Inhibition of succinic acid production in metabolically engineered Escherichia Coli by neutralizing agent, organic acids, and osmolarity

Biotechnology Progress

Volumn 25, Issue 1, 2009, Pages 116-123

  Andersson, Christian ^a   Helmerius, Jonas ^a   Hodge, David ^a   Berglund, Kris A ^a   Rova, Ulrika ^a  

^a LULEÅ UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

Cell viability; Neutralizing agent; Osmotic stress; Product inhibition; Succinic acid

Indexed keywords

CELL VIABILITY; NEUTRALIZING AGENT; OSMOTIC STRESS; PRODUCT INHIBITION; SUCCINIC ACID;

CELL CULTURE; CONCENTRATION (PROCESS); ESCHERICHIA COLI; GLUCOSE; ORGANIC ACIDS; SODIUM; SODIUM COMPOUNDS;

PRODUCTIVITY;

ESCHERICHIA COLI;

ACID; ALKALI; AMMONIUM HYDROXIDE; CARBONIC ACID DERIVATIVE; HYDROXIDE; POTASSIUM; POTASSIUM CARBONATE; POTASSIUM DERIVATIVE; POTASSIUM HYDROXIDE; SODIUM HYDROXIDE; SUCCINIC ACID;

ARTICLE; DRUG EFFECT; ESCHERICHIA COLI; FERMENTATION; GENE EXPRESSION REGULATION; GROWTH, DEVELOPMENT AND AGING; METABOLISM; OSMOLARITY;

ACIDS; ALKALIES; CARBONATES; ESCHERICHIA COLI; FERMENTATION; GENE EXPRESSION REGULATION, BACTERIAL; HYDROXIDES; OSMOLAR CONCENTRATION; POTASSIUM; POTASSIUM COMPOUNDS; SODIUM HYDROXIDE; SUCCINIC ACID;

EID: 64549148999     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1002/btpr.127     Document Type: Article

References (38)

