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Volumn 30, Issue 1, 2009, Pages 42-53

Dehydroepiandrosterone anti-atherogenesis effect is not via its conversion to estrogen

Author keywords

All trans retinoic acid; Athero sclerosis; Cytochrome P450 aromatase; Dehydroepiandrosterone; MCP 1; Transfection; VCAM 1

Indexed keywords

AROMATASE; ESTROGEN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PRASTERONE; RETINOIC ACID; VASCULAR CELL ADHESION MOLECULE 1; LIPID; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN;

EID: 64849088458     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2008.2     Document Type: Article
Times cited : (7)

References (41)
  • 1
    • 0344172843 scopus 로고    scopus 로고
    • Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging
    • Parker CR. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids 1999; 64: 640-7.
    • (1999) Steroids , vol.64 , pp. 640-647
    • Parker, C.R.1
  • 2
    • 0035752907 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA)-structure, clinical importance and the role in human body
    • Zdrojewicz Z, Ciszko B. Dehydroepiandrosterone (DHEA)-structure, clinical importance and the role in human body. Postepy Hig Med Dosw 2001; 55: 835-54.
    • (2001) Postepy Hig Med Dosw , vol.55 , pp. 835-854
    • Zdrojewicz, Z.1    Ciszko, B.2
  • 3
    • 0034036174 scopus 로고    scopus 로고
    • The effects of dehydroepiandrosterone on carcino-genesis, obesity, the immune system, and aging
    • Williams JR. The effects of dehydroepiandrosterone on carcino-genesis, obesity, the immune system, and aging. Lipids 2000; 35: 325-31.
    • (2000) Lipids , vol.35 , pp. 325-331
    • Williams, J.R.1
  • 4
    • 0034043204 scopus 로고    scopus 로고
    • Do DHEA/DHEAS play a protective role in coronary heart disease?
    • PorŠovÁ-dutoit I, ŠulcovÁ J, StÁrka L. Do DHEA/DHEAS play a protective role in coronary heart disease? Physiol Res 2000; 49 (Suppl 1): S43-S56.
    • (2000) Physiol Res , vol.49 , Issue.SUPPL. 1
    • PorŠovÁ-dutoit, I.1    ŠulcovÁ, J.2    StÁrka, L.3
  • 5
    • 0037396460 scopus 로고    scopus 로고
    • Androgens and coronary artery disease
    • Fredrick CWW, Arnold VE. Androgens and coronary artery disease. Endocrine Rev 2003; 24: 183-217.
    • (2003) Endocrine Rev , vol.24 , pp. 183-217
    • Fredrick, C.W.W.1    Arnold, V.E.2
  • 7
    • 0036242917 scopus 로고    scopus 로고
    • Androgen effects on bone and muscle
    • Notelovitz M. Androgen effects on bone and muscle. Fertil Steril 2002; 77: S34-S41.
    • (2002) Fertil Steril , vol.77
    • Notelovitz, M.1
  • 8
    • 0034103177 scopus 로고    scopus 로고
    • Dehydro-epiandrosterone retards atherosclerosis formation through its conversion to estrogen: The possible role of nitric oxide
    • Hayashi T, Muto E, Kano H, Asai Y, Takur NK, et al. Dehydro-epiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide. Arterioscler Thromb Vasc Biol 2000; 20: 782-92.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 782-792
    • Hayashi, T.1    Muto, E.2    Kano, H.3    Asai, Y.4    Takur, N.K.5
  • 9
    • 0031557110 scopus 로고    scopus 로고
    • Effects of dehydroepiandrosterone on proliferation of human aortic muscle cells
    • Yoneyama A, Kamiya Y, Kawaguchi M, Fujinami T. Effects of dehydroepiandrosterone on proliferation of human aortic muscle cells. Life Sci 1997; 60: 833-8.
    • (1997) Life Sci , vol.60 , pp. 833-838
    • Yoneyama, A.1    Kamiya, Y.2    Kawaguchi, M.3    Fujinami, T.4
  • 10
    • 0028970042 scopus 로고
    • Cell biology of atherosclerosis
    • Ross R. Cell biology of atherosclerosis. Annu Rev Physiol 1995; 57: 791-804.
    • (1995) Annu Rev Physiol , vol.57 , pp. 791-804
    • Ross, R.1
  • 11
    • 0028338558 scopus 로고
    • Involvement of adhesion molecules in human monocyte adhesion to and transmigration through endothelial cells in vitro
