Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression

Journal of Biological Chemistry

Volumn 275, Issue 6, 2000, Pages 3761-3766

  Azuma, Toshifumi ^a   Koths, Kirston ^b   Flanagan, Lisa ^a   Kwiatkowski, David ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; FIBRONECTIN; GELSOLIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; INHIBITION KINETICS; MOUSE; NONHUMAN; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CASPASES; ENZYME INHIBITORS; FIBROBLASTS; GELSOLIN; HUMANS; JURKAT CELLS; KINETICS; LIVER; MICE; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES;

ANIMALIA;

EID: 0034635549     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.6.3761     Document Type: Article

References (32)

1. Green, D. (1998) Cell 94, 695-698
2. Salvesen, G. S., and Dixit, V. M. (1997) Cell 91, 443-446
3. Vauz, D. L., Haecker, G., and Strasser, A. (1994) Cell 76, 777-779
4. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., Litwack, G., and Alnemri, E. S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14486-14491
5. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S., Ahmad, M., Alnemri, E., and Wang, X. (1997) Cell 91, 479-489
6. Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D. (1997) Science 275, 1132-1136
7. LaCasse, E. C., Baird, S., Korneluk, R. G., and MacKenzie, A. E. (1998) Oncogene 17, 3247-3259
8. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., and Reed, J. C. (1997) Nature 388, 300-304
9. Kothakota, S., Azuma, T., Reinhard, C., Klippel, A., Tang, J., Chu, K., McGarry, T. J., Kirschner, M. W., Koths, K., Kwiatkowski, D. J., and Williams, L. T (1997). Science 278, 294-298
10. Geng, Y. J., Azuma, T., Tang, J. X., Hartwig, J. H., Muszynski, M., Wu, Q., Libby, P., and Kwiatkowski, D. J. (1998) Eur. J. Cell Biol. 77, 294-302
11. Ohtsu, M., Sakai, N., Fujita, H., Kashiwagi, M., Gasa, S., Shimizu, S., Eguchi, Y., Tsujimoto, Y., Sakiyama, Y., Kobayashi, K., and Kuzumaki, N. (1997) EMBO J. 16, 4650-4656
12. Witke, W., Sharpe, A. H., Hartwig, J. H., Azuma, T., Stossel, T. P., and Kwiatkowski, D. J. (1995) Cell 81, 41-51
13. Azuma, T., Witke, W., Stossel, T. P., Hartwig, J. H., and Kwiatkowski, D. J. (1998) EMBO J. 17, 1362-1370
14. Janmey, P. A., Lamb, J., Allen, P. G., and Matsudaira, P. T. (1992) J. Biol. Chem. 267, 11818-11823
15. Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. (1998) Nature 391, 43-50
16. Hartwig, J. H., Kung, S., Kovacsovics, T., Janmey, P. A., Cantley, L. C., Stossel, T. P., and Toker, A. (1996) J. Biol. Chem. 271, 32986-32993
17. Janmey, P. A., and Stossel, T. P. (1989) J. Biol. Chem. 264, 4825-4831
18. Meerschaert, K., Corte, V. D., Yvette, D. V., Vandekerckhove, J., and Gettemans, J. (1998) EMBO J. 17, 5923-5932
19. Chellaiah, M., and Hruska, K. (1996) Mol. Biol. Cell 7, 743-753
20. Na, S., Chuang, T. H., Cunningham, A., Tun, T. G., Hanke, J. H., Bokoch, G. M., and Danley, D. E. (1996) J. Biol. Chem. 271, 11209-11213
21. Chen, P., Murphy-Ullrich, J. E., and Wells, A. (1996) J. Cell Biol. 134, 689-698
22. Kwiatkowski, D. J. (1999) Curr. Opin. Cell Biol. 11, 103-108
23. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
24. Cryns, V., and Yuan, J. (1998) Genes Dev. 12, 1551-1570
25. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., and Reed, J. C. (1997) Nature 388, 300-304
26. Li, H., Zhu, H., Xu, C. J., and Yuan, J. (1998) Cell 94, 491-501
27. Cheng, E. H., Kirsch, D. G., Clem, R. J., Ravi, R., Kastan, M. B., Bedi, A., Ueno, K., and Hardwick, J. M. (1997) Science 278, 1966-1968
28. Clem, R. J., Cheng, E. H., Karp, C. L., Kirsch, D. G., Ueno, K., Takahashi, A., Kastan, M. B., Griffin, D. E., Earnshaw, W. C., Veliuona, M. A., and Hardwick, J. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 554-559
29. Frisch, S. M., and Francis, H. (1994) J. Cell Biol. 124, 619-626
30. Salvesen, G. S., and Dixit, V. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 10964-10967
31. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., Potter, J., Yoshida, E., Kaufman, S. A., Lowe, S. W., Penninger, J. M., and Mak, T. W. (1998) Cell 94(3), 339-352
32. Kuida, K., Zheng, T. S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P., and Flavell, R. A. (1996) Nature 384, 368-372