1. Werpy T, Petersen G. Top Value Added Chemicals From Biomass, Vol. I. U.S. Department of Energy, Oak Ridge, TN. 2004.
2. Zeikus JG, Jain MK, Elankovan P. Biotechnology of succinic acid production and markets for derived industrial products. Appl Microbiol Biotechnol. 1999;51:545-552.
3. Vemuri GN, Eiteman MA, Altman E. Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli. Appl Environ Microbiol. 2002;68:1715-1727.
4. 4.Okino S, Inui M, Yukawa H. Production of organic acids by Corynebacterium glutamicum under oxygen deprivation. Appl-Microbiol Biotechnol. 2005;68:475-480.
5. Lee PC, Lee SY, Hong SH, Chang HN, Park SC. Biological conversion of wood hydrolysate to succinic acid by Anaerobio-spirillum succiniciproducens. Biotechnol Lett. 2003;25:111-114.
6. Kim DY, Yim SC, Lee PC, Lee WG, Lee SY, Chang HN.Batch and continuous fermentation of succinic acid from wood hydrolysate by Mannheimia succiniciproducens MBEL55E.Enzyme Microb Technol. 2004;35:648-653.
7. Guettler MV, Rumler D, Jain MK. Actinobacillus succinogenes sp. nov., a novel succinic-acid-producing strain from the bovine rumen. Int J Syst Bacteriol. 1999;49:207-216.
8. Lin H, Bennett GN, San KY. Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical suc-cinate yield. Metab Eng. 2005;7:116-127.
9. Sanchez AM, Bennett GN, San KY. Novel pathway engineering design of the anaerobic central metabolic pathway in Esche- richia coli to increase succinate yield and productivity. Metab Eng. 2005;7:229-239.
10. Jantama K, Haupt MJ, Svoronos SA, Zhang XL, Moore JC, Shanmugam KT, Ingram LO. Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate. Biotech- nol Bioeng. 2008;99:1140-1153.
11. Donnelly MI, Sanville-Millard CY, Nghiem NP. Method to pro-duce succinic acid from raw hydrolysates. U.S.Patent 6,743,610; 2004.
12. Andersson C, Hodge D, Berglund, KA, Rova U. Effect of dif-ferent carbon sources on the production of succinic acid using metabolically engineered Escherichia coli. Biotechnol Progr.2007;23:381-388.
13. Zaldivar J, Ingram LO. Effect of organic acids on the growth and fermentation of ethanologenic Escherichia coli LY01. Bio-technol Bioeng. 1999;66:203-210.
14. Axe DD, Bailey JE. Transport of lactate and acetate through the energized cytoplasmic membrane of Escherichia coli. Biotech-nol Bioeng. 1995;47:8-19.
15. Booth IR. Regulation of cytoplasmic pH in bacteria. Microbiol Rev. 1985;49:359-378.
16. Russell JB, DiezGonzalez F. The effects of fermentation acids on bacterial growth. Adv Microb Physiol. 1998;39:205-234.
17. Diez-Gonzalez F, Russell JB. Effects of carbonylcyanide-m- chlorophenylhydrazone (CCCP) and acetate on Escherichia coli O157:H7 and K-12: uncoupling versus anion accumulation.FEMS Microbiol Lett. 1997;151:71-76.
18. Roe AJ, O'Byrne C, McLaggan D, Booth IR. Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity.Microbiol-Sgm. 2002;148:2215-2222.
19. Underwood SA, Buszko AL, Shanmugam KT, Ingram LO. Lack of protective osmolytes limits final cell density and volumetric productivity of ethanologenic Escherichia coli KO11 during xylose fermentation. Appl Environ Microbiol. 2004;70:2734-2740.
20. Purvis JE, Yomano LP, Ingram LO. Enhanced trehalose produc-tion improves growth of Escherichia coli under osmotic stress. Appl Environ Microbiol. 2005;71:3761-3769.
21. Song H, Lee SY. Production of succinic acid by bacterial fer-mentation. Enzyme Microb Technol. 2006;39:352-361.
22. Vemuri GN, Eiteman MA, Altman E. Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions. J Ind Micro-biol Biotechnol. 2002;28:325-332.
23. Yedur S, Berglund KA, Dunuwila DD. Succinic acid production and purification. U.S. Patent 6,265,190; 2001.
24. Naundorf G, Aumen NG. Ammonia-induced cell-envelope injury in Escherichia coli and Enterobacter aerogenes. Can JMicrobiol. 1990;36:525-529.
25. + and glutamate accumulation during osmotic adaptation of Escherichia coli. J Biol Chem. 1994;269:1911-1917.
26. Ishida A, Kawatake Y, Ono N. Osmotic-stress conditioning for induction of acquired osmotolerance in Escherichia coli. J Gen Appl Microbiol. 1994;40:35-42.
27. Shiloach J, Fass R. Growing E coli to high cell density-a historical perspective on method development. Biotechnol Adv.2005;23:345- 357.
28. Gottschalk G. Bacterial Metabolism, 2nd ed. New York: Springer-Verlag; 1986.
29. Csonka LN. Physiological and genetic responses of bacteria to osmotic-stress. Microbiol Rev. 1989;53:121-147.
30. Poirier I, Marechal PA, Evrard C, Gervais P. Escherichia coli and Lactobacillus plantarum responses to osmotic stress. Appl Microbiol Biotechnol. 1998;50:704-709.
31. Cayley DS, Guttman HJ, Record MT. Biophysical characteriza-tion of changes in amounts and activity of Escherichia coli cell and compartment water and turgor pressure in response to os-motic stress. Biophys J. 2000;78:1748-1764.
32. Epstein WS. Osmoregulation by potassium transport in Esche-richia coli. FEMS Microbiol Rev. 1986;39:73-78.
33. Larsen PI, Sydnes LK, Landfald B, Str0m AR. Osmoregulation in Escherichia coli by accumulation of organic osmolytes: betaines, glutamic acid, and trehalose. Arch Microbiol. 1987; 147:1-7.
34. Giaever HM, Styrvold OB, Kaasen I, Str0m AR. Biochemical and genetic characterization of osmoregulatory trehalose synthesis in Escherichia coli. J Bacteriol. 1988;170:2841-2849.
35. Zhou S, Grabar TB, Shanmugam KT, Ingram LO, Betaine tripled the volumetric productivity of D(-)-lactate by Escherichia coli strain SZ132 in mineral salts medium. Biotechnol Lett. 2006;28:671-676.
36. Warnecke T, Gill RT. Organic acid toxicity, tolerance, and pro-duction in Escherichia coli biorefining applications. Microb Cell Fact. 2005;4:425.
37. Booth IR, Cash P, O'Byrne C. Sensing and adapting to acid stress. Antonie Van Leeuwenhoek Int J Gen Mol Microbiol. 2002;81:33-42.
38. Riesenberg D, Guthke R. High-cell-density cultivation of micro-organisms. Appl Microbiol Biotechnol. 1999;51:422-430.