Is there a role for insulin resistance in nonobese patients with idiopathic hirsutism?

British Journal of Dermatology

Volumn 160, Issue 5, 2009, Pages 1011-1015

  Fattah, Nermeen S A Abdel ^a   Darwish, Y W ^a  

^a AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

Homeostasis model assessment of insulin resistance; Idiopathic hirsutism; Insulin resistance

Indexed keywords

INSULIN;

ADULT; ARTICLE; BODY MASS; CASE CONTROL STUDY; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIET RESTRICTION; DISEASE ASSOCIATION; FEMALE; GROUPS BY AGE; HIRSUTISM; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; OBESITY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; WAIST HIP RATIO;

BODY MASS INDEX; CASE-CONTROL STUDIES; FASTING; FEMALE; HIRSUTISM; HUMANS; INSULIN; INSULIN RESISTANCE; OBESITY; POLYCYSTIC OVARY SYNDROME; YOUNG ADULT;

EID: 64849104179     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09078.x     Document Type: Article

References (23)

1. Rosenfield R. Hirsutism. N Engl J Med 2005 353 : 2578 88.
2. Azziz R, Carmina E, Sawaya M. Idiopathic hirsutism. Endocr Rev 2000 21 : 347 62.
3. Escobar-Morreale H, Serrano-Gotarredona J, Garcia-Robles R. Abnormalities in the serum insulin-like growth factor-1 axis in women with hyperandrogenism. Fertil Steril 1998 70 : 1090 100.
4. McAuley K, William S, Mann J. Diagnosing insulin resistance in the general population. Diabetes Care 2001 24 : 460 4.
5. Mehmet K, Selim K, Mustafa K et al. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005 115 : 500 3.
6. Knochenhauer ES, Key TJ, Kahsar-Miller M et al. Prevalence of the polycystic ovary syndrome in unselected black and white women of the south eastern United States: a prospective study. J Clin Endocrinol Metab 1998 83 : 3078 82.
7. Fauser BCJM. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004 19 : 41 7.
8. Daviglus M, Liu K, Yan L. Body mass index in middle age and health-related quality of life in older age. Arch Intern Med 2003 163 : 2448 55.
9. Dalton M, Cameron A, Zimmet P. Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults. J Intern Med 2003 254 : 555 63.
10. Sawaya M, Shalita A. Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism and acne. J Cutan Med Surg 1998 3 : 9 15.
11. Rosa M, Miryam M, José S. The role of the CAG repeat polymorphism in the androgen receptor gene and of skewed X-chromosome inactivation, in the pathogenesis of hirsutism. J Clin Endocrinol Metab 2000 85 : 1735 40.
12. Ünlühizarci K, Karababa Y, Bayram F et al. The investigation of insulin resistance in patients with idiopathic hirsutism. J Clin Endocrinol Metab 2004 89 : 2741 4.
13. Kuo J, Kumar A, Decherney AH et al. Are patients with idiopathic hirsutism (IH) insulin resistant? Comparing women with IH to body mass index-matched patients with polycystic ovary syndrome (PCOS) and controls. Fertil Steril 2004 82 (Suppl. 2 301 2.
14. Thiboutot D, Jabara S, McAllister J et al. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol 2003 120 : 905 14.
15. Pham-Huu-Trung M, Villette J, Bogyo A. Effects of insulin-like growth factor 1 (IGF-1) on enzymatic activity in human adrenocortical cells: interactions with ACTH. J Steroid Biochem Mol Biol 1991 39 : 903 9.
16. Chen W, Thiboutot D, Zouboulis C. Cutaneous androgen metabolism: basic research and clinical perspectives. J Invest Dermatol 2002 119 : 992 1007.
17. Mark C, David M, Diane T. Correlation between serum levels of insulin-like growth factor-1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women. Arch Dermatol 2005 141 : 333 8.
18. Philpott M, Sanders D, Kealey T. Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-1 at physiologic concentrations is an important regulator of hair follicle growth in vitro. J Invest Dermatol 1994 102 : 857 61.
19. Horton R, Pasupuletti V, Antonipillai I. Androgen induction of steroid 5α-reductase may be mediated via insulin-like growth factor 1. Endocrinology 1993 133 : 447 51.
20. Moore M, Park C, Tsuda H. Implications of the hyperinsulinaemia-diabetes- cancer link for preventive efforts. Eur J Cancer Prev 1998 7 : 89 107.
21. Henry N. Insulin resistance and cardiovascular disease. J Clin Invest 2000 106 : 453 8.
22. Lender D, Arauz-Pacheco C, Adams-Huet B et al. Essential hypertension is associated with decreased insulin clearance and insulin resistance. Hypertension 1997 29 : 111 14.
23. Despres JP, Lamarche B, Mauriege P. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996 334 : 952 7.