    • Takahashi M, Ikeda U, Masuyama J, Kitagawa S, Kasahara T, Saito M, et al. Involvement of adhesion molecules in human monocyte adhesion to and transmigration through endothelial cells in vitro. Atherosclerosis 1994; 108: 73-81.
    • (1994) Atherosclerosis , vol.108 , pp. 73-81
    • Takahashi, M.1    Ikeda, U.2    Masuyama, J.3    Kitagawa, S.4    Kasahara, T.5    Saito, M.6
  • 12
    • 0026497181 scopus 로고
    • Mechanisms in intimal monocyte-macrophage recruitment: A special role for monocyte chemotactic protein-1
    • III-20-III-25
    • Valente AJ, Rozek MM, Sprague EA, Schwartz CJ. Mechanisms in intimal monocyte-macrophage recruitment: a special role for monocyte chemotactic protein-1. Circulation 1992; 86 (Suppl III): III-20-III-25.
    • (1992) Circulation , vol.86 , Issue.SUPPL. III
    • Valente, A.J.1    Rozek, M.M.2    Sprague, E.A.3    Schwartz, C.J.4
  • 13
    • 0027714715 scopus 로고
    • Monocyte-endothelial interactions: Insights and questions
    • Kuijpers T W, Harlan JM. Monocyte-endothelial interactions: insights and questions. J Lab Clin Med 1993; 122: 641-51.
    • (1993) J Lab Clin Med , vol.122 , pp. 641-651
    • Kuijpers, T.W.1    Harlan, J.M.2
  • 14
    • 0033597952 scopus 로고    scopus 로고
    • Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation
    • Iivama K, Hajra L, Iiyama M, Li H, DiChiara M, Medoff BD, et al. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 1999; 85: 199-207.
    • (1999) Circ Res , vol.85 , pp. 199-207
    • Iivama, K.1    Hajra, L.2    Iiyama, M.3    Li, H.4    DiChiara, M.5    Medoff, B.D.6
  • 15
    • 0022979486 scopus 로고
    • Morphology and cell kinetics of fatty streak lesion formation in the hypercholesterolemic rabbit
    • Walker LN, Reidy MA, Bowyer DE. Morphology and cell kinetics of fatty streak lesion formation in the hypercholesterolemic rabbit. Am J Pathol 1986; 125: 450-9.
    • (1986) Am J Pathol , vol.125 , pp. 450-459
    • Walker, L.N.1    Reidy, M.A.2    Bowyer, D.E.3
  • 16
    • 0027170699 scopus 로고
    • Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate
    • Parhami F, Fang ZT, Fogelman AM, Andalibi A, Territo MC, Berliner JA. Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate. J Clin Invest 1993; 92: 471-8.
    • (1993) J Clin Invest , vol.92 , pp. 471-478
    • Parhami, F.1    Fang, Z.T.2    Fogelman, A.M.3    Andalibi, A.4    Territo, M.C.5    Berliner, J.A.6
  • 17
    • 0026075699 scopus 로고
    • Monocyte chemoattractant protein-1 in human atheromatous plaques
    • Nelken NA, Coughlin SR, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest 1991; 88: 1121-7.
    • (1991) J Clin Invest , vol.88 , pp. 1121-1127
    • Nelken, N.A.1    Coughlin, S.R.2    Gordon, D.3    Wilcox, J.N.4
  • 19
    • 0027971913 scopus 로고
    • Dehydroepiandrosterone induced peroxisome proliferation in the rat: Evaluation of sex differences
    • Rao MS, Ide RE, Subbarao V, Reddy AJ. Dehydroepiandrosterone induced peroxisome proliferation in the rat: evaluation of sex differences. Proc Soc Exp Biol Med 1994; 20: 186-90.
    • (1994) Proc Soc Exp Biol Med , vol.20 , pp. 186-190
    • Rao, M.S.1    Ide, R.E.2    Subbarao, V.3    Reddy, A.J.4
  • 20
    • 0024603895 scopus 로고
    • Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity
    • Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320: 915-24.
    • (1989) N Engl J Med , vol.320 , pp. 915-924
    • Steinberg, D.1    Parthasarathy, S.2    Carew, T.E.3    Khoo, J.C.4    Witztum, J.L.5
  • 21
    • 0033669559 scopus 로고    scopus 로고
    • Atherosclerosis: Cell biology and lipoproteins
    • Brown AJ. Atherosclerosis: Cell biology and lipoproteins. Curr Opin Lipidol 2000; 11: 667-9.
    • (2000) Curr Opin Lipidol , vol.11 , pp. 667-669
    • Brown, A.J.1
  • 23
    • 0029555279 scopus 로고
    • The epidemiology of DHEAS and cardiovascular disease
    • Barret-Connor E, Goodman-Gruen D. The epidemiology of DHEAS and cardiovascular disease. Ann NY Acad Sci 1995; 774: 259-70.
    • (1995) Ann NY Acad Sci , vol.774 , pp. 259-270
    • Barret-Connor, E.1    Goodman-Gruen, D.2
