Gap junctions and osteoblast-like cell gene expression in response to fluid flow

Journal of Biomechanical Engineering

Volumn 131, Issue 1, 2009, Pages

  Jekir, Michael G ^a   Donahue, Henry J ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPLIED LOADS; BONE CELLS; BONE FORMATION; BONE-FORMING CELLS; CELL GAPS; CELL RESPONSE; CELL SURFACES; CONTROLLED OSCILLATORY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUID FLOW; GAP JUNCTIONS; IN-VITRO; IN-VIVO; INTERCELLULAR COMMUNICATIONS; MC3T3-E1; MECHANICAL STIMULUS; MRNA LEVEL; OSTEOBLAST-LIKE CELLS; OSTEOBLASTIC CELLS; OSTEOCALCIN; OSTEOGENESIS; OSTEOGENIC RESPONSE; OSTEOPONTIN; SIGNALING PATHWAYS; SIGNALING PROCESS;

BONE; CELL MEMBRANES; CLONING; FLOW OF FLUIDS; GENE EXPRESSION; MONOLAYERS; PROTEINS; SIGNALING;

CLONE CELLS;

GLYCYRRHETINIC ACID; MESSENGER RNA; OSTEOCALCIN; OSTEOPONTIN;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUID FLOW; GAP JUNCTION; GENE EXPRESSION; MECHANICAL STIMULATION; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; SHEAR STRESS; ANIMAL; BONE DEVELOPMENT; CELL JUNCTION; CELL STRAIN 3T3; DRUG EFFECT; GENE EXPRESSION REGULATION; MECHANOTRANSDUCTION; METHODOLOGY; MICROFLUIDICS; PHYSIOLOGY; STIMULATION;

ANIMALS; BALB 3T3 CELLS; GAP JUNCTIONS; GENE EXPRESSION REGULATION; MECHANOTRANSDUCTION, CELLULAR; MICE; MICROFLUIDICS; OSTEOBLASTS; OSTEOGENESIS; PHYSICAL STIMULATION;

EID: 64549086819     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.3005201     Document Type: Article

References (47)

