메뉴 건너뛰기




Volumn 11, Issue 9, 2006, Pages 1010-1017

Challenges in the use of epidermal growth factor receptor inhibitors in colorectal cancer

Author keywords

Cetuximab; Epidermal growth factor receptor; Monoclonal antibody; Panitumumab; Rash; Tyrosine kinase inhibitors

Indexed keywords

BEVACIZUMAB; CANERTINIB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IRINOTECAN; MATUZUMAB; OXALIPLATIN; PANITUMUMAB; PELITINIB;

EID: 33749847753     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.11-9-1010     Document Type: Article
Times cited : (59)

References (32)
  • 1
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM et al. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004;22:1209-1214.
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3
  • 2
    • 16244379522 scopus 로고    scopus 로고
    • VEGF-targeted therapy in metastatic renal cell carcinoma
    • Rini BI. VEGF-targeted therapy in metastatic renal cell carcinoma. The Oncologist 2005;10:191-197.
    • (2005) The Oncologist , vol.10 , pp. 191-197
    • Rini, B.I.1
  • 3
    • 11244258222 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitor strategies in oncology
    • Harari PM. Epidermal growth factor receptor inhibitor strategies in oncology. Endocr Relat Cancer 2004;11:689-708.
    • (2004) Endocr Relat Cancer , vol.11 , pp. 689-708
    • Harari, P.M.1
  • 4
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor antagonists in the biology and treatment of cancer
    • Mendelsohn J, Baselga J. Status of epidermal growth factor antagonists in the biology and treatment of cancer. J Clin Oncol 2003;21:2787-2799.
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 5
    • 0032999409 scopus 로고    scopus 로고
    • Molecules in focus EGF receptor
    • Wells A. Molecules in focus EGF receptor. Int J Biochem Cell Biol 1999;31:637-643.
    • (1999) Int J Biochem Cell Biol , vol.31 , pp. 637-643
    • Wells, A.1
  • 6
    • 0344773402 scopus 로고    scopus 로고
    • The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
    • [Abstract 817]
    • Saltz L, Kies M, Abbruzzese JL et al. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc Am Soc Clin Oncol 2003;22:204. [Abstract 817].
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 204
    • Saltz, L.1    Kies, M.2    Abbruzzese, J.L.3
  • 7
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ Sr. et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004;22:1201-1208.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3
  • 8
    • 3543053772 scopus 로고    scopus 로고
    • Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin
    • [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • Lenz HJ, Mayer RJ, Gold PJ et al. Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin. J Clin Oncol 2004;22(suppl 14):3510. [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)].
    • (2004) J Clin Oncol , vol.22 , Issue.14 SUPPL. , pp. 3510
    • Lenz, H.J.1    Mayer, R.J.2    Gold, P.J.3
  • 9
    • 6344272498 scopus 로고    scopus 로고
    • ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis
    • [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • Hecht JR, Patnaik A, Malik I et al. ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): an updated analysis. J Clin Oncol 2004;22(suppl 14):3511. [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)].
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 14 , pp. 3511
    • Hecht, J.R.1    Patnaik, A.2    Malik, I.3
  • 10
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004;351:337-345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 11
    • 0001407137 scopus 로고    scopus 로고
    • Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR)
    • Rosenberg AH, Loehrer PJ, Needle MN et al. Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2002;21:536a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Rosenberg, A.H.1    Loehrer, P.J.2    Needle, M.N.3
  • 12
    • 17644389416 scopus 로고    scopus 로고
    • Cetuximab/irinotecan/high-dose-5-fluorouracil/leucovorin (HD-5-FU/LV) in the first-line therapy of metastatic colorectal cancer (CRC)
    • Folprecht G, Lutz M, Schoeffski P et al. Cetuximab/irinotecan/high-dose- 5-fluorouracil/leucovorin (HD-5-FU/LV) in the first-line therapy of metastatic colorectal cancer (CRC). 2004 Gastrointestinal Cancers Symposium. 283a.
    • 2004 Gastrointestinal Cancers Symposium
    • Folprecht, G.1    Lutz, M.2    Schoeffski, P.3
  • 13
    • 16244372110 scopus 로고    scopus 로고
    • Cetuximab+FOLFIRI as first-line treatment for metastatic colorectal CA
