Excitotoxicity-Induced Endocytosis Confers Drug Targeting in Cerebral Ischemia

Annals of Neurology

Volumn 65, Issue 3, 2009, Pages 337-347

  Vaslin, Anne ^a   Puyal, Julien ^a   Clarke, Peter G H ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CLATHRIN; DEXTRAN; DYNAMIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; N METHYL DEXTRO ASPARTIC ACID; PEROXIDASE; PROTEOHEPARAN SULFATE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG TARGETING; ENDOCYTOSIS; EXCITOTOXICITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION;

ALANINE; ANIMALS; ANIMALS, NEWBORN; BRAIN ISCHEMIA; CELLS, CULTURED; CEREBRAL CORTEX; DEXTRANS; DISEASE MODELS, ANIMAL; DYNAMIN I; ENDOCYTOSIS; EXCITATORY AMINO ACID AGONISTS; FLUORESCEIN-5-ISOTHIOCYANATE; GENE PRODUCTS, TAT; GREEN FLUORESCENT PROTEINS; HORSERADISH PEROXIDASE; INJECTIONS, INTRAVENTRICULAR; LYSINE; MALE; MUTATION; N-METHYLASPARTATE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION; VESICULAR TRANSPORT PROTEINS;

EID: 65249138761     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.21584     Document Type: Article

References (39)

1. Mehta SL, Manhas N, Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev 2007;54:34-66.
2. Ferriero DM. Neonatal brain injury. N Engl J Med 2004;351: 1985-1995.
3. Liu Y, Wong TP, Aarts M, et al. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 2007;27:2846-2857.
4. Joliot A, Prochiantz A. Transduction peptides: from technology to physiology. Nat Cell Biol 2004;6:189-196.
5. Futaki S. Membrane-permeable arginine-rich peptides and the translocation mechanisms. Adv Drug Deliv Rev 2005;57: 547-558.
6. Vives E, Brodin P, Lebleu B. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 1997; 272:16010-16017.
7. Richard JP, Melikov K, Brooks H, et al. Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors. J Biol Chem 2005;280: 15300-15306.
8. Saalik P, Elmquist A, Hansen M, et al. Protein cargo delivery properties of cell-penetrating peptides. A comparative study. Bioconjug Chem 2004;15:1246-1253.
9. Wadia JS, Stan RV, Dowdy SF. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Nat Med 2004;10:310-315.
10. Soane L, Fiskum G. TAT-mediated endocytotic delivery of the loop deletion Bcl-2 protein protects neurons against cell death. J Neurochem 2005;95:230-243.
11. Aarts M, Liu Y, Liu L, et al. Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions. Science 2002;298:846-850.
12. Borsello T, Clarke PGH, Hirt L, et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med 2003;9:1180-1186.
13. Guegan C, Braudeau J, Couriaud C, et al. PTD-XIAP protects against cerebral ischemia by anti-apoptotic and transcriptional regulatory mechanisms. Neurobiol Dis 2006;22:177-186.
14. Clarke PGH. Labelling of dying neurones by peroxidase injected intravascularly in chick embryos. Neurosci Lett 1982;30: 223-228.
15. Hornung JP, Koppel H, Clarke PGH. Endocytosis and autophagy in dying neurons: an ultrastructural study in chick embryos. J Comp Neurol 1989;283:425-437.
16. Vaslin A, Puyal J, Borsello T, et al. Excitotoxicity-related endocytosis in cortical neurons. J Neurochem 2007;102:789-800.
17. Borsello T, Croquelois K, Hornung JP, et al. N-methyl-D- aspartate-triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway. Eur J Neurosci 2003;18:473-485.
18. Borsello T, Bressoud R, Mottier V, et al. Kainate-induced endocytosis in retinal amacrine cells. J Comp Neurol 2003;465: 286-295.
19. Wang Y, Ju W, Liu L, et al. alpha-Amino-3-hydroxy-5- methylisoxazole-4- propionic acid subtype glutamate receptor (AMPAR) endocytosis is essential for N-methyl-D-aspartateinduced neuronal apoptosis. J Biol Chem 2004;279: 41267-41270.
20. Aarts MM, Arundine M, Tymianski M. Novel concepts in excitotoxic neurodegeneration after stroke. Expert Rev Mol Med 2003;2003:1-22.
21. Renolleau S, Aggoun-Zouaoui D, Ben-Ari Y, et al. A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat-morphological changes indicative of apoptosis. Stroke 1998;29:1454-1460.
22. Mlynarik V, Kohler I, Gambarota G, et al. Quantitative proton spectroscopic imaging of the neurochemical profile in rat brain with microliter resolution at ultra-short echo times. Magn Reson Med 2008;59:52-58.
23. Clague MJ. Molecular aspects of the endocytic pathway. Biochem J 1998;336(pt 2):271-282.
24. Gaudreault SB, Blain JF, Gratton JP, et al. A role for caveolin-1 in post-injury reactive neuronal plasticity. J Neurochem 2005; 92:831-839.
25. Jasmin JF, Malhotra S, Singh DM, et al. Caveolin-1 deficiency increases cerebral ischemic injury. Circ Res 2007;100:721-729.
26. Nichols B. Caveosomes and endocytosis of lipid rafts. J Cell Sci 2003;116:4707-4714.
27. Nixon RA, Cataldo AM, Mathews PM. The endosomallysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochem Res 2000;25:1161-1172.
28. Cataldo AM, Peterhoff CM, Troncoso JC, et al. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol 2000;157:277-286.
29. Yoshimi K, Takeda M, Nishimura T, et al. An immunohistochemical study of MAP2 and clathrin in gerbil hippocampus after cerebral ischemia. Brain Res 1991;560:149-158.
30. Yoshimi K, Iwata N, Takeda M, et al. Ischaemia-induced change in clathrin preceding delayed neuronal death. Neuroreport 1995;6:453-456.
31. Vaslin A, Puyal J, Borsello T, et al. Excitotoxicity-related endocytosis in cortical neurons. J Neurochem 2007;102:789-800.
32. Duchardt F, Fotin-Mleczek M, Schwarz H, et al. A comprehensive model for the cellular uptake of cationic cellpenetrating peptides. Traffic 2007;8:848-866.
33. Fittipaldi A, Ferrari A, Zoppe M, et al. Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins. J Biol Chem 2003;278:34141-34149.
34. Console S, Marty C, Garcia-Echeverria C, et al. Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. J Biol Chem 2003;278:35109-35114.
35. Kaplan IM, Wadia JS, Dowdy SF. Cationic TAT peptide transduction domain enters cells by macropinocytosis. J Control Release 2005;102:247-253.
36. Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature 2003;422:37-44.
37. Kirkham M, Parton RG. Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers. Biochim Biophys Acta 2005;1745:273-286.
38. Lajoie P, Nabi IR. Regulation of raft-dependent endocytosis. J Cell Mol Med 2007;11:644-653.
39. Gundelfinger ED, Kessels MM, Qualmann B. Temporal and spatial coordination of exocytosis and endocytosis. Nat Rev Mol Cell Biol 2003;4:127-139.