1. Burr, D. B., Robling, A. G., and Turner, C. H., 2002, "Effects of Biomechanical Stress on Bones in Animals," Bone (N.Y.), 30(5), pp. 781-786.
2. Murray, D. W., and Rushton, N., 1990, "The Effect of Strain on Bone Cell Prostaglandin E2 Release: A New Experimental Method," Calcif. Tissue Int., 47(1), pp. 35-39. (Pubitemid 20195422)
3. Pollack, S. R., Salzstein, R., and Pienkowski, D., 1984, "The Electric Double Layer in Bone and Its Influence on Stress-Generated Potentials." Calcif. Tissue Int., 36, pp. S77-S81. (Pubitemid 14043319)
4. Reich, K. M., Gay, C. V., and Frangos, J. A., 1990, "Fluid Shear Stress as a Mediator of Osteoblast Cyclic Adenosine Monophosphate Production," J. Cell Physiol., 143(1), pp. 100-104.
5. Owan, I., Burr, D. B., Turner, C. H., Qiu, J., Tu, Y., Onyia, J. E., and Duncan, R. L., 1997, "Mechanotransduction in Bone: Osteoblasts are More Responsive to Fluid Forces Than Mechanical Strain," Am. J. Physiol., 273, pp. C810-C815.
6. Smalt, R., Mitchell, F. T., Howard, R. L., and Chambers, T. J., 1997, "Induction of NO and Prostaglandin E2 in Osteoblasts by Wall-Shear Stress but not Mechanical Strain," Am. J. Physiol., 273, pp. E751-E758.
7. You, J., Yellowley, C. E., Donahue, H. J., Zhang, Y., Chen, Q., and Jacobs, C. R., 2000, "Substrate Deformation Levels Associated With Routine Physical Activity are Less Stimulatory to Bone Cells Relative to Loading-Induced Oscillatory Fluid Flow," ASME J. Biomech. Eng., 122(4), pp. 387-393.
8. Hung, C. T., Allen, F. D., Pollack, S. R., and Brighton, C. T., 1996, "What is the Role of the Convective Current Density in the Real-Time Calcium Response of Cultured Bone Cells to Fluid Flow?," J. Biomech., 29(11) pp. 1403-1409.
9. You, J., Reilly, G. C., Zhen, X., Yellowley, C. E., Chen, Q., Donahue, H. J., and Jacobs, C. R., 2001, "Osteopontin Gene Regulation by Oscillatory Fluid Flow Via Intracellular Calcium Mobilization and Activation of Mitogen-Activated Protein Kinase in MC3T3-E1 Osteoblasts," J. Biol. Chem., 20(16), pp. 13365-13371.
10. Sudo, H., Kodama, H. A., Amagai, Y., Yamamoto, S., and Kasai, S., 1983, "In Vitro Differentiation and Calcification in a New Clonal Osteogenic Cell Line Derived From Newborn Mouse Calvaria," J. Cell Biol., 96(1), pp. 191-198. (Pubitemid 13155577)
11. Quarles, L. D., Yohay, D. A., Lever, L. W., Caton, R., and Wenstrup, R. J., 1992, "Distinct Proliferative and Differentiated Stages of Murine MC3T3-E1 Cells in Culture: An In Vitro Model of Osteoblast Development," J. Bone Miner. Res., 7(6), pp. 683-692.
12. Choi, J. Y., Lee, B. H., Song, K. B., Park, R. W., Kim, I. S., Sohn, K. Y., Jo, J. S., and Ryoo, H. M., 1996, "Expression Patterns of Bone-Related Proteins During Osteoblastic Differentiation in MC3T3-E1 Cells," J. Cell. Biochem., 61(4), pp. 609-618.
13. Wang, D., Christensen, K., Chawla, K., Xiao, G., Krebsbach, P. H., and Franceschi, R. T., 1999, "Isolation and Characterization Of MC3T3-E1 Preosteoblast Subclones With Distinct In Vitro and In Vivo Differentiation/ Mineralization Potential," J. Bone Miner. Res., 14(6), pp. 893-903. (Pubitemid 29262883)
14. Weinbaum, S., Cowin, S. C., and Zeng, Y., 1994, "A Model for the Excitation of Osteocytes by Mechanical Loading-Induced Bone Fluid Shear Stresses," J. Biomech., 27(3), pp. 339-360. (Pubitemid 24061729)
15. Doty, S. B., 1981, "Morphological Evidence of Gap Junctions Between Bone Cells," Calcif. Tissue Int., 33(5), pp. 509-512.
16. Donahue, H. J., 2000, "Gap Junctions and Biophysical Regulation of Bone Cell Differentiation," Bone (N.Y.), 26(5), pp. 417-422.
17. Li, Z., Zhou, Z., Yellowley, C. E., and Donahue, H. J., 1999, "Inhibiting Gap Junctional Intercellular Communication Alters Expression of Differentiation Markers in Osteoblastic Cells," Bone (N.Y.), 25(6), pp. 661-666. (Pubitemid 29525431)
