Serum leptin levels after central and systemic injection of a serotonin precursor, 5-hydroxytryptophan, in mice

European Journal of Pharmacology

Volumn 406, Issue 1, 2000, Pages 159-162

  Yamada, Jun ^a   Ujikawa, Masanori ^a   Sugimoto, Yumi ^a  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); 5 HTP (5 Hydroxytryptophan); Benserazide; Leptin; Mouse

Indexed keywords

5 HYDROXYTRYPTOPHAN; BENSERAZIDE; LEPTIN; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

5-HYDROXYTRYPTOPHAN; ANIMALS; BENSERAZIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; MICE; SEROTONIN; SEROTONIN AGENTS; TIME FACTORS;

EID: 0034613398     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00624-5     Document Type: Article

References (19)

1. Auwerx J., Staels B. Leptin. Lancet. 351:1998;737-742.
2. Bernardis L.L., Bellinger L.L. The lateral hypothalamic area revisited: ingestive behavior. Neurosci. Biobehav. Rev. 20:1996;189-287.
3. Blundell J.E., Latham C.J. Serotonergic influences on food intake: effects of 5-hydroxytryptophan on parameters of feeding in deprived and free-feeding rats. Pharmacol. Biochem. Behav. 11:1979;431-437.
4. Campfield M.A., Smith F.J., Gulsez Y., Devos R., Burn P. Mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
5. Curzon G. Serotonin and appetite. Ann. N. Y. Acad. Sci. 600:1990;521-531.
6. Dourish C.T. Multiple serotonin receptors: opportunities for new treatments for obesity? Obes. Res. 3:1995;449S-462S.
7. Dryden S., Brown M., King P., Williams G. Decreased plasma leptin levels in lean and obese Zucker rats after treatment with the serotonin reuptake inhibitors fluoxetine. Horm. Metab. Res. 31:1999;363-366.
8. Everett G.M. Effects of 5-hydroxytryptophan on brain levels of dopamine, norepinephrine and serotonin in mice. Adv. Biochem. Psychopharmacol. 10:1974;261-262.
9. Flier J.S. Leptin expression and action: new experimental paradigms. Proc. Natl. Acad. Sci. U. S. A. 94:1997;4242-4245.
10. Fruhbeck G., Jebb S.A., Prentice A.M. Leptin: physiology and pathophysiology. Clin. Physiol. 18:1998;399-419.
11. Haley T.J., McCormick W.G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. J. Pharmacol. 12:1957;12-15.
12. Hyttel J., Fjalland B. Central 5-HT decarboxylase inhibiting properties of Ro 4-4602 in relation to 5-HTP potentiation in mice. Eur. J. Pharmacol. 19:1972;112-114.
13. Krstic M.K., Djurkovic D. Comparison of the cardiovascular responses to intracerebroventricular administration of tryptamine, 5-hydroxytryptamine, tryptophan and 5-hydroxytryptophan in rats. Arch. Int. Physiol. Biochim. 89:1981;385-391.
14. Pellymounter M.A., Cullen M.J., Baker M.B.R.H., Winters D., Boone T., Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:1995;540-543.
15. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98:1996;1101-1106.
16. Simansky K.J. Serotonergic control of the organization of feeding and satiety. Behav. Brain Res. 73:1996;37-42.
17. 3 receptor agonists on food intake in food-deprived and 2-deoxy-D-glucose-treated rats. Eur. J. Pharmacol. 316:1996;15-21.
18. Yamada J., Sugimoto Y., Wakita H., Horisaka K. The involvement of serotonergic and dopaminergic system in hypothermia induced in mice by intracerebroventricular injection of serotonin. Jpn. J. Pharmacol. 48:1988;145-148.
19. Yamada J., Sugimoto Y., Ujikawa M. The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice. Eur. J. Pharmacol. 383:1999;49-51.