-
1
-
-
2542615200
-
Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
-
Andre T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004; 350: 2343-51.
-
(2004)
N Engl J Med
, vol.350
, pp. 2343-2351
-
-
Andre, T.1
Boni, C.2
Mounedji-Boudiaf, L.3
-
2
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan study group
-
Saltz LB, Cox JV, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan study group. N Engl J Med 2000; 343: 905-14.
-
(2000)
N Engl J Med
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
-
3
-
-
0034712536
-
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
-
Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000; 355: 1041-7.
-
(2000)
Lancet
, vol.355
, pp. 1041-1047
-
-
Douillard, J.Y.1
Cunningham, D.2
Roth, A.D.3
-
4
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
De Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18: 2938-47.
-
(2000)
J Clin Oncol
, vol.18
, pp. 2938-2947
-
-
De Gramont, A.1
Figer, A.2
Seymour, M.3
-
5
-
-
1842569206
-
A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
-
Goldberg RM, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004; 22: 23-30.
-
(2004)
J Clin Oncol
, vol.22
, pp. 23-30
-
-
Goldberg, R.M.1
Sargent, D.J.2
Morton, R.F.3
-
6
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
-
Tournigand C, Andre T, Achille E, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004; 22: 229-37.
-
(2004)
J Clin Oncol
, vol.22
, pp. 229-237
-
-
Tournigand, C.1
Re, T.2
Achille, E.3
-
7
-
-
2142703727
-
Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
-
Grothey A, Sargent D, Goldberg RM, Schmoll HJ. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004; 22: 1209-14.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1209-1214
-
-
Grothey, A.1
Sargent, D.2
Goldberg, R.M.3
Schmoll, H.J.4
-
8
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-42.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
9
-
-
33750366159
-
Bevacizumab in the treatment of metastatic colorectal cancer (MCRC) in second- and third-line settings
-
Giantonio BJ. Bevacizumab in the treatment of metastatic colorectal cancer (mCRC) in second- and third-line settings. Semin Oncol 2006; 33 (suppl 10): S15-8.
-
(2006)
Semin Oncol
, vol.33
, pp. S15-SS8
-
-
Giantonio, B.J.1
-
10
-
-
0025343230
-
Signal transduction by receptors with tyrosine kinase activity
-
Ullrich A, Schlessinger J. Signal transduction by receptors with tyrosine kinase activity. Cell 1990; 61: 203- 12.
-
(1990)
Cell
, vol.61
-
-
Ullrich, A.1
Schlessinger, J.2
-
11
-
-
1842471336
-
Signaling through the epidermal growth factor receptor during the development of malignancy
-
Grandis JR, Sok JC. Signaling through the epidermal growth factor receptor during the development of malignancy. Pharmacol Ther 2004; 102: 37-46.
-
(2004)
Pharmacol Ther
, vol.102
, pp. 37-46
-
-
Grandis, J.R.1
Sok, J.C.2
-
12
-
-
19944426509
-
Impact of EGFR expression on colorectal cancer patient prognosis and survival
-
Spano JP, Lagorce C, Atlan D, et al. Impact of EGFR expression on colorectal cancer patient prognosis and survival. Ann Oncol 2005; 16: 102-8.
-
(2005)
Ann Oncol
, vol.16
, pp. 102-108
-
-
Spano, J.P.1
Lagorce, C.2
Atlan, D.3
-
13
-
-
0036251746
-
Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery
-
Lee JC, Wang ST, Chow NH, Yang HB. Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery. Eur J Cancer 2002; 38: 1065-71.
-
(2002)
Eur J Cancer
, vol.38
, pp. 1065-1071
-
-
Lee, J.C.1
Wang, S.T.2
Chow, N.H.3
Yang, H.B.4
-
14
-
-
0036849596
-
Evaluation of the epidermal growth factor receptor (EGFR) in colorectal tumours and lymph node metastases
-
McKay JA, Murray LJ, Curran S, et al. Evaluation of the epidermal growth factor receptor (EGFR) in colorectal tumours and lymph node metastases. Eur J Cancer 2002; 38: 2258-64.
-
(2002)
Eur J Cancer
, vol.38
, pp. 2258-2264
-
-
McKay, J.A.1
Murray, L.J.2
Curran, S.3
-
15
-
-
0142011609
-
Reduced survival of rectal cancer patients with increased tumor epidermal growth factor receptor levels
-
Kopp R, Rothbauer E, Mueller E, et al. Reduced survival of rectal cancer patients with increased tumor epidermal growth factor receptor levels. Dis Colon Rectum 2003; 46: 1391-9.
