Interaction between the Purα and E2F-1 transcription factors

Anticancer Research

Volumn 24, Issue 5 A, 2004, Pages 2585-2594

  Darbinian, Nune ^a   White, Martyn K ^a   Gallia, Gary L ^b   Amini, Shohreh ^a   Rappaport, Jay ^a   Khalili, Kamel ^a  

^a Temple University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; E2F1; Growth inhibition; Pur ; RNA association

Indexed keywords

RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR PURALPHA; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIHYDROFOLATE REDUCTASE; DNA BINDING PROTEIN; E2F1 PROTEIN, HUMAN; PURA PROTEIN, HUMAN; TRANSCRIPTION FACTOR E2F;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLONY FORMATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; BINDING SITE; BIOSYNTHESIS; CELL GROWTH; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; GLIOBLASTOMA; MEDULLOBLASTOMA; METABOLISM; MUTAGENESIS; PATHOLOGY; PHYSIOLOGY; RNA PROBE; TRANSACTIVATION; TUMOR CELL LINE;

BINDING SITES; CELL CYCLE PROTEINS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; GLIOBLASTOMA; HUMANS; MEDULLOBLASTOMA; MUTAGENESIS; PROMOTER REGIONS (GENETICS); RNA PROBES; TETRAHYDROFOLATE DEHYDROGENASE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 6444239947     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. La Thangue NB: DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem Sci 19: 108-114, 1994.
2. Shan B, Zhu X, Chen P, Durfee T, Yang Y, Sharp D and Lee W: Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol Cell Biol 12: 5620-5631, 1992.
3. Weinberg RA: The retinoblastoma protein and cell cycle control. Cell 81: 323-330, 1995.
4. Weinberg RA: E2F and cell proliferation: a world turned upside down. Cell 55: 457-459, 1996.
5. Young AP, Nagarajan R and Longmore GD: Mechanisms of transcriptional regulation by Rb-E2F segregate by biological pathway. Oncogene 22: 7209-7217, 2003.
6. Bates S, Phillips AC, Clark PA, Stott F, Peters G, Ludwig RL and Vousden KH: pWARF links the tumour suppressors RB and p53. Nature 595: 124-125, 1998.
7. Vogelstein B, Lane D and Levine AJ: Surfing the p53 network. Nature 408: 307-310, 2000.
8. Melillo RM, Helin K, Lowy DR and Schiller JT: Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins. Mol Cell Biol 14: 8241-8249, 1994.
9. Wu X and Levine AJ: p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 91: 3602-3606, 1994.
10. DeCaprio JA, Ludlow JW, Figge J, Shew JY, Huang CM, Lee WH, Marsilio E, Paucha E and Livingston DM: SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 54: 275-283, 1988.
11. Hallstrom TC and Kevins JR: Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci USA 100: 10848-10853, 2003.
12. Ishizaki J, Kevins JR and Sullenger BA: Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. Nat Med 2: 1386-1389, 1996.
13. Haas S, Gordon J and Khalili K: A developmentally regulated DNA-binding protein from mouse brain stimulates myelin basic protein gene expression. Mol Cell Biol 13: 3103-3112, 1993.
14. Haas S, Thatikunta P, Steplewski A, Johnson EM, Khalili K and Amini S: A 39-kD DNA-binding protein from mouse brain stimulates transcription of myelin basic protein gene in oligodendrocytic cells. J Cell Biol 130: 1171-1179, 1995.
15. Bergemann AD and Johnson EM: The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication. Mol Cell Biol 12: 1257-1265, 1992.
16. Bergemann AD, Ma ZW and Johnson EM: Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein. Mol Cell Biol 12: 5673-5682, 1992.
17. Ma ZW, Bergemann AD and Johnson EM: Conservation in human and mouse Purα of a motif common to several proteins involved in initiation of DNA replication. Gene 149: 311-314, 1994.
18. Liu H and Johnson EM: Distinct proteins encoded by alternative transcripts of the PURγ gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation. Nucleic Acids Res 30: 2417-2426, 2002.
