Increased skin carcinogenesis in a keratinocyte directed thioredoxin-1 transgenic mouse

Carcinogenesis

Volumn 25, Issue 10, 2004, Pages 1983-1989

  Mustacich, Debbie ^a   Wagner, Amary ^a   Williams, Ryan ^a   Bair, Warner ^a   Barbercheck, Loretta ^a   Stratton, Steven P ^a   Bhattacharyya, Achyut K ^b   Powis, Garth ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHORBOL 13 ACETATE 12 MYRISTATE; THIOREDOXIN; TUMOR PROMOTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SIZE; CANCER STAGING; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CANCER; SKIN CARCINOGENESIS; SKIN PAPILLOMA; TOXICITY TESTING; TRANSGENIC MOUSE; TUMOR PROMOTION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; FEMALE; HUMANS; KERATINOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PAPILLOMA; PROMOTER REGIONS (GENETICS); SKIN; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; THIOREDOXIN; ULTRAVIOLET RAYS;

EID: 6444234763     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh195     Document Type: Article

References (49)

1. Powis,G. and Montfort,WR. (2001) Properties and biological activities of thioredoxins. Ann. Rev. Pharmacol. Toxicol., 41 261-295.
2. Arner,E.S. and Holmgren,A. (2000) Physiological functions of thioredoxin and thioredoxin reductase. Eur. J. Biochem., 267, 6102-6109.
3. Hirota,K., Nakamura,H., Masutani,H. and Yodoi,J. (2002) Thioredoxin superfamily and thioredoxin-inducing agents. Ann. N. Y. Acad. Sci. USA, 957, 199.
4. Watson,W.H., Chen,Y. and Jones,D.P. (2003) Redox state of glutathione and thioredoxin in differentiation and apoptosis. BioFactors, 17, 307-314.
5. Mustacich,D. and Powis,G. (2000) Thioredoxin reductase. Biochem. J., 346, 1-8.
6. Matthews,J.R., Wakasugi,N., Virelizier,J.-L., Yodoi,J. and Hay,R.T. (1992) Thioredoxin regulates the DNA binding activity of NF-kappaB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res., 20, 3821-3830.
7. Gasdaska,P.Y., Oblong,J.E., Cotgreave,I.A. and Powis,G. (1994) The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors. Biochim. Biophys. Acta, 1218, 292-296.
8. Grippo,J.F., Tienrungroj,W., Dahmer,M.K., Housley,P.R. and Pratt,W.B. (1983) Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin. J. Biol. Chem., 258 13658-13664.
9. Hirota,K., Matsui,M., Iwata,S., Nishiyama,A., Mori,K. and Yodoi,J. (1997) AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc. Natl Acad. Sci. USA 94, 3633-3638.
10. Ueno,M., Masutani,H., Jun Arai,R., Yamauchi,A., Hirota,K., Sakai,T., Inamoto,T., Yamaoka,Y., Yodoi,J. and Nikaido,T. (2000) Thioredoxin-dependent redox regulation of p53-mediated p21 activation. J. Biol. Chem., 274, 35809-35815.
11. Welsh,S.J., Bellamy,W.T., Briehl,M.M. and Powis,G. (2002) The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis. Cancer Res., 62, 5089-5095.
12. Abate,C., Patel,L., Rauscher III,F.J. and Curran,T. (1990) Redox regulation of fos and jun DNA-binding activity in vitro. Science 249, 1157-1161.
13. Saitoh,M., Nishitoh,H., Fujii,M., Takeda,K., Tobiume,K., Sawada,Y., Kawabata,M., Miyazono,K. and Ichijo,H. (1998) Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J., 17, 2596-2606.
14. Watson,J.A., Rumsby,M.G. and Wolowacz,R.G. (1999) Phage display identifies thioredoxin and superoxide dismutase as novel protein kinase C-interacting proteins: thioredoxin inhibits protein kinase C-mediated phosphorylation of histone. Biochem. J., 343, 301-305.
