell line (Caco-2) for the study of intestinal lipoprotein synthesis. J. Biol. Chem., 262, 3762-3767 (1987).