    • [Abstract. ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • Rougier P, Raoul J-L, Van Laethem J-L et al. Cetuximab+FOLFIRI as first-line treatment for metastatic colorectal CA. J Clin Oncol 2004;22(suppl 14):3513. [Abstract. ASCO Annual Meeting Proceedings (Post-Meeting Ed.)].
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 14 , pp. 3513
    • Rougier, P.1    Raoul, J.-L.2    Van Laethem, J.-L.3
  • 14
    • 28944440678 scopus 로고    scopus 로고
    • An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR)
    • 339a
    • Van Cutsem E, Tabernero J, Diaz-Rubio E et al. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing Epidermal Growth Factor Receptor (EGFR). Ann Oncol 2004;15(suppl 3):iii91. 339a.
    • (2004) Ann Oncol , vol.15 , Issue.SUPPL. 3
    • Van Cutsem, E.1    Tabernero, J.2    Diaz-Rubio, E.3
  • 15
    • 16244389361 scopus 로고    scopus 로고
    • A phase I/II study of cetuximab in combination with 5-fluorouracil (5-FU)/folinic acid (FA) plus weekly oxaliplatin (L-OHP) (FUFOX) in the first-line treatment of patients with metastatic colorectal cancer (mCRC) expressing epidermal growth factor receptor (EGFR): Preliminary results
    • Höhler T, Dittrich C, Lordick F, et al. A phase I/II study of cetuximab in combination with 5-fluorouracil (5-FU)/folinic acid (FA) plus weekly oxaliplatin (L-OHP) (FUFOX) in the first-line treatment of patients with metastatic colorectal cancer (mCRC) expressing epidermal growth factor receptor (EGFR): preliminary results. Ann Oncol 2004; 15(suppl 3):2620a.
    • (2004) Ann Oncol , vol.15 , Issue.SUPPL. 3
    • Höhler, T.1    Dittrich, C.2    Lordick, F.3
  • 16
    • 28444447161 scopus 로고    scopus 로고
    • Panitumumab therapy with irinotecan, 5-fluorouracil, and leucovorin (IFL) in patients (pts) with metastatic colorectal cancer (mCRC)
    • Abstract 265PD
    • Berlin J, Malik I, Picus J et al. Panitumumab therapy with irinotecan, 5-fluorouracil, and leucovorin (IFL) in patients (pts) with metastatic colorectal cancer (mCRC). Ann Oncol 2004;15 suppl 3:Abstract 265PD.
    • (2004) Ann Oncol , vol.15 , Issue.SUPPL. 3
    • Berlin, J.1    Malik, I.2    Picus, J.3
  • 17
    • 0036252329 scopus 로고    scopus 로고
    • Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model
    • Jung YD, Mansfield PF, Akagi M et al. Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model. Eur J Cancer 2002;38:1133-1140.
    • (2002) Eur J Cancer , vol.38 , pp. 1133-1140
    • Jung, Y.D.1    Mansfield, P.F.2    Akagi, M.3
  • 18
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • Ciardiello F, Bianco R, Damiano V et al. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res 2000;6:3739-3747.
    • (2000) Clin Cancer Res , vol.6 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 19
    • 21244475037 scopus 로고    scopus 로고
    • Interim report of randomized phase II trial of cetuximab/bevacizumab/ irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer
    • Abstract 169b
    • Saltz LB, Lenz H, Kindler H et al. Interim report of randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. 2005 Gastrointestinal Cancers Symposium. Abstract 169b.
    • 2005 Gastrointestinal Cancers Symposium
    • Saltz, L.B.1    Lenz, H.2    Kindler, H.3
  • 20
    • 21244475037 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer
    • Saltz LB, Lenz H, Hochster H et al. Randomized phase II trial of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. 2005 ASCO Annual Meeting. 3508a.
    • 2005 ASCO Annual Meeting
    • Saltz, L.B.1    Lenz, H.2    Hochster, H.3
  • 21
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
    • Saltz L, Rubin M, Hochster H et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2002;21:7a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Saltz, L.1    Rubin, M.2    Hochster, H.3
  • 22
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
    • Xiong HQ, Rosenberg A, LoBuglio A et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II trial. J Clin Oncol 2004;22:2610-2616.
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    LoBuglio, A.3
  • 23
    • 0003241755 scopus 로고    scopus 로고
    • Final report of the efficacy and safety of the anti-epidermal growth factor antibody Erbitux (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin containing chemotherapy
    • Kies MS, Arquette MA, Nabell L et al. Final report of the efficacy and safety of the anti-epidermal growth factor antibody Erbitux (IMC-C225), in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin containing chemotherapy. Proc Am Soc Clin Oncol 2002;21:925a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kies, M.S.1    Arquette, M.A.2    Nabell, L.3
  • 24
    • 24044555339 scopus 로고    scopus 로고
    • Correlation of acne rash and tumor response with cetuximab monotherapy in patients with colorectal cancer refractory to both irinotecan and oxaliplatin