  • 25
    • 0035749785 scopus 로고    scopus 로고
    • Adrenal C19 steroids and lipoprotein levels in healthy men
    • Vatalas IA, Diony-Asteriou A. Adrenal C19 steroids and lipoprotein levels in healthy men. Nutr Metab Cardiovasc Dis 2001; 1: 388-93.
    • (2001) Nutr Metab Cardiovasc Dis , vol.1 , pp. 388-393
    • Vatalas, I.A.1    Diony-Asteriou, A.2
  • 26
    • 17744398857 scopus 로고    scopus 로고
    • The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in pro-portion to the severity
    • Moriyama Y, Yasue H, Yoshimura M, Mizuno Y, Nishiyama K, Tsunoda R, et al. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in pro-portion to the severity. J Clin Endocrinol Metab 2000; 85: 1834- 40.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1834-1840
    • Moriyama, Y.1    Yasue, H.2    Yoshimura, M.3    Mizuno, Y.4    Nishiyama, K.5    Tsunoda, R.6
  • 27
    • 14944383935 scopus 로고    scopus 로고
    • Different effect of hormone replacement therapy, DHEAS and tibolone on endothelial function in postmenopausal women with increased cardiovascular risk
    • Silvestri A, Gambacciani M, Vitale C, Monteleone P, Ciaponi M, Fini M, et al. Different effect of hormone replacement therapy, DHEAS and tibolone on endothelial function in postmenopausal women with increased cardiovascular risk. Maturitas 2005; 50: 305-11.
    • (2005) Maturitas , vol.50 , pp. 305-311
    • Silvestri, A.1    Gambacciani, M.2    Vitale, C.3    Monteleone, P.4    Ciaponi, M.5    Fini, M.6
  • 28
    • 0034999978 scopus 로고    scopus 로고
    • Dehydroepiandrosterone replacement in women with adrenal insufficiency: Effects on body composition, serum leptin, bone turnover, and exercise capacity
    • Callies F, Fassnacht M, van Vlijmen JC, Koehler I, Huebler D, Seibel MJ, et al. Dehydroepiandrosterone replacement in women with adrenal insufficiency: effects on body composition, serum leptin, bone turnover, and exercise capacity. J Clin Endocrinol Metab 2001; 86: 1968-72.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1968-1972
    • Callies, F.1    Fassnacht, M.2    van Vlijmen, J.C.3    Koehler, I.4    Huebler, D.5    Seibel, M.J.6
  • 29
    • 0034103177 scopus 로고    scopus 로고
    • Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: The possible role of nitric oxide
    • Hayashi T, Esaki T, Muto E, Kano H, Asai Y, Thakur NK, et al. Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: The possible role of nitric oxide. Arterioscler Thromb Vasc Biol 2000; 20: 782-92.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 782-792
    • Hayashi, T.1    Esaki, T.2    Muto, E.3    Kano, H.4    Asai, Y.5    Thakur, N.K.6
  • 30
    • 0034833604 scopus 로고    scopus 로고
    • Expression of the rabbit cyto-chrome P450 aromatase encoding gene uses alternative tissuespecifc promoters
    • Bouraima H, Hanoux V, Mitre H. Expression of the rabbit cyto-chrome P450 aromatase encoding gene uses alternative tissuespecifc promoters. Eur J Biochem 2001; 268: 4506-12.
    • (2001) Eur J Biochem , vol.268 , pp. 4506-4512
    • Bouraima, H.1    Hanoux, V.2    Mitre, H.3
  • 31
    • 0031792594 scopus 로고    scopus 로고
    • Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6
    • Shozu M, Zhao Y, Bulun SE, Simpson ER. Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6. Endocrinology 1998; 139: 1610-7.
    • (1998) Endocrinology , vol.139 , pp. 1610-1617
    • Shozu, M.1    Zhao, Y.2    Bulun, S.E.3    Simpson, E.R.4
  • 32
    • 0242692988 scopus 로고    scopus 로고
    • Chen J, He B, Zheng D, Zhang S, Liu J, Zhu S. All-trans retinoic acid reduces intimal thickening after balloon angioplasty in atherosclerotic rabbits. Chin Med J (Engl) 1999; 112: 121-3.
    • Chen J, He B, Zheng D, Zhang S, Liu J, Zhu S. All-trans retinoic acid reduces intimal thickening after balloon angioplasty in atherosclerotic rabbits. Chin Med J (Engl) 1999; 112: 121-3.
  • 33
    • 13844305793 scopus 로고    scopus 로고