-
(2003)
Dis Colon Rectum
, vol.46
, pp. 1391-1399
-
-
Kopp, R.1
Rothbauer, E.2
Mueller, E.3
-
16
-
-
33646585797
-
Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery
-
Galizia G, Lieto E, Ferraraccio F, et al. Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery. Ann Surg Oncol 2006; 13: 823-35.
-
(2006)
Ann Surg Oncol
, vol.13
, pp. 823-835
-
-
Galizia, G.1
Lieto, E.2
Ferraraccio, F.3
-
17
-
-
0034947649
-
EGF mutant receptor vIII as a moleculai target in cancer therapy
-
Kuan CT, Wikstrand CJ, Bigner DD. EGF mutant receptor vIII as a moleculai target in cancer therapy. Endocr Relat Cancer 2001; 8: 83-96.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 83-96
-
-
Kuan, C.T.1
Wikstrand, C.J.2
Bigner, D.D.3
-
18
-
-
2342471392
-
Activating mutations in the epiderma growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epiderma growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-39.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
19
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
20
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from never smokers and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from never smokers and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA 2004; 101: 13306-11.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
22
-
-
0020933452
-
Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
-
Sato JD, Kawamoto T, Le AD, et al. Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol Biol Med 1983; 1: 511-29.
-
(1983)
Mol Biol Med
, vol.1
, pp. 511-529
-
-
Sato, J.D.1
Kawamoto, T.2
Le, A.D.3
-
23
-
-
0010233988
-
Le A, et al. Growth stimulation of A431 cells by epidermal growth factor: Identification of high-affinity receptors forepidermal growth factor by an anti-receptor monoclonal antibody
-
Kawamoto T, Sato JD, Le A, et al. Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci USA 1983;80: 1337-41.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 1337-1341
-
-
Kawamoto, T.1
Sato, J.D.2
-
24
-
-
20144372083
-
Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling
-
Aivado M, Spentzos D, Alterovitz G, et al. Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling. Clin Chem Lab Med 2005; 43: 133-40.
-
(2005)
Clin Chem Lab Med
, vol.43
, pp. 133-140
-
-
Aivado, M.1
Spentzos, D.2
Alterovitz, G.3
-
25
-
-
0028116305
-
Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
-
Fan Z, Lu Y, Wu X, Mendelsohn J. Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem 1994; 269: 27595-602.
-
(1994)
J Biol Chem
, vol.269
, pp. 27595-27602
-
-
Fan, Z.1
Lu, Y.2
Wu, X.3
Mendelsohn, J.4
-
26
-
-
0029776415
-
Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145
-
KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res 1996; 56: 3666-9.
-
(1996)
Cancer Res
, vol.56
, pp. 3666-3669
-
-
Peng, D.1
Fan, Z.2
Lu, Y.3
-
27
-
-
0028969852
-
Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin
-
Wu X, Fan Z, Masui H, et al. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest 1995; 95: 1897-905.
-
(1995)
J Clin Invest
, vol.95
, pp. 1897-1905
-
-
Wu, X.1
Fan, Z.2
Masui, H.3
-
28
-
-
0034038282
-
Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
-
Liu B, Fang M, Schmidt M, et al. Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer 2000; 82: 1991-9.
-
(2000)
Br J Cancer
, vol.82
, pp. 1991-1999
-
-
Liu, B.1
Fang, M.2
Schmidt, M.3
-
29
-
-
33646199298
-
Angiogenesis modifications related with cetuximab plus irinotecan as anticancer treatment in advanced colorectal cancer patients
-
Vincenzi B, Santini D, Russo A, et al. Angiogenesis modifications related with cetuximab plus irinotecan as anticancer treatment in advanced colorectal cancer patients. Ann Oncol 2006; 17: 835-41.
-
(2006)
Ann Oncol
, vol.17
, pp. 835-841
-
-
Vincenzi, B.1
Santini, D.2
Russo, A.3
-
30
-
-
0032972944
-
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
-
Perrotte P, Matsumoto T, Inoue K, et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 1999; 5: 257-64.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 257-264
-
-
Perrotte, P.1
Matsumoto, T.2
Inoue, K.3
-
31
-
-
0034652487
-
Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells
-
O-Charoenrat P, Modjtahedi H, Rhys-Evans P, et al. Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells. Cancer Res 2000; 60: 1121-8.
