Crystal structures of constitutive Nitric Oxide synthases in complex with de novo designed inhibitors

Journal of Medicinal Chemistry

Volumn 52, Issue 7, 2009, Pages 2060-2066

  Igarashi, Jotaro ^a,c   Huiying, Li ^a   Jamal, Joumana ^a   Haitao, Ji ^b   Jianguo, Fang ^b   Lawton, Graham R ^b   Silverman, Richard B ^b   Poulos, Thomas L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPYRIDINE; ARGININE; ASPARAGINE; ASPARTIC ACID; GLUTAMIC ACID; GUANIDINE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROGEN BOND; IN VITRO STUDY; PHYSICAL CHEMISTRY;

AMINOPYRIDINES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; ISOENZYMES; MUTATION; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN BINDING; PROTEIN CONFORMATION; PYRROLIDINES; THERMODYNAMICS;

EID: 64549089999     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900007a     Document Type: Article

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