5-Hydroxytryptophan acts on the mitogen-activated protein kinase extracellular-signal regulated protein kinase pathway to modulate cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 cells

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 4, 2009, Pages 553-557

  Chae, Hee Sung ^a   Kang, Ok Hwa ^a   Choi, Jang Gi ^a   Oh, You Chang ^a   Lee, Young Seob ^a   Jang, Hye Jin ^a   Kim, Jong Hak ^a   Park, Hyun ^a,b   Jung, Kyu Yong ^b   Sohn, Dong Hwan ^a   Kwon, Dong Yeul ^a  

^a Wonkwang University   (South Korea)

^b Wonkwang University School of Medicine   (South Korea)

Author keywords

5 hydroxytryptophan; Cyclooxygenase 2; Inducible nitric oxide synthase

Indexed keywords

5 HYDROXYTRYPTOPHAN; ACETIC ACID; ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WRITHING TEST;

5-HYDROXYTRYPTOPHAN; ANALGESICS, NON-NARCOTIC; ANIMALS; BLOTTING, WESTERN; CYCLOOXYGENASE 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-6; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PAIN MEASUREMENT; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THIAZOLES;

EID: 65249180682     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.553     Document Type: Article

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