    • 279a
    • Van Cutsem E, Mayer R, Gold P et al. Correlation of acne rash and tumor response with cetuximab monotherapy in patients with colorectal cancer refractory to both irinotecan and oxaliplatin. Eur J Cancer 2004;(suppl 2):85-86. 279a.
    • (2004) Eur J Cancer , Issue.SUPPL. 2 , pp. 85-86
    • Van Cutsem, E.1    Mayer, R.2    Gold, P.3
  • 25
    • 24044500971 scopus 로고    scopus 로고
    • Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors
    • Segaert S, Van Cutsem E. Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors. Ann Oncol 2005;16:1425-1433.
    • (2005) Ann Oncol , vol.16 , pp. 1425-1433
    • Segaert, S.1    Van Cutsem, E.2
  • 26
    • 16544377303 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: Implications for treatment with EGFR-targeted monoclonal antibodies
    • Scartozzi M, Bearzi I, Berardi R et al. Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies. J Clin Oncol 2004;22:4772-4778.
    • (2004) J Clin Oncol , vol.22 , pp. 4772-4778
    • Scartozzi, M.1    Bearzi, I.2    Berardi, R.3
  • 27
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung KY, Shia J, Kemeny NE et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J Clin Oncol 2005;23:1803-1810.
    • (2005) J Clin Oncol , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3
  • 28
    • 20144366145 scopus 로고    scopus 로고
    • A phase II trial of ZD1839 (Iressa) 750 mg per day, an oral epidermal growth factor receptor-tyrosine kinase inhibitor, in patients with metastatic colorectal cancer
    • Mackenzie MJ, Hirte HW, Glenwood G et al. A phase II trial of ZD1839 (Iressa) 750 mg per day, an oral epidermal growth factor receptor-tyrosine kinase inhibitor, in patients with metastatic colorectal cancer. Invest New Drugs 2005;23:165-170.
    • (2005) Invest New Drugs , vol.23 , pp. 165-170
    • Mackenzie, M.J.1    Hirte, H.W.2    Glenwood, G.3
  • 29
    • 11244351066 scopus 로고    scopus 로고
    • Changes in epidermal growth factor receptor signaling in serum and tumor biopsies obtained from patients with progressive metastatic colorectal cancer (MCRC) treated with gefitinib (ZD1839): An Eastern Cooperative Oncology Group study
    • [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • Rothenberg M, Lafleur B, Washington MK et al. Changes in epidermal growth factor receptor signaling in serum and tumor biopsies obtained from patients with progressive metastatic colorectal cancer (MCRC) treated with gefitinib (ZD1839): An Eastern Cooperative Oncology Group study. J Clin Oncol 2004;22(suppl 14):3000. [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)].
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 14 , pp. 3000
    • Rothenberg, M.1    Lafleur, B.2    Washington, M.K.3
  • 30
    • 33646579106 scopus 로고    scopus 로고
    • Phase I study of gefitinib, oxaliplatin, 5-fluorouracil, and leucovorin (IFOX) in patients with advanced solid malignancies
    • Jul 18:[Epub ahead of print]
    • Cho CD, Fisher GA, Halsey J et al. Phase I study of gefitinib, oxaliplatin, 5-fluorouracil, and leucovorin (IFOX) in patients with advanced solid malignancies. Invest New Drugs 2005;Jul 18:[Epub ahead of print].
    • (2005) Invest New Drugs
    • Cho, C.D.1    Fisher, G.A.2    Halsey, J.3
  • 31
    • 33749857872 scopus 로고    scopus 로고
    • Tarceva (erlotinib) in combination with Xeloda and oxaliplatin in patients with metastatic colorectal cancer (CRC). A phase I dose escalation trial
    • Van Cutsem E, Beale P, Delord J et al. Tarceva (erlotinib) in combination with Xeloda and oxaliplatin in patients with metastatic colorectal cancer (CRC). A phase I dose escalation trial. Clin Cancer Res 2003;9:109a.
    • (2003) Clin Cancer Res , vol.9
    • Van Cutsem, E.1    Beale, P.2    Delord, J.3
  • 32
    • 22744445568 scopus 로고    scopus 로고
    • Phase 1/2a study of EKB-569, an irreversible inhibitor of epidermal growth factor receptor, in combination with 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX-4) in patients with advanced colorectal cancer (CRC)
    • [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)]
    • Tejpar S, Van Cutsem E, Gamelin E et al. Phase 1/2a study of EKB-569, an irreversible inhibitor of epidermal growth factor receptor, in combination with 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX-4) in patients with advanced colorectal cancer (CRC). J Clin Oncol 2004;22(suppl 14):3579. [Abstract, ASCO Annual Meeting Proceedings (Post-Meeting Ed.)].
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 14 , pp. 3579
    • Tejpar, S.1    Van Cutsem, E.2    Gamelin, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.