15. Meuillet,E., Mahadevan,D., Berggren,M., Coon,A. and Powis,G. (2004) Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity. Arch. Biocem. Biophys., (in press).
16. Chae,H.Z., Kim,H.J., Kang,S.W. and Rhee,S.G. (1999) Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin. Diabetes Res. Clin. Pract. 45, 101-112.
17. Baker,A., Payne,C.M., Briehl,M.M. and Powis,G. (1997) Thioredoxin, a gene found overexpressed in human cancer, inhibitis apoptosis in vitro and in vivo. Cancer Res., 57, 5162-5167.
18. Freemerman,A.J. and Powis,G. (2000) A redox-inactive thioredoxin reduces growth and enhances apoptosis in WEH17.2 cells. Biochem. Biophys. Res. Commun., 274, 136-141.
19. Gallegos,A., Gasdaska,J.R., Taylor,C.W., Paine-Murrieta,G.D., Goodman,D., Gasdaska,P.Y., Berggren,M., Briehl,M.M. and Powis,G. (1996) Transfection with human thioredoxin increases cell proliferation and a dominant negative mutant thioredoxin reverses the transformed phenotype of breast cancer cells. Cancer Res., 56, 5765-5770.
20. Fujii,S., Nanbu,Y., Nonogaki,H., Konishi,I., Mori,T., Masutani,H. and Yodoi,J. (1991) Coexpression of adult T-cell leukemia-derived factor, a human thioredoxin homologue, and human papillomavirus DNA in neoplastic cervical squamous epithelium. Cancer 68, 1583-1591.
21. Soini,Y., Kahlos,K., Napankangas,U., Kaarteenaho-Wiik,R., Saily,M., Koistinen,P., Paaakia,P., Holmgren,A. and Kinnula,V.L. (2001) Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma. Clin. Cancer Res., 7, 1750-1757.
22. Kakolyris,S., Giatromanolaki,A., Koukourakis,M., Powis,G., Souglakos,J., Sivridis,E., Gatter,K.C. and Harris,A.L. (2001) Thioredoxin expression is associated with lymph node status and prognosis in early operable non small cell lung cancer (NSCLC). Clin. Cancer Res., 7, 3087-3091.
23. Kawahara,N., Tanaka,T., Yokomizo,A., Nanri,H., Ono,M., Wada,M., Kohno,K., Takenaka,K., Sugimachi,K. and Kuwano,M. (1996) Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin. Cancer Res., 56, 5330-5333.
24. Nakamura,H., Masutani,H., Tagaya,Y., Yamauchi,A., Inamoto,T., Nanbu,Y., Fujii,S., Ozawa,K. and Yodoi,J. (1992) Expression and growth-promoting effect of adult T-cell leukemia-derived factor. A human thioredoxin homologue in hepatocellular carcinoma. Cancer, 69 2091-2097.
25. Wakita,H., Yodoi,J., Masutani,H., Toda,K. and Takigawa,M. (1992) Immunohistochemical distribution of adult T-cell leukemia-derived factor/thioredoxin in epithelial components of normal and pathologic human skin conditions. J. Invest. Dermatol., 99, 101-107.
26. Grogan,T.M., Fenoglio-Prieser,C., Zeheb,R. et al. (2000) Thioredoxin, a puntative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival. Hum. Pathol., 31, 475-481.
27. Raffel,J., Bhattacharyya,A.K., Gallegos,A., Cui,H., Einspahr,J.G., Alberts,D.S. and Powis,G. (2002) Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival. J. Lab. Clin. Med., 142, 46-51.
28. Sachi,Y., Hirota,K., Masutani,H., Toda,K., Takahashi,O., Takigawa,M. and Yodoi,J. (1995) Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells. Immunol. Lett., 44, 189-193.
29. Funasaka,Y. and Ichihashi,M. (1997) The effect of ultraviolet B induced adult cell leukemia-derived factor/thioredoxin (ADF/TRXD) on survival and growth of human melanocytes. Pigment Cell Res., 10 68-73.
30. Didier,C., Kerblat,I., Drouet,C., Favier,A., Beani,J.C. and Richard,M.J. (2001) Induction of thioredoxin by ultraviolet-A radiation prevents oxidative-mediated cell death in human skin fibroblasts. Free Rad. Biol. Med., 31, 585-598.
