2-Chloroacetophenone is an effective glutathione depletor in isolated rat hepatocytes

Archives of Toxicology

Volumn 71, Issue 1-2, 1996, Pages 127-129

  Summer, K H ^a   Klein, D ^b   Lichtmannegger, J ^a   Wolff, T ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

2 Chloroacetophenone; Depletion; Glutathione; Isolated rat hepatocytes

Indexed keywords

GLUTATHIONE; MALEIC ACID DIETHYL ESTER; PHENACYL CHLORIDE; PHORONE; STYRENE OXIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CELLS, CULTURED; GLUTATHIONE; KETONES; LIVER; MALE; MALEATES; OMEGA-CHLOROACETOPHENONE; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0029832583     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Bergmeyer HU (1985) Methods of enzymatic analysis. VCH Verlagsgesellschaft, Weinheim, Germany
2. Berry MN, Friend DS (1969) High yield preparation of isolated rat liver parenchymal cells. A biochemical and fine structural study. J Cell Biol 43: 506-520
3. Boyland E, Chasseaud LF (1970) The effect of some carbonyl compounds on rat liver glutathione levels. Biochem Pharmacol 19: 1526-1528
4. Chakrabarti S, Brodeur J (1981) Metabolism and acute hepatotoxicity of styrene oxide in rats. J Toxicol Environ Health 8: 113-120
5. Dolphin D, Poulson R, Aramovic O (1989) Glutathione. Chemical, biochemical, and medical aspects, Part A. John Wiley & Sons, New York
6. Griffith OW, Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem 254: 7558-7560
7. Högberg J, Kristoferson A (1977) A correlation between glutathione levels and cellular damage in isolated hepatocytes. Eur J Biochem 74: 77-82
8. Khan S, O'Brien PJ (1991) 1-Bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes. Biochem Biophys Res Commun 179: 436-441
9. Larsson A, Orrenius S, Holmgren A, Mannervik B (1983) Functions of glutathione. Biochemical, physiological, texicological, and clinical aspects. Raven Press, New York
10. Maellaro E, Casini AF, Del Bello B, Comporti M (1990) Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents. Biochem Pharmacol 39: 1513-1521
11. Meister A (1988) Glutathione metabolism and its selective modification. J Biol Chem 263: 17205-17208
12. Miccadei S, Kyle ME, Gilfor D, Farber JL (1988) Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes. Arch Biochem Biophys 265: 311-320
13. Nebert DW, Gelboin HV (1968) Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. J Biol Chem 243: 6242-6249
14. Orrenius S, Ormstad K, Thor H, Jewell SA (1983) Turnover and functions of glutathione studied with isolated hepatic and renal cells. Fed Proc 42: 3177-3188
15. Reed DJ. Orrenius S (1977) The role of methionine in glutathione biosynthesis by isolated hepatocytes. Biochem Biophys Res Commun 77: 1257-1264
16. Remoro FJ, Sies H (1984) Subcellular glutathione contents in isolated hepatocytes treated with L-buthionine sulfoximine. Biochem Biophys Res Commun 123: 1116-1121
17. Sies H, Summer KH (1975) Hydroperoxide-metabolizine systems in rat liver. Eur J Biochem 57: 503-512
18. Smith MT, Thor H, Orrenius S (1983) The role of lipid peroxidation in the toxicity of foreign compounds to liver cells. Biochem Pharmacol 32: 763-764
19. Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: application to mammalian blood and other tissues. Anal Biochem 27: 502-522
20. Wolff T (1976) In vitro inhibition of monooxygenase dependent reactions by organic solvents. In: Fours JR, Gut 1 (eds) Industrial and environmental xenobiotics. Excerpta Medica. Amsterdam, pp 196-199
21. Wolff T, Demi E, Wanders H (1979) Aldrin epoxidation, a highly sensitive indicator specific for cytochrome P-450-dependent mono-oxygenase activities. Drug Metab Dispos 7: 301-305
22. Younes M, Sharma SC, Siegers CP (1986) Glutathione depletion by phorone. Organ specificity and effect on hepatic microsomal mixed-function oxidase system. Drug Chem Toxicol 9: 67-73