Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 6, 2009, Pages 2570-2575

  Kujawska, Małgorzata ^a   Ignatowicz, Ewa ^a   Murias, Marek ^a   Ewertowska, Małgorzata ^a   Mikołajczyk, Katarzyna ^b   Jodynis Liebert, Jadwiga ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

Author keywords

Antioxidant enzymes; Carbon tetrachloride; Comet assay; Lipid peroxidation; N nitrosodiethylamine; Oxidative stress; Protein carbonyls; Rat; Red beetroot

Indexed keywords

CARBON TETRACHLORIDE; DIETHYLNITROSAMINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; XENOBIOTIC AGENT;

ANIMAL; ARTICLE; BEET; BEVERAGE; CHEMISTRY; DIET; DNA DAMAGE; DRUG EFFECT; LIPID PEROXIDATION; LIVER; MALE; OXIDATIVE STRESS; PLANT ROOT; RAT; WISTAR RAT;

ANIMALS; BETA VULGARIS; BEVERAGES; CARBON TETRACHLORIDE; DIET; DIETHYLNITROSAMINE; DNA DAMAGE; LIPID PEROXIDATION; LIVER; MALE; OXIDATIVE STRESS; PLANT ROOTS; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES; XENOBIOTICS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 64549096797     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf803315d     Document Type: Article

References (35)

