Straightforward and highly efficient catalyst-free one-step synthesis of 2-(purin-6-yl)acetoacetic acid ethyl esters, (purin-6-yl)acetates, and 6-methylpurines through SNAr-based reactions of 6-halopurines with ethyl acetoacetate

Organic Letters

Volumn 11, Issue 8, 2009, Pages 1745-1748

  Quy, Gui Rong ^a   Mao, Zhi Jie ^a   Niuy, Hong Ying ^b   Wang, Dong Chao ^a   Xia, Chao ^a   Guo, Hai Ming ^a  

^a HENAN NORMAL UNIVERSITY   (China)

^b HENAN INSTITUTE OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOACETIC ACID DERIVATIVE; ACETOACETIC ACID ETHYL ESTER; ESTER; HALOGENATED HYDROCARBON; PURINE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; SYNTHESIS;

ACETOACETATES; COMBINATORIAL CHEMISTRY TECHNIQUES; ESTERS; HYDROCARBONS, HALOGENATED; MOLECULAR STRUCTURE; PURINES;

EID: 65249184563     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol9002256     Document Type: Article

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61. 4 and the solvent was evaporated in vacuo. The residue was purified by silica gel chromatography (petroleum ether/ethyl acetate) to give the desired products 3a, 4a, and 5a, respectively.