Vitamin A deficiency injures liver parenchyma and alters the expression of hepatic extracellular matrix

Journal of Applied Toxicology

Volumn 29, Issue 3, 2009, Pages 214-222

  Aguilar, Rossana Pérez ^a   Genta, Susana ^a   Oliveros, Liliana ^b   Anzulovich, Ana ^b   Giménez, María Sofía ^b   Sánchez, Sara S ^a,c  

^a UNIVERSIDAD NACIONAL DE TUCUMÁN   (Argentina)

^b UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

^c Instituto Superior de Investigaciones Biologicas   (Argentina)

Author keywords

Deficiency; Extracellular matrix; Fibrosis; Liver; Vitamin a

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 4; FAT DROPLET; FIBRONECTIN; LAMININ; RETINOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXTRACELLULAR MATRIX; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINOL DEFICIENCY; STELLATE CELL; VITAMIN BLOOD LEVEL; WESTERN BLOTTING;

ACTINS; ANIMALS; COLLAGEN TYPE IV; EXTRACELLULAR MATRIX; FEMALE; FIBRONECTINS; FIBROSIS; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LAMININ; LIVER; RANDOM ALLOCATION; RATS; RATS, WISTAR; VITAMIN A DEFICIENCY;

ANIMALIA; RATTUS NORVEGICUS;

EID: 64549126520     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1399     Document Type: Article

References (61)

