Frequent loss of gelsolin expression in non-small cell lung cancers of heavy smokers

Cancer Research

Volumn 58, Issue 2, 1998, Pages 322-327

  Dosaka Akita, Hirotoshi ^a,c   Hommura, Fumihiro ^a   Fujita, Hisakazu ^b   Kinoshita, Ichiro ^a   Nishi, Motoi ^d   Morikawa, Toshiaki ^c   Katoh, Hiroyuki ^c   Kawakami, Yoshikazu ^a   Kuzumaki, Noboru ^b  

^a Sapporo Medical University   (Japan)

^b CANCER INSTITUTE   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GELSOLIN;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; FEMALE; GENE DELETION; GENE FREQUENCY; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOKING HABIT; TUMOR SUPPRESSOR GENE;

AGED; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CHROMATOGRAPHY, LIQUID; DNA, NEOPLASM; FEMALE; GELSOLIN; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; SMOKING; TUMOR CELLS, CULTURED;

EID: 0031984217     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Minna, J. D., Sekido, Y., Fong, K. M., and Gazdar, A. F. Molecular biology of lung cancer. In: V. T. DeVita, S. Hellman, and S. A. Rosenberg (eds.). Cancer: Principles and Practice of Oncology, pp. 849-857. Philadelphia: Lippincott-Raven, 1997.
2. Harbour, J. W., Lai, S-L., Whang-Peng, J., Gazdar, A. F., Minna, J. D., and Kaye, F. J. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science (Washington DC), 241: 353-357, 1988.
3. Takahashi, T., Nau, M. M., Chiba, I., Birrer, M., Rosenberg, R. K., Vinocour, M., Levitt, M., Pass, H., Gazdar, A. F., and Minna, J. D. p53: a frequent target for genetic abnormalities in lung cancer. Science (Washington DC), 246: 491-494, 1989.
4. Kamb, A., Gruis, N. A., Weaver-Feldhaus J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., III, Johnson, B. E., and Skolnick, M. H. A cell cycle regulator potentially involved in genesis of many tumor types. Science (Washington DC), 264: 436-440, 1994.
5. Nobori, T., Miura, K., Wu, D. J., Lois, A., Takabayashi, K., and Carson, D. A. Deletion of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368: 753-756, 1994.
6. Rodenhuis, S., Slebos, R. J., Boot, A. J. M., Evers, S. G., Mooi, W. J., Wagenaar, S. S., van Bodegom, P. C., and Bos, J. L. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res., 48: 5738-5741, 1988.
7. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54: 4855-4878, 1994.
8. INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activity. Cancer Res., 56: 5557-5562, 1996.
9. Sozzi, G., Sard, L., De Gregorio, L., Marchetti, A., Musso, K., Buttitta, F., Tornielli, S., Pellegrini, S., Luisa, M., Veronese, L., Manenti, G., Incarbone, M., Chella, A., Angeletti, C. A., Pastorino, U., Huebner, K., Bevilaqua, G., Pilotti, S., Croce, C. M., and Pierotti, M. A. Association between cigarette smoking and FHIT gene alterations in lung cancer. Cancer Res., 57: 2124-2123, 1997.
10. IARC. Tobacco Smoking. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, IARC Scientific Publ. No. 38. Lyon, France: IARC, 1986.
11. Shopland, D. R., Eyre, H. J., and Pechacek, T. F. Smoking-attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States? J. Natl. Cancer Inst. (Bethesda), 83: 1142-1148, 1991.
12. Tanaka, M., Müllauer, L., Ogiso Y., Fujita, H., Moriya, S., Furuuchi, K., Harabayashi, T., Shinohara, N., Koyanagi, T., and Kuzumaki, N. Gelsolin: a candidate for suppressor of human bladder cancer. Cancer Res., 55: 3228-3232, 1995.
13. Yin, H. L. Gelsolin: calcium-and polyphosphoinositide-regulated actin-modulating protein. BioEssays, 7: 176-179, 1987.
14. Stossel, T. P. From signal to pseudopod. How cells control cytoplasmic actin assembly. J. Biol. Chem., 264: 18261-18264, 1989.
15. Janmey, P. A. Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly. Annu. Rev. Physiol., 56: 169-191, 1994.
16. Ozelius, L. J., Kwiatkowski, D. J., Schuback, D. E., Breakefield, X. O., Wexler, N. S., Gusella, J. F., and Haines, J. L. A genetic linkage map of human chromosome 9q. Genomics, 14: 715-720, 1992.
17. Merlo, A., Gabrielson, E., Askin, F., and Sidransky, D. Frequent loss of chromosome 9 in human primary non-small cell lung cancer. Cancer Res., 54: 640-642, 1994.
18. Sato, S., Nakamura, Y., and Tsuchiya, E. Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung. Cancer Res., 54: 5652-5655, 1994.
19. Arteaga, C. L., Johnson M. D., Todderud, G., Coffey, R. J., Carpenter, G., and Page, D. L. Elevated content of the tyrosine kinase substrate phospholipase C-γ1 in primary human breast carcinomas. Proc. Natl. Acad. Sci. USA, 88: 10435-10439, 1991.