-
(2000)
Cancer Res
, vol.60
, pp. 1121-1128
-
-
O-Charoenrat, P.1
Modjtahedi, H.2
Rhys-Evans, P.3
-
32
-
-
0024261027
-
Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice
-
Aboud-Pirak E, Hurwitz E, Pirak ME, et al. Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. J Natl Cancer Inst 1988; 80: 1605-11.
-
(1988)
J Natl Cancer Inst
, vol.80
, pp. 1605-1611
-
-
Aboud-Pirak, E.1
Hurwitz, E.2
Pirak, M.E.3
-
33
-
-
0027290650
-
Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
-
Baselga J, Norton L, Masui H, et al. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst 1993; 85: 1327-33.
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 1327-1333
-
-
Baselga, J.1
Norton, L.2
Masui, H.3
-
34
-
-
0027428571
-
Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
-
Fan Z, Baselga J, Masui H, Mendelsohn J. Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res 1993; 53: 4637-42.
-
(1993)
Cancer Res
, vol.53
, pp. 4637-4642
-
-
Fan, Z.1
Baselga, J.2
Masui, H.3
Mendelsohn, J.4
-
35
-
-
0036094194
-
Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
-
Prewett MC, Hooper AT, Bassi R, et al. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res 2002; 8: 994-1003.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 994-1003
-
-
Prewett, M.C.1
Hooper, A.T.2
Bassi, R.3
-
36
-
-
0027442527
-
Therapeutic potential of chimeric and murine anti-(Epidermal growth factor receptor) antibodies in a metastasis model for human melanoma
-
Naramura M, Gillies SD, Mendelsohn J, et al. Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma. Cancer Immunol Immunother 1993; 37: 343-9.
-
(1993)
Cancer Immunol Immunother
, vol.37
, pp. 343-349
-
-
Naramura, M.1
Gillies, S.D.2
Mendelsohn, J.3
-
37
-
-
19244366949
-
Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
-
Baselga J, Pfister D, Cooper MR, et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 2000; 18: 904-14.
-
(2000)
J Clin Oncol
, vol.18
, pp. 904-914
-
-
Baselga, J.1
Pfister, D.2
Cooper, M.R.3
-
38
-
-
0034895886
-
Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer
-
Shin DM, Donato NJ, Perez-Soler R, et al. Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin Cancer Res 2001; 7: 1204-13.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1204-1213
-
-
Shin, D.M.1
Donato, N.J.2
Perez-Soler, R.3
-
39
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ Sr, et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22: 1201-8.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer, P.J.3
-
40
-
-
33750615769
-
Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
-
Lenz HJ, Van Cutsem E, Khambata-Ford S, et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J Clin Oncol 2006; 24: 4914-21.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4914-4921
-
-
Lenz, H.J.1
Van Cutsem, E.2
Khambata-Ford, S.3
-
41
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-45.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
42
-
-
33847261015
-
Phase II trial of capecitabine and oxaliplatin (CAPOX) plus cetuximab in patients with metastatic colorectal cancer who progressed after oxaliplatin-based chemotherapy
-
Souglakos J, Kalykaki A, Vamvakas L, et al. Phase II trial of capecitabine and oxaliplatin (CAPOX) plus cetuximab in patients with metastatic colorectal cancer who progressed after oxaliplatin-based chemotherapy. Ann Oncol 2006; 18: 305-10.
-
(2006)
Ann Oncol
, vol.18
, pp. 305-310
-
-
Souglakos, J.1
Kalykaki, A.2
Vamvakas, L.3
-
43
-
-
33644697486
-
Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma
-
Folprecht G, Lutz MP, Schoffski P, et al. Cetuximab and irinotecan/5-fluorouracil/folinic acid is a safe combination for the first-line treatment of patients with epidermal growth factor receptor expressing metastatic colorectal carcinoma. Ann Oncol 2006; 17: 450-6.
-
(2006)
Ann Oncol
, vol.17
, pp. 450-456
-
-
Folprecht, G.1
Lutz, M.P.2
Schoffski, P.3
-
44
-
-
33749847753
-
Challenges in the use of epidermal growth factor receptor inhibitors in colorectal cancer
-
Van Cutsem E. Challenges in the use of epidermal growth factor receptor inhibitors in colorectal cancer. Oncologist 2006; 11: 1010-7.