1. Arnaud A, Fontana L, Angulo AJ, Gil A, López Pedrosa JM. 2003. Proliferation, functionality and extracellular matrix production of hepatocytes and a liver stellate cell line. Dig. Dis. Sci. 48(7): 1406-1413.
2. Axel DI, Frigge A, Dittmann J, Runge H, Spyridopoulps I, Riessen R, Viebahn R, Karsch KR. 2001. All-frans retinoic acid regulates proliferation, migration, differentiation, and extracellular matrix turnover of human arterial smooth muscle cells. Cardiovasc. Res. 49(4): 851-862.
3. Bataller R, Brenner DA. 2005. Liver fibrosis. J. Clin. Invesf. 115: 209-218.
4. Baybutt RC, Hu L, Molteni A. 2000. Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type II pneumocytes. J. Nufr. 130: 1159-1165.
5. Bedossa P, Paradis V. 2003. Liver extracellular matrix in health and disease. J. Pafhol. 200: 504-515.
6. Bieri J, Tolliver T, Catagnani G. 1979. Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. Am. J. Clin. Nufr. 32: 2143-2149.
7. Biesalski HK, Frank J, Beck S, Heinrich F, Illek B, Reifen R, Gollnick H, Seeliger MW, Wissinger B, Zrenner E. 1999. Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinoid binding protein. Am. J. Clin. Nufr. 69: 931-936.
8. Bissell DM. 1998. Hepatic fibrosis as wound repair: a progress report. J. Gasfroenferol. 33: 295-302.
9. Blomhoff R. 1994. Introduction: Overview of vitamin A metabolism and function. In Vifamin A in Healfh and Disease, Blomhoff R (ed.). Marcel Dekker: New York; 1 -35.
10. Blomhoff R, Blomhoff HK. 2006. Overview of retinoid metabolism and function. J. Neurobiol. 66(7): 606-630.
11. Blomhoff R, Green MH, Green JB, Berg T, Norun KR. 1991. Vitamin A metabolism: new perspectives on absorption, transport and storage. Physil. Rev. 71: 951-990.
12. Clagett-Dame M, De Luca HF. 2002. The role of vitamin A in mammalian reproduction and embryonic development. Annu. Rev. Nufr. 22: 347381.
13. Clement B, Grimaud JA, Campion JP, Deugnier Y, Guillouzo A. 1986. Cell types involved in collagen and fibronectin production in normal and fibrotic human liver. Hepafology 6: 225-234.
14. Elsharkawy AM, Oakley F, Mann DA. 2005. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apopfosis 10: 927-939
15. Faraooqui AA, Antony P, Ong WY, Horrocks LA, Freysz L. 2004. Retinoic acid-mediated phospholipase A2 signaling in the nucleus. Brain. Res. Rev. 45(3): 179-195.
16. Frangieh GT, Hayashi K, Teekhasaenee C, Wolf G, Colvin RB, Gipson IK, Kenyon KR. 1989. Fibronectin and corneal epithelial wound healing in the vitamin A-deficient rat. Arch. Ophfhalmol. 107 (4): 567-571.
17. Friedman SL. 1993. The cellular basis of hepatic fibrosis. New Engl. J. Med. 28: 1828-1835.
18. Friedman SL. 1999. Cytokines and fibrogenesis. Semin. Liver Dis. 19: 129140.
19. Friedman SL. 2000. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275: 2247-2250.
20. Friedman SL, Bansal MB. 2006. Reversal of hepatic fbrosis - fact or fantasy? Hepafology 43: S82-S88. Gillis SE, Nagy LE. 1997.
21. Deposition of cellular fibronectin increases before stellate cell activation in rat liver during ethanol feeding. Alcohol Clin. Exp. Res. 21(5): 857-861.
22. Goodman DS, Blomstrand R, Werner B, Huang HS, Shiratori T. 1966. The intestinal absorption and metabolism of vitamin A and beta-carotene in man. J. Clin. Invesf. 45: 1615-1623.
23. Gressner AM. 1992. Hepatic fibrogenesis: the puzzle of interacting cells, fibrogenic cytokines, regulatory loops and extracellular matrix molecules. Z. Gasfroenfrol. 30(suppl. 1): 5-16.
24. Heifetz A, Snyder JM. 1981. The effect of hydrocortisone on the biosynthesis of sulfated glycoconjugates by human fetal lung. J. Biol. Chem. 256: 4957-4967.
25. Iredale JP. 2001. Hepatic stellate cell behavior during resolution of liver injuty. Semin. Liver Dis. 21: 427-436.
26. Kim HY, Wolf G. 1987. Vitamin A deficiency alters genomic expression for fibronectin in liver and hepatocytes. J. Biol. Chem. 262(1): 365-371. Kmiec E. 2001. Cooperation of liver cells in health and disease. Adv. Anat. Embryol. Cell Biol. 161 : 1-151.
27. Laemmli UK. 1970. Cleavage of structural protein during assembly of the head of the bacteriophage T4. Nafure 227: 680-685.
28. Leo MA, Lieber CS. 1999. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am. J. Clin. Nufr. 69(6): 1071-1085.
29. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265275.
30. Lui J, Yan J, Ma Y. 2000. Disorders of hepatic sinusoids and perisinusoidal space in chronic viral hepatitis B and its realtionship to hepatic fibrosis. Zhonghua Gan Zang Bing Za Zhi 8(4): 206-208.
31. Mann DA, Smart DE. 2002. Transcriptional regulation of hepatic stellate cell activation. Guf 50: 891-896.
32. Marfn MP, Esteban-Pretel G, Alonso R, Sado Y, Barber T, Renau-Piqueras J, Timoneda J. 2005. Vitamin A deficiency alters the structure and collagen IV composition of rat renal basement membranes. J. Nutr. 135: 695-701.
33. Martinez Hernandez A, Amenta PS. 1993. Morphology, localization and origin of the hepatic extracellular matrix. In Exfracellular Mafrix, Chemisfry, Biology and Pafhobiology wifh Emphasis on fhe Liver, Zern MA, Reid LM (eds). Marcel Dekker: New York; 201-327.