20. WHO. The World Health Organization histological typing of lung tumors: second edition. Am. J. Clin. Pathol., 77: 123-136, 1982.
21. Beahrs, O. H., Henson, D. E., Hutter, R. V. P., and Kennedy, B. J. Lung. In: Manual for Staging of Cancer, Ed. 4, pp. 115-122. Chicago: American Joint Committee on Cancer, 1992.
22. Dosaka-Akita, H., Akie K., Hiroumi, H., Kinoshita, I., Kawakami, Y., and Murakami, A. Inhibition of proliferation by L-myc antisense DNA for the translational initiation site in human small cell lung cancer. Cancer Res., 55: 1559-1564, 1995.
23. Mehta, C. R., and Patel, N. R. A network algorithm for performing Fisher's exact test in r × c contingency tables. J. Am. Stat. Assoc., 78: 427-434, 1983.
24. Cox, D., and Snell, E. Analysis of Binary Data, Ed. 2. London: Chapman and Hall, Ltd., 1989.
25. Kaplan, E. L., and Meier, P. Nonparametric estimation for incomplete observations. J. Am. Stat. Assoc., 53: 457-481, 1958.
26. Gehan, E. A. A generalized Wilcoxon test for comparing arbitrarily singly-censored samples. Biometrika. 52: 203-223, 1965.
27. Kapanci, Y., Ribaux, C., Chaponnier, C., and Gabbiani, G. Cytoskeletal features of alveolar myofibroblasts and pericytes in normal human and rat lung. J. Histochem. Cytochem., 40: 1955-1963, 1992.
28. Medina, D., Kittrell, F. S., Oborn, C. J., and Schwartz, M. Growth factor dependency and gene expression in preneoplastic mouse mammary epithelial cells. Cancer Res., 53: 668-674, 1993.
29. Asch, H. L., Head, K., Dong, Y., Natoli, F., Winston, J. S., Conolly, J. L., and Asch, B. B. Widespread loss of gelsolin in breast cancers of humans, mice, and rats. Cancer Res., 56: 4841-4845, 1996.
30. Moriya, S., Yanagihara, K., Fujita, H., and Kuzumaki, N. Differential expression of HSP90, gelsolin and GST-π in human gastric carcinoma cell lines. Int. J. Oncol., 5: 1347-1351, 1994.
31. Chaponnier, C., and Gabbiani, G. Gelsolin modulation in epithelial and stromal cells of mammary carcinoma. Am. J. Pathol., 134: 597-603, 1989.
32. Porter, R. M., Holme, T. C., Newman, E. L., Hopwood, D., Wilkinson, J. M., and Cuschieri, A. Monoclonal antibodies to cytoskeletal proteins: an immunohistochemical investigation of human colon cancer. J. Pathol., 170: 435-440, 1993.
33. Fujita, H., Suzuki, H., Kuzumaki, N., Müllauer, L., Ogiso, Y., Oda, A., Ebisawa, K., Sakurai, T., Nonomura, Y., and Kijimoto-Ochiai, S. A specific protein, p92, detected in flat revenants derived from NIH/3T3 transformed by human activated c-Ha-ras oncogene. Exp. Cell Res., 186: 115-121, 1990.
34. Müllauer, L., Fujita, H., Suzuki, H., Katabami, M., Hitomi, Y., Ogiso, Y., and Kuzutnaki, N. Elevated gelsolin and α-actin expression in a flat revenant R1 of Ha-ras oncogene-transformed NIH/3T3 cells. Biochem. Biophys. Res. Commun., 171: 852-859, 1990.
35. Vandekerckhove, J., Bauw, G., Vancompernolle, K., Honore B., and Celis, J. Comparative two-dimensional gel analysis and microsequencing identifies gelsolin as one of the most prominent downregulated markers of transformed human fibroblast and epithelial cells. J. Cell Biol., 111: 95-102, 1990.
36. Müllauer, L., Fujita, H., Ishizaki, A., and Kuzumaki, N. Tumor-suppressive function of mutated gelsolin in ras-transformed cells. Oncogene, 8: 2531-2536, 1993.
37. Witke, W., Sharpe, A. H., Hartwig, J. H., Azuma, T., Stossel, T. P., and Kwiatkowski, D. J. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell, 81: 41-51, 1995.
38. INK4 protein induction by 5-aza-2′-deoxycytidine. Oncogene, 11: 1211-1216, 1995.
39. Belinsky, S. A., Nikula, K. J., Baylin, S. B., and Issa, J-P. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc. Natl. Acad. Sci. USA. 93: 4045-4050, 1996.
40. Ruggeri, B., DiRado, M., Zhang, S. Y., Bauer, B., Goodrow, T., and Klein-Szanto, A. J. P. Benzo(a)pyrene-induced murine skin tumors exhibit frequent and characteristic G-to-T mutations in the p53 gene. Proc. Natl. Acad. Sci. USA, 90: 1013-1017, 1993.
41. Rodenhuis, S., and Slebos, R. J. C. Clinical significance of ras oncogene activation in human lung cancer. Cancer Res., 52 (Suppl.): 2665s-2669s, 1992.
42. Denissenko, M. F., Pao, A., Tang, M., and Pfeifer, G. P. Preferential formation of benzo(a)pyrene adducts at lung cancer mutational hotspots in p53. Science (Washington DC), 274: 430-432, 1996.