-
(2006)
Oncologist
, vol.11
, pp. 1010-1017
-
-
Van Cutsem, E.1
-
45
-
-
12444330870
-
A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients
-
Daneshmand M, Parolin DAE, Hirte HW, et al. A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients. Clin Cancer Res 2003; 9: 2457-64.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2457-2464
-
-
Daneshmand, M.1
Parolin, D.2
Hirte, H.W.3
-
46
-
-
33646579106
-
Phase I study of gefitinib, oxaliplatin, 5-fluorouracil, andleucovorin (IFOX) in patients with advanced solid malignancies
-
Cho CD, Fisher GA, Halsey J, Sikic BI. Phase I study of gefitinib, oxaliplatin, 5-fluorouracil, and leucovorin (IFOX) in patients with advanced solid malignancies. Invest New Drugs 2006; 24: 117-23.
-
(2006)
Invest New Drugs
, vol.24
, pp. 117-123
-
-
Cho, C.D.1
Fisher, G.A.2
Halsey, J.3
Sikic, B.I.4
-
47
-
-
23244446134
-
Phase I/II trial of gefitinib and oxaliplatin in patientswith advanced colorectal cancer
-
Kindler HL, Friberg G, Skoog L, et al. Phase I/II trial of gefitinib and oxaliplatin in patients with advanced colorectal cancer. Am J Clin Oncol 2005; 28: 340-4.
-
(2005)
Am J Clin Oncol
, vol.28
, pp. 340-344
-
-
Kindler, H.L.1
Friberg, G.2
Skoog, L.3
-
48
-
-
33644822287
-
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma
-
Rothenberg ML, LaFleur B, Levy DE, et al. Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J Clin Oncol 2005; 23: 9265-74.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9265-9274
-
-
Rothenberg, M.L.1
Lafleur, B.2
Levy, D.E.3
-
49
-
-
33644848522
-
Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: Phase I trial results
-
Czito BG, Willett CG, Bendell JC, et al. Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results. J Clin Oncol 2006; 24: 656-62.
-
(2006)
J Clin Oncol
, vol.24
, pp. 656-662
-
-
Czito, B.G.1
Willett, C.G.2
Bendell, J.C.3
-
50
-
-
33750155908
-
Phase I study of gefitinib plus FOLFIRI in previously untreated patients with metastatic colorectal cancer
-
Wolpin BM, Clark JW, Meyerhardt JA, et al. Phase I study of gefitinib plus FOLFIRI in previously untreated patients with metastatic colorectal cancer. Clin Colorectal Cancer 2006; 6: 208-13.
-
(2006)
Clin Colorectal Cancer
, vol.6
, pp. 208-213
-
-
Wolpin, B.M.1
Clark, J.W.2
Meyerhardt, J.A.3
-
51
-
-
5144223438
-
Phase I trial of irinotecan, infusional 5-fluorouracil, and leucovorin (FOLFIRI) with erlotinib (OSI-774): Early termination due to increased toxicities
-
Messersmith WA, Laheru DA, Senzer NN, et al. Phase I trial of irinotecan, infusional 5-fluorouracil, and leucovorin (FOLFIRI) with erlotinib (OSI-774): early termination due to increased toxicities. Clin Cancer Res 2004; 10: 6522-7.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6522-6527
-
-
Messersmith, W.A.1
Laheru, D.A.2
Senzer, N.N.3
-
52
-
-
33646143020
-
Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
-
Townsley CA, Major P, Siu LL, et al. Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer. Br J Cancer 2006; 94: 1136-43.
-
(2006)
Br J Cancer
, vol.94
, pp. 1136-1143
-
-
Townsley, C.A.1
Major, P.2
Siu, L.L.3
-
53
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung KY, Shia J, Kemeny NE, et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005; 23: 1803-10.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
-
54
-
-
33748146468
-
Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer
-
Hebbar MA, Wacrenier AB, Desauw CA, et al. Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer. Anticancer Drugs 2006; 17: 855-7.
-
(2006)
Anticancer Drugs
, vol.17
, pp. 855-857
-
-
Hebbar, M.A.1
Wacrenier, A.B.2
Desauw, C.A.3
-
55
-
-
34548258303
-
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
-
Sartore-Bianchi A, Moroni M, Veronese S, et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J Clin Oncol 2007; 25: 3238-45.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3238-3245
-
-
Sartore-Bianchi, A.1
Moroni, M.2
Veronese, S.3
-
56
-
-
20444498630
-
Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non-Small-Cell Lung Cancer
-
Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non-Small-Cell Lung Cancer. J. Natl. Cancer Inst 2005; 97: 643-55.