31. Didier,C., Pouget,J.P., Cadet,J., Favier,A., Beani,J.C. and Richard,M. (2001) Modulation of exogenous and endogenous levels of thioredoxin in human skin fibroblasts prevents DNA damaging effect of ultraviolet A radiation. Free Rad. Biol. Med., 30, 537-546.
32. Trouba,K.J., Hamadeh,H.K., Amin,R.P. and Germolec,D.R. (2002) Oxidative stress and its role in skin disease. Antiox. Redox Sign., 4, 665-673.
33. Raff,M.C. (1992) Social controls on cell survival and cell death. Nature, 356, 397-400.
34. McGargill,MA., Mayerova,D., Stefanski,HE., Koehn,B., Parke,EA., Jameson,SC., Panoskaltsis-Mortari,A. and Hogquist,KA. (2002) A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter. J Immunol., 169 2141-2147.
35. Kumar,S. and Holmgren,A. (1999) Induction of thioredoxin, thioredoxin reductase and glutaredoxin activity in mouse skin by TPA, a calcium ionophore and other tumor promoters. Carcinogenesis, 20 1761-1767.
36. Hanahan,D. and Weinberg,R.A. (2000) The hallmarks of cancer. Cell, 100, 57-70.
37. DiGiovanni,J., Prichett,W.P., Decina,P.C. and Diamond,L. (1984) DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis, 5, 1493-1498.
38. Naito,M., Chenicek,K.J., Naito,Y. and DiGiovanni,J. (1988) Susceptibility to phorbol ester skin tumor promotion in (C57BL/6 × DBA/2)F1 mice is inherited as an incomplete dominant trait: evidence for multi-locus involvement. Carcinogenesis, 9, 639-645.
39. Slaga,T.J. (1986) SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice. Environ. Health Perspect., 68, 27-32.
40. Takagi,Y., Mitsui,A., Nishiyama,A., Nozaki,K., Sono,H., Gon,Y., Hashimoto,N. and Yodoi,J. (1999) Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage. Proc. Natl Acad. Sci. USA, 96, 4131-4136.
41. Shioji,K., Kishimoto,C., Nakamura,H., Masutani,H., Yuan,Z., Oka,S. and Yodoi,J. (2002) Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity. Circulation, 106, 1403-1409.
42. Yoon,B.I., Hirabayashi,Y., Kaneko,T., Kodama,Y., Kim,D.Y. and Inoue,T. (2001) Transgene expression of thioredoxin (TRX/ADF) protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced hematotoxicity. Arch. Environ. Contamin. Toxi., 41, 232-236.
43. Tanito,M., Masutani,H., Nakamura,H., Oka,S., Ohira,A. and Yodoi,J. (2002) Attenuation of retinal photooxidative damage in thioredoxin transgenic mice. Neurosci. Lett., 326, 142-146.
44. Nakamura,H., Tamura,S., Watanabe,I., Iwasaki,T. and Yodoi,J. (2002) Enhanced resistancy of thioredoxin-transgenic mice against influenza virus-induced pneumonia. Immunol. Lett., 82, 165-170.
45. Murata,Y., Amao,M., Yoneda,J. and Hamuro,J. (2002) Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging. Mol. Immunol., 38 747-757.
46. Hotta,M., Tashiro,F., Ikegami,H., Niwa,H., Ogihara,T., Yodoi,J. and Miyazaki,J. (1998) Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J. Exp. Med., 188, 1445-1451.
47. Lu,Y.P., Lou,Y.R., Yen,P., Newmark,H.L., Mirochnitchenko,O.I., Inouye,M. and Huang,MT. (1997) Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase. Cancer Res., 57, 1468-1474.
48. Crack,P.J., Taylor,J.M., Flentjar,N.J., de Haan,J., Hertzog,P., Iannello,R.C. and Kola,I. (2001) Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J. Neurochem. 78, 1389-1399.
49. Lee,M., Hyun,D.H., Halliwel],B. and Jenner,P. (2001) Effect of over-expression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4-hydroxynonenal or serum deprivation: potentiation of injury by ALS-related mutant superoxide dismutases and protection by Bcl-2. J. Neurochem., 78, 209-220.