18. Lecanda, F., Towler, D. A., Ziambaras, K., Cheng, S. L., Koval, M., Steinberg, T. H., and Civitelli, R., 1998, "Gap Junctional Communication Modulates Gene Expression in Osteoblastic Cells," Mol. Biol. Cell, 9(8), pp. 2249-2258.
19. Schiller, P. C., D'Ippolito, G., Balkan, W., Roos, B. A., and Howard, G. A., 2001, "Gap-Junctional Communication Is Required for the Maturation Process of Osteoblastic Cells in Culture," Bone (N.Y.), 28(4), pp. 362-369. (Pubitemid 32385407)
20. Vander Molen, M. A., Rubin, C. T., Mcleod, K. J., Mccauley, L. K., and Donahue, H. J., 1996, "Gap Junctional Intercellular Communication Contributes to Hormonal Responsiveness in Osteoblastic Networks," J. Biol. Chem., 271(21), pp. 12165-12171.
21. Saunders, M. M., You, J., Trosko, J. E., Yamasaki, H., Li, Z., Donahue, H. J., and Jacobs, C. R., 2001, "Gap Junctions and Fluid Flow Response in MC3T3-E1 Cells," Am. J. Physiol.: Cell Physiol., 281(6), pp. C1917-C1925.
22. Saunders, M. M., You, J., Zhou, Z., Li, Z., Yellowley, C. E., Kunze, E. L., Jacobs, C. R., and Donahue, H. J., 2003, "Fluid Flow-Induced Prostaglandin E2 Response of Osteoblastic ROS17/2.8 Cells is Gap Junction-Mediated and Independent of Cytosolic Calcium," Bone (N.Y.), 32(4), pp. 350-356.
23. Ziambaras, K., Lecanda, F., Steinberg, T. H., and Civitelli, R., 1998, "Cyclic Stretch Enhances Gap Junctional Communication Between Osteoblastic Cells," J. Bone Miner. Res., 13(2), pp. 218-228.
24. Davidson, J. S., Baumgarten, I. M., and Harley, E. H., 1986, "Reversible Inhibition of Intercellular Junctional Communication by Glycyrrhetinic Acid," Biochem. Biophys. Res. Commun., 134(1), pp. 29-36.
25. Jacobs, C. R., Yellowley, C. E., Davisa, B. R., Zhou, Z., Cimbala, J. M., and Donahue, H. J., 1998, "Differential Effect of Steady Versus Oscillating Flow on Bone Cells," J. Biomech., 31(11), pp. 969-976. (Pubitemid 28561790)
26. Thi, M. M., Kojima, T., Cowin, S. C., Weinbaum, S., and Spray, D. C., 2003, "Fluid Shear Stress Remodels Expression and Function of Junctional Proteins in Cultured Bone Cells," Am. J. Physiol.: Cell Physiol., 284(2), pp. C389-C403. (Pubitemid 36120077)
27. Cheng, B., Zhao, S., Luo, J., Sprague, E., Bonewald, L. F., and Jiang, J. X., 2001, "Expression of Functional Gap Junctions and Regulation by Fluid Flow in Osteocyte-Like MLO-Y4 Cells," J. Bone Miner. Res., 16(2), pp. 249-259. (Pubitemid 32105406)
28. Li, Y. J., Batra, N. N., You, L., Meier, S. C., Coe, I. A., Yellowley, C. E., and Jacobs, C. R., 2004, "Oscillatory Fluid Flow Affects Human Marrow Stromal Cell Proliferation and Differentiation," J. Orthop. Res., 22(6), pp. 1283-1289. (Pubitemid 39317920)
29. Hillsley, M. V., and Frangos, J. A., 1997, "Alkaline Phosphatase in Osteoblasts Is Down-Regulated by Pulsatile Fluid Flow," Calcif. Tissue Int., 60(1), pp. 48-53.
30. Ducy, P., 2000, "Cbfa-1: A Molecular Switch in Osteoblast Biology," Dev. Dyn., 219(4), pp. 461-471.
31. Kubota, T., Yamauchi, M., Onozaki, J., Sato, S., Suzuki, Y., and Sodek, J., 1993, "Influence of an Intermittent Compressive Force on Matrix Protein Expression by ROS17/2.8 Cells, With Selective Stimulation of Osteopontin," Arch. Oral Biol., 38(1) pp. 23-30.
32. Klein-Nulend, J., Roelofsen, J., Semeins, C. M., Bronckers, A. L., and Burger, E. H., 1997, "Mechanical Stimulation of Osteopontin mRNA Expression and Synthesis in Bone Cell Cultures," J. Cell Physiol., 170(2), pp. 174-181. (Pubitemid 27076218)
33. Toma, C. D., Ashkar, S., Gray, M. L., Schaffer, J. L., and Gerstenfeld, L. C., 1997, "Signal Transduction Of Mechanical Stimuli Is Dependent on Microfilament Integrity: Identification of Osteopontin as a Mechanically Induced Gene in Osteoblasts," J. Bone Miner. Res., 12(10), pp. 1626-1636. (Pubitemid 27422363)