19. Johnson EM: The Pur protein family: clues to function from recent studies on cancer and AIDS. Anticancer Res 23: 2093-2100, 2003.
20. Gallia GL, Johnson EM and Khalili K: Purα: a multifunctional single-stranded DNA- and RNA-binding protein. Nucleic Acids Res 28: 3197-3205, 2000.
21. Darbinian N, Gallia GL and Khalili K: Helix-destabilizing properties of the human single-stranded DNA- and RNA-binding protein Purα. J Cell Biochem 80: 589-595, 2001.
22. Johnson EM, Chen PL, Krachmarov CP, Barr SM, Kanovsky M and Ma ZW: Association of human Purα with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Purα recognition element. J Biol Chem 270: 24352-24360, 1995.
23. Darbinian N, Gallia GL, Kundu M, Shcherbik N, Tretiakova A, Giordano A and Khalili K: Association of Purα and E2F-1 suppresses transcriptional activity of E2F-1. Oncogene 18: 6398-6402, 1999.
24. Tretiakova A, Steplewski A, Johnson EM, Khalili K and Amini S: Regulation of myelin basic protein gene transcription by Sp1 and Purα: evidence for association of Sp1 and Purα in brain. J Cell Physiol 181: 160-168, 1999.
25. Safak M, Gallia GL and Khalili K: Reciprocal interaction between two cellular proteins, Purα and YB-1, modulates transcriptional activity of JCVCY in glial cells. Mol Cell Biol 19: 2712-2723, 1999.
26. Gallia GL, Darbinian N, Tretiakova A, Ansari SA, Rappaport J, Brady J, Wortman MJ, Johnson EM and Khalili K: Association of HIV-1 Tat with the cellular protein, Purα, is mediated by RNA. Proc Natl Acad Sci USA 96: 11572-11577, 1999.
27. Gallia GL, Safak M and Khalili K: Interaction of the single-stranded DNA-binding protein Purα with the human polyomavirus JC virus early protein T-antigen. J Biol Chem 273: 32662-32669, 1998.
28. Itoh H, Wortman MJ, Kanovsky M, Uson RR, Gordon RE, Alfano N and Johnson EM: Alterations in Pura levels and intracellular localization in the CV-1 cell cycle. Cell Growth Differ 9: 651-665, 1998.
29. Stacey DW, Hitomi M, Kanovsky M, Gan L and Johnson EM: Cell cycle arrest and morphological alterations following microinjection of NIH3T3 cells with Purα. Oncogene 18: 4254-4261, 1999.
30. Barr SM and Johnson EM: Ras-induced colony formation and anchorage-independent growth inhibited by elevated expression of Purα in NIH3T3 cells. J Cell Biochem 81: 621-638, 2001.
31. Darbinian N, Gallia GL, King J, Del Valle L, Johnson EM and Khalili K: Growth inhibition of glioblastoma cells by human Purα. J Cell Physiol 189: 334-340, 2001.
32. Bruchova H, Borovanova T, Klamova H and Brdicka R: Gene expression profiling in chronic myeloid leukemia patients treated with hydroxyurea. Leuk Lymphoma 43: 1289-1295, 2002.
33. Lezon-Geyda K, Najfeld V and Johnson EM: Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia. Leukemia 15: 954-962, 2001.
34. Kundu M, Guermah M, Roeder RG, Amini S and Khalili K: Interaction between cell cycle regulator, E2F-1, and NF-kappaB mediates repression of HIV-1 gene transcription. J Biol Chem 272: 29468-29474, 1997.
35. Mudryj M, Hiebert SW and Nevins JR: A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway. EMBO J 9: 2179-2184, 1990.
36. Tretiakova A, Gallia GL, Shcherbik N, Jameson B, Johnson EM, Amini S and Khalili K: Association of Purα with RNAs homologous to 7 SL determines its binding ability to the myelin basic protein promoter DNA sequence. J Biol Chem 273: 22241-22247, 1998.
37. Graham FL and van der Eb AJ: A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52: 456-467, 1973.
38. Khalili K, Del Valle L, Muralidharan V, Gault WJ, Darbinian N, Otte J, Meier E, Johnson EM, Daniel DC, Kinoshita Y, Amini S and Gordon J: Purα is essential for postnatal brain development and developmentally coupled cellular proliferation as revealed by genetic inactivation in the mouse. Mol Cell Biol 23: 6857-6875, 2003.