1. Gonzales, C. A. Nutrition and cancer: the current epidemiological evidence. fir. J. Nutr. 2006, 96, S42-S45.
2. Kanner, J.; Harel, S.; Granit, R. Betalains: a new class of dietary cationized antioxidants. J. Agric. Food Chem. 2001, 49, 5178-5185.
3. Kapadia, G. J.; Azuine, M. A.; Sridhar, R.; Okuda, Y.; Tsuruta, A.; Ichiishi, E.; Mukainake, T.; Takasaki, M.; Konoshima, T.; Nishino, H.; Tokuda, H. Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot. Pharmacol. Res. 2003, 47, 141-148.
4. Kapadia, G. J.; Tokuda, H.; Konoshima, T.; Nishino, H. Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract. Cancer Lett. 1996, 100, 211-214.
5. 4-induced hepatic injury in rats. Fitoterapia 2006, 77, 91-93.
6. Frank, T.; Stintzing, F. K.; Carle, R.; Bitsch, I.; Quaas, G.; Bitsch, R.; Netzel, M. Urinary pharmacokinetics of betalains following consumption of red beet juice in healthy humans. Pharmacol. Res. 2005, 52, 290-297.
7. Tesoriere, L.; Allegra, M.; Butera, D.; Livrea, M. A. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans. Am. J. Clin. Nutr. 2004, 80, 941-945.
8. Sugimura, T. Nutrition and dietary carcinogens. Carcinogenesis 2000, 21, 387-395.
9. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; IARC: Lyon, France, 1987; Vol. 17, Supp. 7.
10. Verna, L.; Whysner, J.: Williams, G. M. N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation. DNA-adduct formation, mutagenicity and tumor initiation. Pharmacol. Ther. 1996, 71, 57-81.
11. Manibusan, M. K.; Odin, M.; Eastmond, D. A. Postulated carbon tetrachloride mode of action: a review. J. Environ. Sci. Health 2007, 25, 185-209.
12. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; IARC: Lyon, France, 1999; Vol. 71.
13. Nilson, T. Studies into the pigments in beet root (Beta vulgaris var rubra L.). Lantbrukshogsk. Ann 1970, 36, 179-219.
14. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biol. Med. 1999, 26, 1231-1237.
15. Sanz, M. J.; Ferrandiz, M. L.; Cejudo, M.; Terencio, M. C.; Gil, B.; Bustos, G.; Ubeda, A.; Gunasegaran, R.; Alcaraz, M. J. Influence of a series of natural flavonoids on free radical generating systems and oxidative stress. Xenobiotica 1994, 24, 689-699.
16. Sedlak, J.; Lindsay, R. H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 1968, 25, 192-205.
17. Jodynis-Liebert, J.; Murias, M.; Błoszyk, E. Effect of sesquiterpene lactones on antioxidant enzymes and some drug-metabolizing enzymes in rat liver and kidney. Planta Med. 2000, 66, 199-205.
18. Mohandas, J.; Marshall, J. J.; Duggin, G. G.; Horvath, J. S.; Tiller, D. J. Low activities of glutathione-related enzymes as factors in the genesis of urinary bladder cancer. Cancer Res. 1984, 44, 5086-5091.
19. Olive, P. L.; Banath, J. P. The comet assay: a method to measure DNA damage in individual cells. Nat. Protoc. 2006, 1, 23-29.
20. Collins, A. R. The comet assay for DNA damage and repair. Mol. Boitechnol. 2004, 26, 249-261.
21. Morton, L. W.; Abu-Amsha Caccetta, R.; Puddey, I. B.; Croft, K. D. Chemistry and biological effects of dietary phenolic compounds: relevance to cardiovascular disease. Clin. Exp. Pharmacol. Physiol. 2000, 27, 152-159.
22. Sheweita, S. A.: El-Gabar, A.; Bastawy, M. Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants. Toxicology 2001, 165, 217-224.
23. Jodynis-Liebert, J.; Matłlawska, I.; Bylka, W.; Murias, M. Antioxidant Activity of Aquilegia vulgaris in CC14-lnduced Liver Injury in Rats. In Recent Progress in Medicinal Plants; Govil, J. N., Singh. V. K., Ahmad, K., Eds.; Stadium Press, LLC: Houston, TX, 2006; Vol. 14 Biopharmaceuticals, pp 59-70.
24. Bansal, A. K.; Bansal, M.; Soni, G.; Bhatnagar, D. Protective role of vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem.-Biol. Interact. 2005, 156, 101-111.
25. Jeena, K. J.; Joy, K. L.; Kuttan, R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett. 1999, 136, 11-16.
26. Summer, K. H.; Klein, D.; Lichtmannegger, J.; Wolff, T. 2-Chloroacetophenone is an effective glutathione depletor in isolated rat hepatocytes. Arch. Toxicol. 1996, 71, 127-129.
27. Rodriguez, C.; Mayo, J. C.; Sainz, R. M.; Antolin, I.; Herrera, F.; Martin, V.; Reiter, R. J. Regulation of antioxidant enzymes: a significant role of melatonin. J. Pineal. Res. 2004, 36, 1-9.
28. Dalle-Donne, I.; Giustarini, D.; Colombo, R.; Rossi, R.; Milzani, A. Protein carbonylation in human diseases. Trends Mol. Med. 2003, 4, 169-176.
29. Bartsch, H.; Nair, H. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch. Surg. 2006, 391, 499-510.
30. Schut, H. A.; Castonguay, A. Metabolism of carcinogenic amino derivatives in various species and DNA alkylation by their metabolites. Drug Metab. Rev. 1984, 15, 753-839.
31. Pegg, A. E. Repair of O(6)-alkylguanine by alkyltransferases. Mutat. Res. 2000, 462, 83-100.
32. Ueno, S.; Aoki, D.; Kubo, F.; Hiwatashi, K.; Matsushita, K.; Oyama, T.; Maruyama, I.; Aikou, T. Roxithromycin inhibits constitutive activation of nuclear factor κB by diminishing oxidative stress in a rat model of hepatocellular carcinoma. Clin. Cancer. Res. 2005, 11, 5645-5650.
33. Winkler, C.; Wirleitner, B.; Schroecksnadel, K.; Schennach, H.; Fuchs, D. In vitro effects of beet root juice on stimulated and unstimulated peripheral blood mononuclear cells. Am. J. Biochem. Biotechnol. 2005, 1, 180-185.
34. 4 poisoning? Free Radical Biol. Med. 2005, 38, 698-710.
35. Halliwell, B. Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept. Nutr. Rev. 1999, 57, 104-113.