34. Harter, L. V., Hruska, K. A., and Duncan, R. L., 1995, "Human Osteoblast-Like Cells Respond to Mechanical Strain With Increased Bone Matrix Protein Production Independent of Hormonal Regulation," Endocrinology, 136(2), pp. 528-535.
35. Miles, R. R., Turner, C. H., Santerre, R., Tu, Y., Mcclelland, P., Argot, J., Dehoff, B. S., Mundy, C. W., Rosteck, P. R., Jr., Bidwell, J., Sluka, J. P., Hock, J., and Onyia, J. E., 1998, "Analysis of Differential Gene Expression in Rat Tibia After an Osteogenic Stimulus In Vivo: Mechanical Loading Regulates Osteopontin and Myeloperoxidase," J. Cell. Biochem., 68(3), pp. 355-365.
36. Terai, K., Takano-Yamamoto, T., Ohba, Y., Hiura, K., Sugimoto, M., Sato, M., Kawahata, H., Inaguma, N., Kitamura, Y., and Nomura, S., 1999, "Role of Osteopontin in Bone Remodeling Caused by Mechanical Stress," J. Bone Miner. Res., 14(6), pp. 839-849. (Pubitemid 29262877)
37. Morinobu, M., Ishijima, M., Rittling, S. R., Tsuji, K., Yamamoto, H., Nifuji, A., Denhardt, D. T., and Noda, M., 2003, "Osteopontin Expression in Osteoblasts and Osteocytes During Bone Formation Under Mechanical Stress in the Calvarial Suture In Vivo," J. Bone Miner. Res., 18(9), pp. 1706-1715. (Pubitemid 37022930)
38. Zhang, R., Supowit, S. C., Klein, G. L., Lu, Z., Christensen, M. D., Lozano, R., and Simmons, D. J., 1995, "Rat Tail Suspension Reduces Messenger RNA Level for Growth Factors and Osteopontin and Decreases the Osteoblastic Differentiation of Bone Marrow Stromal Cells," J. Bone Miner. Res., 10(3), pp. 415-423.
39. Civitelli, R., Beyer, E. C., Warlow, P. M., Robertson, A. J., Geist, S. T., and Steinberg, T. H., 1993, "Connexin43 Mediates Direct Intercellular Communication in Human Osteoblastic Cell Networks," J. Clin. Invest., 91(5), pp. 1888-1896. (Pubitemid 23141456)
40. Cherian, P. P., Cheng, B., Gu, S., Sprague, E., Bonewald, L. F., and Jiang, J. X., 2003, "Effects of Mechanical Strain on the Function of Gap Junctions in Osteocytes are Mediated Through the Prostaglandin EP2 Receptor," J. Biol. Chem., 278(44), pp. 43146-43156. (Pubitemid 37345933)
41. Reich, K. M., Gay, C. V., and Frangos, J. A., 1990, "Fluid Shear Stress as a Mediator of Osteoblast Cyclic Adenosine Monophosphate Production," J. Cell Physiol., 143(1), pp. 100-104.
42. Kondo, H., Guo, J., and Bringhurst, F. R., 2002, "Cyclic Adenosine Monophosphate/Protein Kinase a Mediates Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor Regulation of Osteoclastogenesis and Expression of RANKL and Osteoprotegerin mRNAs by Marrow Stromal Cells," J. Bone Miner. Res., 17(9), pp. 1667-1679.
43. Jagodzinski, M., Drescher, M., Zeichen, J., Hankemeier, S., Krettek, C., Bosch, U., and Van Griensven, M., 2004, "Effects of Cyclic Longitudinal Mechanical Strain and Dexamethasone on Osteogenic Differentiation of Human Bone Marrow Stromal Cells," Eur. Cells Mater, 16(7), pp. 35-41. (Pubitemid 39347334)
44. Chen, Y. J., Wang, C. J., Yang, K. D., Chang, P. R., Huang, H. C., Huang, Y. T., Sun, Y. C., and Wang, F. S., 2003, "Pertussis Toxin-Sensitive Galphai Protein and ERK-Dependent Pathways Mediate Ultrasound Promotion of Osteogenic Transcription in Human Osteoblasts," FEBS Lett., 554(2), pp. 154-158.
45. Naruse, K., Miyauchi, A., Itoman, M., and Mikuni-Takagaki, Y., 2003, "Distinct Anabolic Response of Osteoblast to Low-Intensity Pulsed Ultrasound," J. Bone Miner. Res., 18(2), pp. 360-369. (Pubitemid 36125929)
46. Tanaka, S. M., Li, J., Duncan, R. L., Yokota, H., Burr, D. B., and Turner, C. H., 2003, "Effects of Broad Frequency Vibration on Cultured Osteoblasts," J. Biomech., 36(1), pp. 73-80. (Pubitemid 35448095)
47. Ohta, T., Azuma, Y., Kiyoki, M., Eguchi, H., Arita, M., Hosoda, K., Tsukamoto, Y., Nakamura, T., 1996, "Measurement of Intact Rat Osteocalcin in Osteoblast (ROS17/2.8) Cells and in Ovariectomized Rats with a Sandwich Enzyme Immunoassay," Calcif. Tissue Int., 59(4), pp. 283-290. (Pubitemid 26353024)