-
(2005)
J. Natl. Cancer Inst
, vol.97
, pp. 643-655
-
-
Cappuzzo, F.1
Hirsch, F.R.2
Rossi, E.3
-
57
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S, Garrett CR, Meropol NJ, et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007; 25: 3230-7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
58
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre A, Bachet JB, Le Corre D, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006; 66: 3992-5.
-
(2006)
Cancer Res
, vol.66
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
-
59
-
-
34247278727
-
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
-
Di Fiore F, Blanchard F, Charbonnier F, et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer 2007; 96: 1166-9.
-
(2007)
Br J Cancer
, vol.96
, pp. 1166-1169
-
-
Di Fiore, F.1
Blanchard, F.2
Charbonnier, F.3
-
60
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 2007; 67: 2643-8.
-
(2007)
Cancer Res
, vol.67
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
-
61
-
-
84996143042
-
-
ASCO Annual Meeting Proceedings, abstract 2
-
Van Custem E, Lang I, D’Haens G, et al. KRAS status and efficacy in fisrt-line treatment of patients with metastatic colorectal cancer (mCRC) treated with FOLFIRI with or without cetuximab: the CRYSTAL experience. ASCO Annual Meeting Proceedings 2008; vol. 26, n° 15S, Part I of II (abstract 2): 5S.
-
(2008)
KRAS Status and Efficacy in Fisrt-Line Treatment of Patients with Metastatic Colorectal Cancer (Mcrc) Treated with FOLFIRI with Or without Cetuximab: The CRYSTAL Experience
, vol.26
, Issue.15S
, pp. 5S
-
-
Van Custem, E.1
Lang, I.2
D’haens, G.3
-
62
-
-
51649120733
-
-
ASCO Annual Meeting Proceedings, abstract 4000
-
Bokemeyer C, Bondarenko I, Hartmann JT, et al. KRAS status and efficacy of fisrt-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab: the OPUS experience. ASCO Annual Meeting Proceedings 2008; vol. 26, n° 15S, Part I of II (abstract 4000): 178s.
-
(2008)
KRAS Status and Efficacy of Fisrt-Line Treatment of Patients with Metastatic Colorectal Cancer (Mcrc) with FOLFOX with Or without Cetuximab: The OPUS Experience
, vol.26
, Issue.15S
, pp. 178s
-
-
Bokemeyer, C.1
Bondarenko, I.2
Hartmann, J.T.3
-
63
-
-
55249109460
-
-
ASCO Annual Meeting Proceedings, abstract 4001
-
Tejpar S, Peeters M, Humblet Y, et al. Relastionship of efficacy with KRAS status (wild type versus mutant) in patients with irinotecan-refractory metastatic colorectal cancer (mCRC), treated with irinotecan (q2w) and escalating doses of cetuximab (qlw): the EVEREST experience (preliminary data). ASCO Annual Meeting Proceedings 2008; vol. 26, n°15S, Part I of II (abstract 4001): 178s.
-
(2008)
Relastionship of Efficacy with KRAS Status (Wild Type versus Mutant) in Patients with Irinotecan-Refractory Metastatic Colorectal Cancer (Mcrc), Treated with Irinotecan (Q2w) and Escalating Doses of Cetuximab (Qlw): The EVEREST Experience (Preliminary Data)
, vol.26
, Issue.15S
, pp. 178s
-
-
Tejpar, S.1
Peeters, M.2
Humblet, Y.3
-
64
-
-
35648941728
-
Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
-
Saltz LB, Lenz HJ, Kindler HL, et al. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study. J Clin Oncol 2007; 25: 4557-61.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4557-4561
-
-
Saltz, L.B.1
Lenz, H.J.2
Kindler, H.L.3
-
66
-
-
49149109102
-
-
ASCO Annual Meeting Proceedings, abstract LBA4011
-
Punt CJ, Tol J, Rodenburg A, et al. Randomized phase III study of capecitabine, oxaliplatin and bevacizumab with or without cetuximab in advanced colorectal cancer (ACC), the CAIRO2 study of the Dutch colorectal cancer group (DCCG). ASCO Annual Meeting Proceedings 2008; vol. 26, n° 15S, Part I of II (abstract LBA4011): 180s.
-
(2008)
Randomized Phase III Study of Capecitabine, Oxaliplatin and Bevacizumab with Or without Cetuximab in Advanced Colorectal Cancer (ACC), the CAIRO2 Study of the Dutch Colorectal Cancer Group (DCCG)
, vol.26
, Issue.15S
, pp. 180s
-
-
Punt, C.J.1
Tol, J.2
Rodenburg, A.3
|