    • Maiti S, Chen X, Chen G. All-trans retinoic acid induction of sulfotransferases. Basic Clin Pharmacol Toxicol 2005; 96: 44-53.
    • Maiti S, Chen X, Chen G. All-trans retinoic acid induction of sulfotransferases. Basic Clin Pharmacol Toxicol 2005; 96: 44-53.
  • 34
    • 67249155299 scopus 로고    scopus 로고
    • Liu D, Dillon JS. Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma 386 seminars in reproductive medicine/22, number 4 2004 membrane receptor coupled to Galpha(i2,3). J Biol Chem 2002; 277: 21 379-88.
    • Liu D, Dillon JS. Dehydroepiandrosterone activates endothelial cell nitric-oxide synthase by a specific plasma 386 seminars in reproductive medicine/volume 22, number 4 2004 membrane receptor coupled to Galpha(i2,3). J Biol Chem 2002; 277: 21 379-88.
  • 35
    • 0032570885 scopus 로고    scopus 로고
    • Inhibition of migra tion and proliferation of vascular smooth muscle cells by dehydro epiandrosterone sulfate
    • Furutama D, Fukui R, Amakawa M, Ohsawa N. Inhibition of migra tion and proliferation of vascular smooth muscle cells by dehydro epiandrosterone sulfate. Biochim Biophys Acta 1998; 1406: 107-14.
    • (1998) Biochim Biophys Acta , vol.1406 , pp. 107-114
    • Furutama, D.1    Fukui, R.2    Amakawa, M.3    Ohsawa, N.4
  • 36
    • 0042816523 scopus 로고    scopus 로고
    • Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms
    • Simoncini T, Mannella P, Fornari L, Varone G, Caruso A, Genazzani AR. Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology 2003; 144: 3449-55.
    • (2003) Endocrinology , vol.144 , pp. 3449-3455
    • Simoncini, T.1    Mannella, P.2    Fornari, L.3    Varone, G.4    Caruso, A.5    Genazzani, A.R.6
  • 37
    • 18244385519 scopus 로고    scopus 로고
    • Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs
    • Williams MR, Ling S, Dawood T, Hashimura K, Dai A, Li H, et al. Dehydroepiandrosterone inhibits human vascular smooth muscle cell proliferation independent of ARs and ERs. J Clin Endocrinol Metab 2002; 87: 176-81.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 176-181
    • Williams, M.R.1    Ling, S.2    Dawood, T.3    Hashimura, K.4    Dai, A.5    Li, H.6
  • 38
    • 15944363029 scopus 로고    scopus 로고
    • Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen- and estrogenreceptor independent
    • Zapata E, Ventura JL, De la Cruz K, Rodriguez E, Damián P, Massó F, et al. Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen- and estrogenreceptor independent. FEBS J 2005; 272: 1343-53.
    • (2005) FEBS J , vol.272 , pp. 1343-1353
    • Zapata, E.1    Ventura, J.L.2    De la Cruz, K.3    Rodriguez, E.4    Damián, P.5    Massó, F.6
  • 39
    • 0027162602 scopus 로고
    • Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative
    • Daynes R, Araneo BA, Ershler WB, Maloney C, Li GZ, Ryu SY. Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J Immunol 1993; 150: 5219-30.
    • (1993) J Immunol , vol.150 , pp. 5219-5230
    • Daynes, R.1    Araneo, B.A.2    Ershler, W.B.3    Maloney, C.4    Li, G.Z.5    Ryu, S.Y.6
  • 40
    • 0029998281 scopus 로고    scopus 로고
    • Dysre-gulation of IL-10 production with aging: Possible linkage to the age-associated decline in DHEA and its sulfated derivative
    • Spencer NF, Norton SD, Harrison LL, Li GZ, Daynes R. Dysre-gulation of IL-10 production with aging: possible linkage to the age-associated decline in DHEA and its sulfated derivative. Exp Gerontol 1996; 31: 393-408.
    • (1996) Exp Gerontol , vol.31 , pp. 393-408
    • Spencer, N.F.1    Norton, S.D.2    Harrison, L.L.3    Li, G.Z.4    Daynes, R.5
  • 41
    • 33845573597 scopus 로고    scopus 로고
    • Gutiérrez G, Zapata E, Montiel A, Reyes E, Montañ;o LF, et al. Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells. Atherosclerosis 2007; 190: 90-9.
    • Gutiérrez G, Zapata E, Montiel A, Reyes E, Montañ;o LF, et al. Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells. Atherosclerosis 2007; 190: 90-9.


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