Rpd3p relocation mediates a transcriptional response to rapamycin in yeast

Chemistry and Biology

Volumn 11, Issue 3, 2004, Pages 295-299

  Humphrey, Emily L ^a   Shamji, Alykhan F ^a   Bernstein, Bradley E ^a,b   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; RAPAMYCIN; REPRESSOR PROTEIN; RPD3 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; DOWN REGULATION; DRUG EFFECT; FUNGAL GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PROMOTER REGION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

DOWN-REGULATION; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HISTONE DEACETYLASES; PROMOTER REGIONS (GENETICS); PROTEIN TRANSPORT; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 6444241134     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2004.03.001     Document Type: Article

References (26)

1. Hardwick J.S., Kuruvilla F.G., Tong J.K., Shamji A.F., Schreiber S.L. Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the TOR proteins. Proc. Natl. Acad. Sci. USA. 96:1999;14866-14870.
2. Cardenas M.E., Cutler N.S., Lorenz M.C., Di Como C.J., Heitman J. The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 13:1999;3271-3279.
3. Rohde J.R., Cardenas M.E. The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. Mol. Cell. Biol. 23:2003;629-635.
4. Kurdistani S.K., Robyr D., Tavazoie S., Grunstein M. Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat. Genet. 31:2002;248-254.
5. Rando O.J., Chi T.H., Crabtree G.R. Second messenger control of chromatin remodeling. Nat. Struct. Biol. 10:2003;81-83.
6. Tsang C.K., Bertram P.G., Ai W., Drenan R., Zheng X.F. Chromatin-mediated regulation of nucleolar structure and RNA Pol I localization by TOR. EMBO J. 22:2003;6045-6056.
7. Cutler N.S., Pan X., Heitman J., Cardenas M.E. The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Mol. Biol. Cell. 12:2001;4103-4113.
8. Schmelzle T., Hall M.N. TOR, a central controller of cell growth. Cell. 103:2000;253-262.
9. Shamji A.F., Kuruvilla F.G., Schreiber S.L. Partitioning the transcriptional program induced by rapamycin among the effectors of the TOR proteins. Curr. Biol. 10:2000;1574-1581.
10. Beck T., Hall M.N. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature. 402:1999;689-692.
11. Saxena D., Kannan K.B., Brandriss M.C. Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae. Eukaryot. Cell. 2:2003;552-559.
12. Komeili A., Wedaman K.P., O'Shea E.K., Powers T. Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J. Cell Biol. 151:2000;863-878.
13. Powers T., Walter P. Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol. Biol. Cell. 10:1999;987-1000.
14. Duvel K., Santhanam A., Garrett S., Schneper L., Broach J.R. Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. Mol. Cell. 11:2003;1467-1478.
15. Robyr D., Suka Y., Xenarios I., Kurdistani S.K., Wang A., Suka N., Grunstein M. Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell. 109:2002;437-446.
16. Kurdistani S.K., Grunstein M. Histone acetylation and deacetylation in yeast. Nat. Rev. Mol. Cell Biol. 4:2003;276-284.
17. Kadosh D., Struhl K. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell. 89:1997;365-371.
18. Goldmark J.P., Fazzio T.G., Estep P.W., Church G.M., Tsukiyama T. The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell. 103:2000;423-433.
19. Cioci F., Vu L., Eliason K., Oakes M., Siddiqi I.N., Nomura M. Silencing in yeast rDNA chromatin. reciprocal relationship in gene expression between RNA polymerase I and II Mol. Cell. 12:2003;135-145.
20. Bernstein B.E., Tong J.K., Schreiber S.L. Genomewide studies of histone deacetylase function in yeast. Proc. Natl. Acad. Sci. USA. 97:2000;13708-13713.
21. Rundlett S.E., Carmen A.A., Suka N., Turner B.M., Grunstein M. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature. 392:1998;831-835.
22. Reid J.L., Iyer V.R., Brown P.O., Struhl K. Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol. Cell. 6:2000;1297-1307.
23. Bernstein B.E., Humphrey E.L., Erlich R.L., Schneider R., Bouman P., Liu J.S., Kouzarides T., Schreiber S.L. Methylation of histone H3 Lys 4 in coding regions of active genes. Proc. Natl. Acad. Sci. USA. 99:2002;8695-8700.
24. Liu C.L., Schreiber S.L., Bernstein B.E. Development and validation of a T7 based linear amplification for genomic DNA. BMC Genomics. 4:2003;19.
25. Carroll A.S., Bishop A.C., DeRisi J.L., Shokat K.M., O'Shea E.K. Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response. Proc. Natl. Acad. Sci. USA. 98:2001;12578-12583.
26. Eisen M.B., Spellman P.T., Brown P.O., Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA. 95:1998;14863-14868.