Encapsulation of lipophilic drugs within enteric microparticles by a novel coacervation method

International Journal of Pharmaceutics

Volumn 326, Issue 1-2, 2006, Pages 128-138

  Dong, W ^a   Bodmeier, R ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Coacervation; Enteric polymer; Lipophilic drugs; Microencapsulation

Indexed keywords

CARBAMAZEPINE; CELLACEFATE; CYCLOSPORIN A; ESTRADIOL; EUDRAGIT; HYDROXYETHYLCELLULOSE; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; IBUPROFEN; INDOMETACIN; LIDOCAINE; POLOXAMER; POLYMER; POLYVINYL ALCOHOL;

AQUEOUS SOLUTION; ARTICLE; COACERVATION; CONCENTRATION RESPONSE; DISSOLUTION; DRUG SOLUBILITY; DRUG STABILITY; ENTERIC COATED TABLET; HYDROPHILICITY; LIPOPHILICITY; MICROENCAPSULATION; PARTICLE SIZE; PARTITION COEFFICIENT; PH; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; CARBAMAZEPINE; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; ETHANOL; HYDROGEN-ION CONCENTRATION; IBUPROFEN; MICROSPHERES; POLOXAMER; POLYMERS; SOLUBILITY; SOLVENTS; TABLETS, ENTERIC-COATED;

EID: 33750451927     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.07.013     Document Type: Article

References (25)

1. Alavi A.K., Squillante III E., and Mehta K.A. Formulation of enterosoluble microparticles for an acid labile protein. J. Pharm. Pharm. Sci. 5 (2002) 234-244
2. Amorim M.J., and Ferreira J.P. Microparticles for delivering therapeutic peptides and proteins to the lumen of the small intestine. Eur. J. Pharm. Sci. 52 (2001) 39-44
3. Arangoa M.A., Campanero M.A., Renedo M.J., Ponchel G., and Irache J.M. Gliadin nanoparticles as carriers for the oral administration of lipophilic drugs. Relationships between bioadhesion and pharmacokinetics. Pharm. Res. 18 (2001) 1521-1527
4. Barton A.F.M. Handbook of Solubility Parameters and Other Cohesion Parameters (1983), CRC Press, Boca Raton, FL, USA 172, 281, 142-146
5. CDER, Guidance for Industry Q3C Impurities: Residual Solvents. http://www.fda.gov/cder/guidance/Q3Cfinal.htm.
6. De Jaeghere F., Allemann E., Kubel F., Galli B., Cozen R., Doelker E., and Gurny R. Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles: effect of the particle size and nutritional state. J. Control. Release 68 (2000) 229-291
7. De Jaeghere F., Allémann E., Cerny R., Galli B., Steulet A.F., Müller I., Schütz H., Doelker E., and Gurry R. pH-dependent dissolving nano- and microparticles for improved peroral delivery of a highly lipophilic compound in dogs. AAPS Pharmsci. 3 1 (2001). http://www.pharmsci.org/ article 8 (http://www.pharmsci.org/)
8. Deasy P.B. Microencapsulation and Related Drug Processes. Drugs and the Pharmaceutical Sciences vol. 20 (1984), Marcel Dekker, Inc., New York and Basel 76-77; 107-109
9. Dollo G., Le Corre P., Guerin A., Chevanne F., Burgot J.L., and Leverge R. Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs. Eur. J. Pharm. Sci. 19 (2003) 273-280
10. Fessi H., Puisieux F., Devissaguet J.Ph., Ammoury N., and Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int. J. Pharm. 55 (1989) R1-R4
11. Galindo-Rodriguez, S.A., 2004. Etude comparative de trios techniques de préparation de nanoparticules á base de polyméres: Physico-chimie, efficacité d'encapsulation et transposition d'échelle. Ph.D Thesis, University of Geneva, Switzerland.
12. Galindo-Rodriguez S.A., Allemann E., Fessi H., and Doelker E. Physicochemical parameters associated with nanoparticle formulation in the salting-out, emulsification-diffusion, and nanoprecipitation methods. Pharm. Res. 21 (2004) 1428-1439
13. Kislalioglu M.S., Khan M.A., Blount C., Goettsch R.W., and Bolton S. Physical characterization and dissolution properties of ibuprofen: eudragit coprecipitates. J. Pharm. Sci. 80 (1991) 799-804
14. Lamprecht A., Yamamoto H., Takeuchi H., and Kawashima Y. Design of pH-sensitive microspheres for the colonic delivery of the immunosuppressive drug tacrolimus. Eur. J. Pharm. Biopharm. 58 (2004) 37-43
15. Lee J.H., Park T.G., and Choi H.K. Development of oral drug delivery system using floating microspheres. J. Microencapsul. 16 (1999) 715-729
16. Lerk, C.F., 1987. Topics in Pharmaceutical Sciences. In: Breimer, D.D., Speiser, P. (Eds.). Federation Internationale Pharmaceutique (F.I.P.): The Netherlands, 195-209.
17. Leroux J.C., Cozens R., Roesel J.L., Galli B., Kubel F., Doelker E., and Gurny R. Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice. J. Pharm. Sci. 84 (1995) 1387-1391
18. Leroux J.C., Cozens R., Roesel J.L., Galli B., Doelker E., and Gurny R. pH-sensitive nanoparticles: an effective means to improve the oral delivery of HIV-1 protease inhibitors in dogs. Pharm. Res. 13 (1996) 485-487
19. Mei T., and Burgess D.J. Preparation and stabilization of heparin/gelatin complex coacervate. J. Pharm. Sci. 86 (1997) 603-607
20. Nazzal S., Guven N., Reddy I.K., and Khan M.A. Preparation and characterization of coenzyme Q10-Eudragit solid dispersion. Drug Dev. Ind. Pharm. 28 (2002) 49-57
21. Paradkar A., Ambike A.A., Jadhav B.K., and Mahadik K.R. Characterization of curcumin-PVP solid dispersion obtained by spray drying. Int. J. Pharm. 271 (2004) 281-286
22. Pinnamaneni S., Das N.G., and Das S.K. Formulation approaches for orally administered poorly soluble drugs. Pharmazie 57 (2002) 291-300
23. Roger T.L., Nelsen A.C., Sarkari M., Young T., Johnston K.P., and Williams R.O. Enhanced aqueous dissolution of a poorly water soluble drug by novel particle engineering technology: spray-freezing into liquid with atmosphere freeze-drying. Pharm. Res. 20 (2003) 485-493
24. Serajuddin A.T.M. Solid dispersion of lipophilic drugs: early promises, subsequent problems, and recent breakthroughs. J. Pharm. Sci. 88 (1999) 1058-1066
25. Zaghloul A.A., Vaithiyalingam S.R., Faltinek J., Reddy I.K., and Khan M.A. Response surface methodology to obtain naproxen controlled release tablets from its microspheres with Eudragit L100-55. J. Microencapsul. 18 (2001) 651-662