Expression of heat shock protein 27 and alpha-crystallins in human retinoblastoma after chemoreduction

British Journal of Ophthalmology

Volumn 93, Issue 4, 2009, Pages 541-544

  Kase, S ^a   Parikh, J G ^a   Rao, N A ^a,b  

^a DOHENY EYE INSTITUTE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; ALPHA CRYSTALLIN ANTIBODY; CARBOPLATIN; ETOPOSIDE; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 27 ANTIBODY; PROTEIN ANTIBODY; SMALL HEAT SHOCK PROTEIN; UNCLASSIFIED DRUG; VINCRISTINE SULFATE;

ARTICLE; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENUCLEATION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFANT; MALE; PREOPERATIVE CARE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINOBLASTOMA;

ALPHA-CRYSTALLINS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHILD, PRESCHOOL; EYE ENUCLEATION; FEMALE; HSP27 HEAT-SHOCK PROTEINS; HUMANS; INFANT; MALE; NEOADJUVANT THERAPY; NEOPLASM PROTEINS; RETINAL NEOPLASMS; RETINOBLASTOMA;

EID: 64849112707     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjo.2008.145508     Document Type: Article

References (25)

1. Arrigo AP, Simon S, Gibert B, et al. Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets. FEBS Lett 2007;581:3665-74.
2. Mehlen P, Schulze-Osthoff K, Arrigo AP. Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1-and staurosporine-induced cell death. J Biol Chem 199;271:16510-14.
3. Concannon CG, Gorman AM, Samali A. On the role of Hsp27 in regulating apoptosis. Apoptosis 2003;8:61-70.
4. Kamradt MC, Chen F, Sam S, et al. The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. J Biol Chem 2002;277:38731-6.
5. Kamradt MC, Chen F, Cryns VL. The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation. J Biol Chem 2001;276:16059-63.
6. Kamradt MC, Lu M, Werner ME, et al. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. J Biol Chem 2005;280: 11059-66.
7. Rao IMA, Saraswathy S, Wu GS, et al. Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis. Invest Ophthalmol Vis Sci 2008;49:1161-71.
8. Hitotsumatsu T, Iwaki T, Fukui M, et al. Distinctive immunohistochemical profiles of small heat shock proteins (heat shock protein 27 and alpha B-crystallin) in human brain tumors. Cancer 1996;77:352-61.
9. Ivanov O, Chen F, Wiley EL, et al. AlphaB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer. Breast Cancer Res Treat 2008;111:411-17.
10. Moyano JV, Evans JR, Chen F, et al. AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer. J Clin Invest 2006;116:261-70.
11. Chin D, Boyle GM, Williams RM, et al. Alpha B-crystallin, a new independent marker for poor prognosis in head and neck cancer. Laryngoscope 2005;115:1239-42.
12. Mineva I, Gartner W, Hauser P, et al. Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing. Cell Stress Chaperones 2005;10:171-84.
13. Romani AA, Crafa P, Desenzani S, et al. The expression of HSP27 is associated with poor clinical outcome in intrahepatic cholangiocarcinoma. BMC Cancer 2007;7:232.
14. Suzuki H, Sugimura H, Hashimoto K. Overexpression of heat shock protein 27 is associated with good prognosis in the patient with oral squamous cell carcinoma. Br J Oral Maxillofac Surg 2007;45:123-9.
15. Chan HS, Gallie BL, Munier FL, et al. Chemotherapy for retinoblastoma. Ophthalmol Clin North Am 2005;18:55-63, viii.
16. Murphree AL, Villablanca JG, Deegan WF 3rd, et al. Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch Ophthalmol 1996;114:1348-56.
17. Oesterreich S, Weng CN, Qiu M, et al. The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res 1993;53:4443-8.
18. Rocchi P, So A, Kojima S, et al. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res 2004;64:6595-602.
19. Andley UP, Song Z, Wawrousek EF, et al. Differential protective activity of alpha A- and alphaB-crystallin in lens epithelial cells. J Biol Chem 2000;275:36823-31.
20. Mao YW, Liu JP, Xiang H, et al. Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis. Cell Death Differ 2004;11:512-26.
21. Liu JP, Schlosser R, Ma WY, et al. Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. Exp Eye Res 2004;79:393- 403.
22. Andley UP. Crystallins in the eye: Function and pathology. Prog Retin Eye Res 2007;26:78-98.
23. Garrido C, Bruey JM, Fromentin A, et al. HSP27 inhibits cytochrome c-dependent activation of procaspase-9. FASEB J 1999;13:2061-70.
24. Paul C, Manero F, Gonin S, et al. Hsp27 as a negative regulator of cytochrome C release. Mol Cell Biol 2002;22:816-34.
25. Zhang Y, Shen X. Heat shock protein 27 protects L929 cells from cisplatin-induced apoptosis by enhancing Akt activation and abating suppression of thioredoxin reductase activity. Clin Cancer Res 2007;13:2855- 64.