Growth hormone status during long-term hexarelin therapy

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 5, 1998, Pages 1644-1649

  Rahim, A ^a   O'Neill, P A ^b   Shalet, S M ^a  

^a CHRISTIE HOSPITAL   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; DEOXYPYRIDINOLINE; GROWTH HORMONE; HEXARELIN; OSTEOCALCIN; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; PYRIDINOLINE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

AGED; AREA UNDER THE CURVE; ARTICLE; BODY COMPOSITION; BONE DENSITY; CLINICAL ARTICLE; DRUG EFFECT; DRUG MECHANISM; DRUG WITHDRAWAL; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; HUMAN; OSSIFICATION; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031724499     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.83.5.4812     Document Type: Article

References (37)

1. Ghigo E, Arvat E, Gianotti L, et al. 1994 Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man. J Clin Endocrinol Metab. 78:693-698.
2. Ghigo-E, Arvat-E, Gianotti-L, et al. 1996 Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging. Eur J Endocrinol. 135:407-412.
3. Cella SG, Cerri CG, Daniel S, et al. 1996 Sixteen weeks of hexarelin therapy in aged dogs: effects on the somatotropic axis, muscle morphology, and bone metabolism. J Gerontol A Biol Sci Med Sci. 51:B439-B447.
4. Kollerup G, Thamsborg G, Bhatia H, Sorensen OH. 1992 Quantitation of urinary hydroxypyridinium cross-links from collagen by high-performance liquid chromatography. Scand J Clin Lab Invest. 52:657-662.
5. Arsenijevic Y, Rivest RW, Eshkol A, Sizonenko PC, Aubert ML. 1987 Plasma growth hormone (GH) response to intravenous GH-releasing factor (GRF) in adult rats: evidence for transient pituitary desensitization after GRF stimulation. Endocrinology. 121:1487-1496.
6. Kirk JM, Trainer PJ, Majrowski WH, Murphy J, Savage MO, Besser GM. 1994 Treatment with GHRH(1-29)NH2 in children with idiopathic short stature induces a sustained increase in growth velocity. Endocrinology. 41:487-493.
7. 2 in age-advanced men and women. J Clin Endocrinol Metab. 82:1472-1479.
8. Laron Z, Frenkel J, Gil-Ad I, et al. 1994 Growth hormone releasing activity by intranasal administration of a synthetic hexapeptide (hexarelin). Clin Endocrinol (Oxf). 41:539-541.
9. Klinger B, Silbergeld A, Deghenghi R, Frenkel J, Laron Z. 1996 Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children. Eur J Endocrinol. 134:716-719.
10. Abrams RL, Grumbach MM, Kaplan SL. 1971 The effect of administration of human growth hormone on the plasma growth hormone, cortisol, glucose, and free fatty acid response to insulin: evidence for growth hormone autoregulation in man. J Clin Invest. 50:940-950.
11. Nakamot JM, Gertner JM, Press CM, Hintz RL, Rosenfeld RG, Genel M. 1986 Suppression of the growth hormone (GH) response to clonidine and GH-releasing hormone by exogenous GH. J Clin Endocrinol Metab. 62:822-826.
12. Lanzi R, Tannenbaum GS. 1992 Time-dependent reduction and potentiation of growth hormone (GH) responsiveness to GH-releasing factor induced by exogenous GH: role for somatostatin. Endocrinology. 130:1822-1828.
13. Burton KA, Kabigting EB, Clifton DK, Steiner RA. 1992 Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypothalamic somatostatin neurons. Endocrinology. 131:958-963.
14. Sheppard MC, Kronheim S, Pimstone BL. 1978 Stimulation by growth hormone of somatostatin release from the rat hypothalamus in vitro. Clin Endocrinol. 9:583-586.
15. Hurley DL, Phelps CJ. 1993 Altered growth hormone-releasing hormone mRNA expression in transgenic mice with excess or deficient endogenous growth hormone. Mol Cell Neurosci. 4:237-244.
16. Massoud AF, Hind marsh PC, Brook CG. 1995 Hexarelin induced growth hormone release is influenced by exogenous growth hormone. Clin Endocrinol. 43:617-621.
17. Arvat E, Di-Vito L, Gianotti L, et al. 1997 Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in man. Metabolism. 46:83-88.
18. Ceda GP, Davis RG, Rosenfeld RG, Hoffman AR. 1987 The growth hormone (GH)-releasing hormone (GHRH)-GH-somatomedin axis: evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II. Endocrinology. 120:1658-1662.
19. Ceda GP, Hoffman AR, Silverberg GD, Wilson DM, Rosenfeld RG. 1985 Regulation of growth hormone release from cultured human pituitary adenomas by somatomedins and insulin. J Clin Endocrinol Metab. 60:1204-1209.
20. Yamashita S, Melmed S. 1986 Insulin-like growth factor I regulation of growth hormone gene transcription in primary rat pituitary cells. J Clin Invest. 79:449-452.
21. Yamashita S, Weiss M, Melmed S. 1986 Insulin-like growth factor I regulates growth hormone secretion and messenger ribonucleic acid levels in human pituitary tumor cells. J Clin Endocrinol Metab. 63:730-735.
22. Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL. 1981 Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science. 212:1279-1281.
23. Davis JR, Sheppard MC, Shakespear RA, Lynch SS, Clayton RN. 1986 Does growth hormone releasing factor desensitize the somatotroph? Interpretation of responses of growth hormone during and after 10-hour infusion of GRF 1-29 amide in man. Clin Endocrinol (Oxf). 24:135-140.
24. Huhn WC, Hartman ML, Pezzoli SS, Thorner MO. 1993 Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus. J Clin Endocrinol Metab. 76:1202-1208.
25. Finkelstein JW, Roffwarg HP, Boyar RM, et al. 1972 Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J Clin Endocrinol Metab. 35:665-670.
26. Dudl RJ, Ensinck JW, Palmer HE, Williams RH. 1973 Effect of age on growth hormone secretion in man. J Clin Endocrinol Metab. 37:11-16.
27. Ho KY, Evans WS, Blizzard RM, et al. 1987 Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab. 64:51-58.
28. Zadik Z, Chalew SA, McCarter Jr RJ, Meistas M, Kowarski AA. 1985 The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab. 60:513-516.
29. Rudman D. 1985 Growth hormone, body composition, and aging. J Am Geriatr Soc. 3:800-807.
30. Forbes G. 1976 The adult decline in lean body mass. Hum Biol. 48:161-173.
31. Jorgensen JO, Pedersen SA, Thuesen L, et al. 1989 Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet. 1:1221-1225.
32. Salomon F, Cuneo RC, Hesp R, Sonksen PH. 1989 The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med. 321:1797-1803.
33. Thompson JL, Butterfield GE, Marcus R, et al. 1995 The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women. J Clin Endocrinol Metab. 80:1845-1852.
34. Taaffe DR, Pruitt L, Reim J, et al. 1994 Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab. 79:1361-1366.
35. Holloway L, Butterfield G, Hintz RL, Gesundheit N, Marcus R. 1994 Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women. J Clin Endocrinol Metab. 79:470-479.
36. Marcus R, Butterfield G, Holloway L, et al. 1990 Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab. 70:519-527.
37. Rudman D, Feller AG, Nagraj HS, et al. 1990 Effects of human growth hormone in men over 60 years old. N Engl J Med. 323:1-6.