Physicochemical characterization, in vitro, and in vivo evaluation of indomethacin-loaded nanocarriers self-assembled by amphiphilic polyphosphazene

Journal of Biomedical Materials Research - Part A

Volumn 86, Issue 4, 2008, Pages 914-925

  Jian, Xiang Zhang ^a,b   Shu, Hui Li ^a   Li, Xiao Hui ^a   Qiu, Li Yan ^c   Xiao, Dong Li ^d   Xiao, Jing Li ^a   Jin, Yi ^c   Kang, Jie Zhu ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Amphiphilic polyphosphazene; Indomethacin; Local drug delivery; Micelles; Poly(N isopropylacrylamide)

Indexed keywords

ACRYLIC MONOMERS; AMIDES; BIOMATERIALS; CHEMOTHERAPY; COLLOIDS; CONCENTRATION (PROCESS); CRITICAL MICELLE CONCENTRATION; DRUG DELIVERY; DRUG DOSAGE; DRUG PRODUCTS; MICELLES; NANOSTRUCTURED MATERIALS; NANOSTRUCTURES; NANOTUBES; PLASTIC PRODUCTS; POLYMER BLENDS; POLYMERS; SOLUTIONS; VEHICLE TRANSMISSIONS;

AMPHIPHILIC; AMPHIPHILIC POLYPHOSPHAZENE; AQUEOUS SOLUTIONS; CARRAGEENAN; COMPLETE FREUND'S ADJUVANT; CRITICAL MICELLE CONCENTRATION (CMC); DRUG LOADING CAPACITY; DRUG VEHICLES; EXPERIMENTAL GROUP; GLYCINATE; HOMO POLYMERS; IN VITRO RELEASES; IN VIVO EVALUATION; IN-VITRO; IN-VIVO; INDOMETHACIN; LOCAL DELIVERY; LOCAL DRUG DELIVERY; LOWER CRITICAL SOLUTION TEMPERATURE; MORPHOLOGICAL TRANSFORMATIONS; NANOCARRIERS; NANOCONTAINERS; ORAL ADMINISTRATION; PH-DEPENDENT; PHARMACOKINETIC STUDIES; PHYSICO-CHEMICAL CHARACTERISTICS; PHYSICO-CHEMICAL CHARACTERIZATION; POLY(N-ISOPROPYLACRYLAMIDE); POLYPHOSPHAZENE; RAT PLASMAS; RELEASE PROFILES; SELF-ASSEMBLED; SPHERICAL NANOPARTICLES; SUSTAINED RELEASE; TRANSMISSION ELECTRON MICROSCOPY (TEM);

PLASMA DIAGNOSTICS;

DRUG VEHICLE; FREUND ADJUVANT; GLYCINE ETHYL ESTER; INDOMETACIN; NANOCARRIER; POLY(N ISOPROPYLACRYLAMIDE);

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFICACY; HEAT SENSITIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICELLE; NONHUMAN; PAW EDEMA; PHARMACODYNAMICS; PHYSICAL CHEMISTRY; RAT; SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY;

ACRYLAMIDES; ANIMALS; ARTHRITIS; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; EDEMA; FREUND'S ADJUVANT; GLYCINE; HYDROGEN-ION CONCENTRATION; INDOMETHACIN; MALE; MICELLES; NANOPARTICLES; ORGANOPHOSPHORUS COMPOUNDS; OSMOLAR CONCENTRATION; PARTICLE SIZE; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SPECTRUM ANALYSIS; TEMPERATURE; TIME FACTORS;

EID: 50149093853     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31560     Document Type: Article

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