Effects of an oral growth hormone secretagogue in older adults

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 4, 2009, Pages 1198-1206

  White, Heidi K ^a   Petrie, Charles D ^b   Landschulz, William ^c   MacLean, David ^d   Taylor, Ann ^e   Lyles, Kenneth ^a   Wei, Jeanne Y ^f   Hoffman, Andrew R ^g   Salvatori, Roberto ^h   Ettinger, Mark P ⁱ   Morey, Miriam C ^a   Blackman, Marc R ^j   Merriam, George R ^k  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d BROWN UNIVERSITY   (United States)

^e NOVARTIS   (United States)

^f UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^g STANFORD UNIVERSITY   (United States)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ RADIANT RESEARCH   (United States)

^j VETERANS AFFAIRS MEDICAL CENTER   (United States)

^k UNIVERSITY OF WASHINGTON   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CAPROMORELIN; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE; PLACEBO; SOMATOMEDIN C;

AGED; ANALYTICAL PARAMETERS; APPETITE; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EVENING DOSAGE; FATIGUE; FEMALE; FUNCTIONAL DISEASE; GLUCOSE BLOOD LEVEL; HUMAN; INSOMNIA; INSULIN RESISTANCE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT DURATION; TREATMENT RESPONSE; WALKING SPEED;

EID: 65249108287     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-0632     Document Type: Article

References (48)

1. Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB 1994 A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49:M85-M94
2. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB 1995 Lower- extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 332:556-561
3. Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA, Bain RP 1981 Impaired growth hormone secretion in the adult population. J Clin Invest 67:1361-1369
4. Florini JR, Ewton DZ, Coolican SA 1996 Growth hormone and insulin-like growth factor system in myogenesis. Endocr Rev 17:481-517
5. Ho KY, Evans WS, Blizzard RM, Veldhuis JD, Merriam GR, Samojlik E, Furlanetto R, Rogol AD, Kaiser DL, Thorner MO 1987 Effects of sexandage on the 24-hour profile of GH secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 64:51-58
6. Corpas E, Harman SM, Blackman MR 1993 Human growth hormone and human aging. Endocr Rev 14:20 -39
7. Corpas E, Harman SM, Pineyro MA, Roberson R, Blackman MR 1992 Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the de-creased GH and insulin-like growth factor-Ilevels in old men. J Clin Endocrinol Metab 75:530-535
8. Chapman IM, Hartman ML, Pezzoli SS, Thorner MO 1996 Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone-releasing peptide mimetic, L-692,429, in older adults-a clinical research center study. J Clin Endocrinol Metab 81:2874-2880
9. Chapman IM, Bach MA, Cauter EV, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KY, Skiles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO 1996 Stimulation of the growth hormone (GH)-insulin-like growth factor axis by daily oral administration of a GH secretagogue (MK-677) in healthy elderly subjects. J Clin Endocrinol Metab 81:4249-4257
10. Harman SM, Blackman MR 2004 Use of growth hormone for prevention or treatment of effects of aging. J Gerontol A Biol Sci Med Sci 59A:652-658
11. Liu H, Bravata DM, Olkin I, Nayak S, Roberts B, Garber AM, Hoffman AR 2007 Systematic review: the safety and efficacy of growth hormone in the healthyelderly. Ann Intern Med 146:104-115
12. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE 1990 Effects of human growth hormone in men over 60 years old. N Engl J Med 323:1-6
13. Taaffe DR, Pruit L, Reim J, Hintz RL, Butterfield G, Hoffman AR, Marcus R 1994 Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab 79: 1361-1366
14. Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GAW, Schambelan M, Grunfeld C 1996 Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 124: 708-716
15. Blackman MR, Sorkin JD, Munzer T, Bellantoni MF, Busby-Whitehead J, Stevens TE, Jayme J, O'Connor KG, Christmas C, Tobin JD, Stewart KJ, Cottrell E, St Clair C, Pabst KM, Harman SM 2002 Growth hormone and sex steroid administration in aged women and men: a randomized controlled trial. JAMA 288:2282-2292
16. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, ChouM, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH 1996 A receptor in the pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
17. Pan LC, Carpino PA, Leftker BA, Ragan JA, Toler SM, Pettersen JC, Nettleton DO, NgO, Pirie CM, Chidsey-Frink K, Lu B, Nickerson DF, Tess DA, Mullins MA, MacLean DB, DaSilva-Jardine PA, Thompson DD 2001 Preclinical pharmacology of CP-424,391, an orally active pyrazolidinone-piperidine growth hormone secretagogue. Endocrine 14:121-132
18. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasingacylated peptide from stomach. Nature 402:656-660
19. SmithRG, ChengK, SchoenWR, PongSS, HickeyG, JacksT, ButlerB, Chan W, Chaung L, Judith F, Taylor J, Wyratt MJ, Fisher MH 1993 A nonpeptidyl growth hormone secretagogue. Science 260:1640 -1643
20. van der Lely AJ, Tschop M, Heiman ML, Ghigo E 2004 Biological, physiological, pathological, and pharmacological aspects of ghrelin. Endocr Rev [Erratum (2004) 25:866] 25:426-557
21. Carpino PA, Leftker BA, Toler SM, Pan LC, Hadcock JR, Murray MC, Cook ER, DiBrino JN, DeNinno SL, Chidsey-Frink KL, Hada WA, Inthavongsay J, Lewis SK, Mangano FM, Mullins MA, NickersonDF, Ng O, Pirie CM, Ragan JA, Rose CR, Tess DA, Wright AS, Yu L, Zawistoski MP, Pettersen JC, DaSilva-Jardine PA, Wilson TC, Thompson DD 2002 Discovery and biological characterization of capromorelin analogues with extended half-lives. Bioorg Med Chem Lett 12:3279-3282
22. Carpino PA, Leftker BA, Toler SM, Pan LC, Hadcock JR, Cook ER, DiBrino JN, Campeta AM, DeNinno SL, Chidsey-Frink KL, Hada WA, Inthavongsay J, Mangano FM, Mullins MA, NickersonDF, Ng O, Pirie CM, RaganJA, Rose CR, Tess DA, Wright AS, Yu L, Zawistoski MP, DaSilva-Jardine PA, Wilson TC, Thompson DD 2003 Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs). Discoveryofcapromorelin. Bioorg Med Chem 11:581-590
23. Tinetti ME, Inouye SK, Gill TM, Doucette JT 1995 Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 273:1348-1353
24. Ware JE, Snow KK, Kosinski M, Gandek B 1993 SF-36 Health Survey Manual and Interpretation Guide. Boston: The Health Institute, New England Medical Center
25. Nagi S 1976 An epidemiology of disability among adults in the United States. Milbank Mem Fund Q 54:439-468
26. Onder G, Penninx BW, Ferrucci L, Fried LP, Guralnik JM, Pahor M 2005 Measures of physical performance and risk for progressive and catastrophic disability: results from the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci 60:74-79
27. Bean JF, Kiely DK, Herman S, Leveille SG, Mizer K, Frontera WR, Fielding RA 2002 The relationship between leg power and physical performance in mobility-limited older people. J Am Geriatr Soc 50:461-467
28. Ware JE, Kosinski M, Keller SD 1994 SF-36 Physical and Mental Health Summary Scales: A User's Manual. Boston: The Health Institute, New England Medical Center
29. Folstein MF, Folstein SE, McHugh PR 1975 Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198
30. Yesavage JA, Brink TL, Rose TL, Lum O, Huang V, Adey M, Leirer VO 1983 Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 17:37-49
31. Stewart AL, Ware JE 1992 Measuring functioning and well-being: The Medical Outcomes Study Approach. Durham, NC: Duke University Press; 235-259, 399 -400
32. Ainsworth BE, Haskell WL, Leon AS, Jacobs DR, Montoye HJ, Sallis JF, Paffenbarger Jr RS 1993 Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25:71-80
33. Hrebicek J, Janout V, Malincikova J, Horakova D, Cizek L 2002 Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Clin Endocrinol Metab 87:144-147
34. Muniyappa R, Lee S, ChenH, QuonM2008 Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 294:E15-E26
35. Merriam GR, Wachter KW1982 Algorithms for the studyofepisodic hormone secretion. Am J Physiol 243:E310 -E318
36. Svensson J, Lonn L, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Baylink D, Mohan S, Bengtsson BA 1998 Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. J Clin Endocrinol Metab 83:362-369
37. Nass R, Pezzoli SS, Oliveri MC, Patrie JT, Harrell FE, Clasey JL, Haymsfield SB, Bach MA, Vance ML, Thorner MO 2008 Effects ofan oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. Ann Intern Med 149:601-611
38. Brill KT, Weltman AL, Gentili A, Patrie JT, Fryburg DA, Hanks JB, Urban RJ, Veldhuis JD 2002 Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. J Clin Endocrinol Metab 87:5649 -5657
39. Veldhuis JD, Patrie JM, Frick K, Weltman JY, Weltman AL 2005 Administration of recombinant human GHRH-1,44-amide for 3 months reduces abdominal visceral fat mass and increases physical performance measures in postmenopausal women. Eur J Endocrinol 153:669 -677
40. Hennessey JV, Chromiak JA, DellaVentura S, Reinert SE, Puhl J, Kiel DP, Rosen CJ, Vandenburgh H, MacLean DB 2001 Growth hormone administration and exercise effects on muscle fiber type and diameter in moderately frail older people. J Am Geriatr Soc 49:852-858
41. Nelson ME, Layne JE, Bernstein MJ, Nuernberger A, Castaneda C, Kaliton D, Hausdorff J, Judge JO, Buchner DM, Roubenoff R, Fiatarone Singh MA 2004 The effects of multidimensional home-based exercise on functional performance in elderly people. J Gerontol 59A:154-160
42. Fiatarone MA, O'Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Kehayias JJ, Lipsitz LA, Evans WJ 1994 Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330:1769 -1775
43. Rahim A, O'Neill PA, Shalet SM 1998 Growth hormone status during long- term hexarelin therapy. J Clin Endocrinol Metab 83:1644 -1649
44. Blake AD, SmithRG 1991 Desensitization studies using perifused rat pituitary cells show growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D- Phe-Lys-NH2 stimulate growth hormone release through distinct receptor sites. J Endocrinol 129:11-19
45. SmithRG, JiangH, SunY 2005 Developments in ghrelin biology and potential clinical relevance. Trends Endocrinol Metab 16:436 -442
46. Cappola AR, Xue QL, Ferrucci L, Guralnik JM, Volpato S, Fried LP 2003 Insulin-like growth factor I and interleukin-6 contribute synergistically to disabilityand mortality in older women. J Clin Endocrinol Metab 88:2019 -2025
47. King MK, Gay DM, Pan LC, McElmurray III JH, Hendrick JW, Pirie C, Morrison A, Ding C, Mukherjee R, Spinale FG 2001 Treatment with a growth hormone secretagogue in a model of developing heart failure: effects on ventricular and myocyte function. Circulation 103:308 -313
48. Sun Y, Asnicar M, Smith R 2007 Central and peripheral roles of ghrelin on glucose homeostasis. Neuroendocrinology 86:215-228