34. Matsumoto S, Yamamoto K, Nagano T, Okamoto R, Ibuki N, Tagashira M, Tsuji T. 1999. Immunohistochemical study on phenotypical changes of hepatocytes in liver disease with reference to extracellular matrix composition. Liver 19(1): 32-38.
35. Mobarhan S, Layden TJ, Friedman H, Kunigk A, Donahue PE. 1986. Depletion of liver and esophageal epithelium vitamin A after chronic moderate ethanol consumption in rats: inverse relation to zinc nutriture. Hepafology 6: 615-621.
36. National Research Council, 1985. Guide for fhe Care and Use of Laborafory Animals. Publication no. 85-23. NIH: Washington, DC.
37. Neubauer K, Kruger M, Quondamatteo F, Knittel T, Saile B, Ramadori G. 1999. Transforming growth factor-beta stimulates the synthesis of basement membrane proteins laminin, collagen type IV and entactin in rat liver sinusoidal endothelial cells. J. Hepafol. 31(4): 692-702.
38. Neubauer K, Saile B, Ramadori G. 2001. Liver fibrosis and altered matrix synthesis. Can. J. Gasfroenferol. 15(3): 187-193.
39. Oliveros LB, Domeniconi MA, Vega VA, Gatica LV, Brigada AM, Gimenez MS. 2007. Vitamin A deficiency modifies lipid metabolism in rat liver. Br. J. Nufr. 97(2): 263-272.
40. Omori M, Chytil F. 1982. Mechanism of vitamin A action. Gene expression in retinol-deficient rats. J. Biol. Chem. 257: 14370-14374.
41. Purohit V, Brenner DA. 2006. Mechanisms of alcohol induced hepatic fibrosis a summary of the Ron Thurman Symposium. Hepafology 43: 872-878.
42. Radaeva S, Wang L, Radaev S, Jcong WI, Park O, Gao B. 2007. Retinoic acid signaling sensitizes hepatica stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1. Am. J. Physiol. Gasfroinfesf. Liver Physiol. 293: G809-G816.
43. Reeves HL, Friedman SL. 2002. Activation of hepatic stellate cells - a key issue in liver fibrosis. Front. Biosci. 7: d808-826.
44. Reeves PG, Nielsen FH, Fahey GC Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nufr. 123: 1939-1951.
45. Richter HB, Franke H, Dangel R. 1998. Expression of tenascin, fibronectin and laminin in rat liver fibrogenesis - a comparative immunohisto- chemical study with two models of liver injury. Exp. Toxicol. Pafhol. 50 315-322.
46. Rojind M, Greenwel P. 1994. The matrix of the liver. In The Liver Biology and Pafhology, 3th edn, Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Shafritz D (eds). Raven Press: New York; 843-860.
47. Ross AC, Zolfaghari R. 2004. Regulation of hepatic retinol metabolism: perspectives from studies on vitamin A status. J. Nufr. 134: 269S-275S.
48. Safadi R, Friedman SL. 2002. Hepatic fibrosis. Role of hepatic stellate cell activation. Medscape Gen. Med. 4(3) View article/436461.
49. Sánchez S, Pérez Aguilar R, Genta S, Aybar M, Villecco E, Sanchez Riera A. 2001. Renal extracellular matrix alterations in lead treated rats. J. Appl. Toxicol. 21: 417-423.
50. Schuppan D, Ruehl M, Somasundaram R, Hahn EG. 2001. Matrix as modulator of stellate cell and hepatic fibrogenesis. Semin. Liver Dis. 21: 351-372.
51. Scita G, Wolf G. 1994. Retinoic acid and beta-carotene inhibit fibronectin synthesis and release by fibroblast, antagonism to phorbol ester. Carcinogenesis 15(5): 1043-1048.
52. Senoo H, Hata R. 1994a. Extracellular matrix regulates cell morphology proliferation and tissue formation. Acta Anat. Nippon 69: 719-733.
53. Senoo H, Hata R. 1994b. Cell biology of perisinusoidal stellate cells (vitamin A storing cells) from the viewpoint of retinoid metabolism and function of extracellular matrix. Vitamins 68: 501-513.
54. Tamiguchi M, Takeuchi T, Nakatsuka R, Wanatabe T, Sato T. 2004. Molecular process in acute liver injury and regeneration induced by carbon tetrachloride. Life Sci. 75: 15239-15249.
55. Towbin H. 1979. Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl Acad. Sci. USA 79: 4350-4354.
56. Veness Meehan KA. 1997. Effects of retinol deficiency and hyperocia on collgen gene expression in rat lung. Exp. Lung. Res. 23(6): 569581.
57. Wang L, Potter JJ, Rennie-Tankersley L, Novitskiy, Sipes J, Mezey E. 2007. Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in mice. Biochim. Biophys. Acta 1772: 66-71.
58. Watanabe K, Frangieh G, Reddy CV, Kenyon KR. 1991. Effect of fibronectin on corneal epithelial wound healing in the vitamin A deficient rat. Invest Ophthalmol Visual Sci. 32(7): 2159-2162.
59. Yamada K. 1991. Fibronectin and other cell interactive glycoproteins. In Cell Biology of Extracellular Matrix, 2nd edn, Hay ED (ed.). Plenum Press: New York; 111-139.
60. Zerlauth G, Kim S, Winner J, Kim HY, Bolmer S, Wolf G. 1984. Vitamin A deficiency and serum or plasma fibronectin in the rat and in human subjects. J. Nutr. 114(6): 1169-1172.
61. Zhang XL, Liu JM, Yang CC, Zheng YL, Liu L, Wang ZK, Jiang HQ. 2006. Dynamic expression of extracellular signal regulated kinase in rat liver tissue during hepatic fibrogenesis. World J. Gastroenterol. 12(39): 6376-6381.